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Recruiting Phase 3 Interventional

A Study of Metastases Free Survival With Saruparib vs Placebo Added to a Standard RT/ADT in Men With High-risk Prostate Cancer With a BRCA Mutation

ClinicalTrials.gov ID: NCT06952803

Public ClinicalTrials.gov record NCT06952803. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 2, 2026, 12:52 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomised, Double-blind, Placebo-controlled, Phase III Study of Adjuvant Saruparib (AZD5305) in Patients With BRCAm Localised High-Risk Prostate Cancer Receiving Radiotherapy With Androgen Deprivation Therapy (EvoPAR-Prostate02).

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of the study is to demonstrate superiority of Saruparib (AZD5305) relative to placebo added to a standard radiation therapy (RT) + androgen deprivation therapy (ADT) regimen by assessment of metastases-free survival in participants with high-risk and very high-risk localised/locally advanced prostate cancer with a breast cancer gene mutation (BRCAm).

Study identification

NCT ID
NCT06952803
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
700 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
Male
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Aug 5, 2025
Primary completion
Mar 30, 2033
Completion
Apr 29, 2036
Last update posted
Aug 20, 2026

2025 – 2036

United States locations

U.S. sites
45
U.S. states
22
U.S. cities
43
Facility City State ZIP Site status
Research Site Phoenix Arizona 85054 Recruiting
Research Site Tucson Arizona 85741 Withdrawn
Research Site La Jolla California 92037 Recruiting
Research Site La Jolla California 92093 Recruiting
Research Site Los Angeles California 90048 Recruiting
Research Site San Diego California 92123 Recruiting
Research Site San Luis Obispo California 93401 Recruiting
Research Site Lakewood Colorado 80215 Recruiting
Research Site Hialeah Florida 33016 Recruiting
Research Site Jacksonville Florida 32224 Recruiting
Research Site Tallahassee Florida 32308 Withdrawn
Research Site Tampa Florida 33612 Recruiting
Research Site Newnan Georgia 30265 Recruiting
Research Site Chicago Illinois 60611 Recruiting
Research Site Chicago Ridge Illinois 60415 Recruiting
Research Site Lake Barrington Illinois 60010 Withdrawn
Research Site Greenwood Indiana 46143 Recruiting
Research Site Jeffersonville Indiana 47130 Withdrawn
Research Site Bethesda Maryland 20817 Withdrawn
Research Site Towson Maryland 21204 Recruiting
Research Site Plymouth Massachusetts 02360 Recruiting
Research Site Rochester Minnesota 55905 Recruiting
Research Site Hackensack New Jersey 07601 Recruiting
Research Site Voorhees Township New Jersey 08043 Recruiting
Research Site Albany New York 12206 Withdrawn
Research Site New York New York 10065 Recruiting
Research Site Syracuse New York 13210 Recruiting
Research Site Columbus Ohio 43230 Recruiting
Research Site Springfield Oregon 97477 Recruiting
Research Site Hershey Pennsylvania 17033 Recruiting
Research Site Lancaster Pennsylvania 17601 Recruiting
Research Site Pittsburgh Pennsylvania 15212 Recruiting
Research Site Providence Rhode Island 02903 Recruiting
Research Site Myrtle Beach South Carolina 29572 Recruiting
Research Site Nashville Tennessee 37209 Recruiting
Research Site Austin Texas 78705 Recruiting
Research Site Austin Texas 78745 Recruiting
Research Site Houston Texas 77074 Recruiting
Research Site San Antonio Texas 78229 Recruiting
Research Site Spring Texas 77380 Recruiting
Research Site Salt Lake City Utah 84112 Withdrawn
Research Site Norfolk Virginia 23502 Recruiting
Research Site Roanoke Virginia 24014 Recruiting
Research Site Virginia Beach Virginia 23462 Recruiting
Research Site Seattle Washington 98109 Withdrawn

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 301 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06952803, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Aug 20, 2026 · Synced Sep 2, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT06952803 live on ClinicalTrials.gov.

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