Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardioverter Defibrillator
Public ClinicalTrials.gov record NCT06964464. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This prospective, multicenter, open-label, randomized comparative effectiveness trial, titled CARVTOP-ICD, evaluates the impact of carvedilol versus metoprolol succinate in patients with heart failure with reduced ejection fraction (HFrEF) and an implantable cardioverter defibrillator (ICD). The study will enroll 2,000 participants across 100 U.S. sites and includes an 18-month feasibility phase with 100 participants from 15 sites. Eligible participants must be currently treated with metoprolol succinate and willing to switch to carvedilol, with randomization in a 1:1 ratio. Participants will be followed for up to 3 years, with regular assessments including ICD interrogations, medication adherence, healthcare utilization, and quality of life surveys. The primary endpoint is the first occurrence of any ICD therapy (appropriate or inappropriate), cardiovascular (CV) hospitalization, or CV death. Secondary endpoints include ICD shock burden, healthcare utilization, and patient-reported quality of life. The trial aims to provide high-quality comparative data to address clinical equipoise surrounding the two commonly used beta-blockers in HFrEF management.
Study identification
- NCT ID
- NCT06964464
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 2,000 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 17, 2025 (Actual)
- Primary completion
- Jun 1, 2031 (Estimated)
- Completion
- Jul 1, 2031 (Estimated)
- Last update posted
- Sep 18, 2025
2025 – 2031
United States locations
- U.S. sites
- 13
- U.S. states
- 11
- U.S. cities
- 12
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| HonorHealth | Scottsdale | Arizona | 85258 | Recruiting |
| AdventHealth Redmond | Rome | Georgia | 30165 | Recruiting |
| AdventHealth Shawnee Mission | Shawnee Mission | Kansas | 66204 | Recruiting |
| Henry Ford Health System | Detroit | Michigan | 48202 | Recruiting |
| University of Mossouri | Columbia | Missouri | 65212 | Recruiting |
| Creighton University Medical Center | Omaha | Nebraska | 68124 | Recruiting |
| Suny Downstate | Brooklyn | New York | 11203 | Recruiting |
| New York-Presbyterian Brooklyn Methodist Hospital | Brooklyn | New York | 11215 | Recruiting |
| University of Rochester Medical Center | Rochester | New York | 14642 | Recruiting |
| CHRISTUS Trinity Mother Frances Health System | Tyler | Texas | 75701 | Recruiting |
| Health University of Utah | Salt Lake City | Utah | 84112 | Recruiting |
| Virginia Commonwealth University | Richmond | Virginia | 23298 | Recruiting |
| University of Wisconsin Hospital and Clinics | Madison | Wisconsin | 53792 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06964464, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 18, 2025 · Synced Oct 26, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06964464 live on ClinicalTrials.gov.