ClinicalTrials.gov record
A Clinical Study of Sacituzumab Tirumotecan (Sac-TMT, MK-2870) in People With Breast Cancer (MK-2870-032)
ClinicalTrials.gov ID: NCT06966700
Public ClinicalTrials.gov record NCT06966700. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 6, 2026, 8:54 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Open-label Study to Evaluate the Efficacy and Safety of Sac-TMT (Sacituzumab Tirumotecan, MK-2870) Followed by Carboplatin/Paclitaxel vs Chemotherapy, Both in Combination With Pembrolizumab as Neoadjuvant Therapy for High-Risk, Early-Stage, Triple-Negative Breast Cancer or Hormone Receptor-low Positive/Human Epidermal Growth Factor Receptor-2 Negative Breast Cancer
Study identification
- NCT ID
- NCT06966700
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 2,400 participants
Conditions and interventions
Conditions
Interventions
- Capecitabine Drug
- Carboplatin Drug
- Cyclophosphamide Drug
- Doxorubicin Drug
- Epirubicin Drug
- Olaparib Drug
- Paclitaxel Drug
- Pembrolizumab Biological
- Rescue Medication Drug
- Sacituzumab tirumotecan Biological
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 29, 2025
- Primary completion
- Mar 22, 2033
- Completion
- Dec 28, 2034
- Last update posted
- Apr 16, 2026
2025 – 2034
United States locations
- U.S. sites
- 49
- U.S. states
- 22
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Banner MD Anderson Cancer Center ( Site 0066) | Gilbert | Arizona | 85234 | Recruiting |
| Mayo Clinic Cancer Center ( Site 0034) | Phoenix | Arizona | 85054 | Recruiting |
| University of Arizona Cancer Center ( Site 0035) | Tucson | Arizona | 85719 | Recruiting |
| Roy and Patricia Disney Family Cancer Center ( Site 0055) | Burbank | California | 91505 | Recruiting |
| Providence Medical Foundation ( Site 0080) | Fullerton | California | 92835 | Recruiting |
| Hoag Memorial Hospital Presbyterian ( Site 0010) | Newport Beach | California | 92663 | Recruiting |
| Helios Clinical Research ( Site 0061) | Whittier | California | 90602 | Recruiting |
| Intermountain Health Cancer Center Saint Joseph ( Site 0062) | Denver | Colorado | 80218 | Recruiting |
| Intermountain Health St. Mary's Regional Hospital ( Site 0054) | Grand Junction | Colorado | 81501 | Recruiting |
| AdventHealth Medical Group Oncology and Hematology at Altamonte ( Site 0044) | Altamonte Springs | Florida | 32701 | Recruiting |
| Florida Cancer Specialists - South ( Site 7004) | Fort Myers | Florida | 33901 | Recruiting |
| Bioresearch Partner ( Site 0072) | Hialeah | Florida | 33013 | Recruiting |
| Mayo Clinic Hospital ( Site 0013) | Jacksonville | Florida | 32224 | Recruiting |
| Florida Cancer Specialists - North ( Site 7002) | St. Petersburg | Florida | 33701 | Recruiting |
| Fort Wayne Medical Oncology and Hematology ( Site 0084) | Fort Wayne | Indiana | 46804 | Recruiting |
| Franciscan Health ( Site 0077) | Indianapolis | Indiana | 46237 | Recruiting |
| Ochsner Clinic Foundation ( Site 0021) | New Orleans | Louisiana | 70121 | Recruiting |
| Louisiana State University Health Sciences Shreveport ( Site 0053) | Shreveport | Louisiana | 71103 | Recruiting |
| New England Cancer Specialists ( Site 0051) | Westbrook | Maine | 04092 | Recruiting |
| Mercy Medical Center - Baltimore ( Site 0015) | Baltimore | Maryland | 21202 | Recruiting |
| Saint Luke's Cancer Institute ( Site 0059) | Kansas City | Missouri | 64111 | Recruiting |
| Washington University Siteman Cancer Center ( Site 0031) | St Louis | Missouri | 63110 | Recruiting |
| Cancer Partners of Nebraska ( Site 0068) | Lincoln | Nebraska | 68516 | Recruiting |
| Optum Care Cancer Center ( Site 0050) | Las Vegas | Nevada | 89102 | Recruiting |
| Renown Regional Medical Center ( Site 0041) | Reno | Nevada | 89502 | Recruiting |
| Hackensack Univ Medical Center (HUMC) ( Site 0007) | Hackensack | New Jersey | 07601 | Recruiting |
| Rutgers Cancer Institute of New Jersey ( Site 0076) | New Brunswick | New Jersey | 08901 | Recruiting |
| Altru Health System ( Site 0057) | Grand Forks | North Dakota | 58201 | Recruiting |
| Good Samaritan Hospital-TriHealth Cancer institute ( Site 0027) | Cincinnati | Ohio | 45220 | Recruiting |
| Medical University of South Carolina-Hollings Cancer Center ( Site 0016) | Charleston | South Carolina | 29425 | Recruiting |
| St Francis Cancer Center ( Site 0093) | Greenville | South Carolina | 29607 | Recruiting |
| Avera McKennan Hospital ( Site 0002) | Sioux Falls | South Dakota | 57105 | Recruiting |
| Avera Cancer Institute - Yankton ( Site 0089) | Yankton | South Dakota | 57078 | Recruiting |
| Tennessee Cancer Specialists ( Site 7001) | Knoxville | Tennessee | 37909 | Recruiting |
| Nashville General Hospital ( Site 0017) | Nashville | Tennessee | 37208 | Recruiting |
| Vanderbilt-Ingram Cancer Center ( Site 0038) | Nashville | Tennessee | 37232 | Recruiting |
| Hendrick Medical Center ( Site 0009) | Abilene | Texas | 79601 | Recruiting |
| JPS Oncology and Infusion Center ( Site 0083) | Fort Worth | Texas | 76104 | Recruiting |
| Kelsey-Seybold Clinic ( Site 0042) | Houston | Texas | 77025 | Recruiting |
| Kelsey-Seybold Clinic ( Site 0088) | Houston | Texas | 77025 | Recruiting |
| Oncology Consultants P.A. ( Site 0073) | Houston | Texas | 77030 | Recruiting |
| Texas Oncology - San Antonio ( Site 8004) | San Antonio | Texas | 78240 | Recruiting |
| Intermountain Medical Center ( Site 0074) | Murray | Utah | 84107 | Recruiting |
| Bon Secours Cancer Institute at St. Francis ( Site 0048) | Midlothian | Virginia | 23114 | Recruiting |
| Oncology and Hematology Associates of Southwest Virginia (BRCC) ( Site 8005) | Roanoke | Virginia | 24014 | Recruiting |
| Fred Hutchinson Cancer Center ( Site 0069) | Seattle | Washington | 98109 | Recruiting |
| Cancer Care Northwest ( Site 0003) | Spokane | Washington | 99202 | Recruiting |
| Northwest Medical Specialties, PLLC ( Site 0067) | Tacoma | Washington | 98405 | Recruiting |
| University of Wisconsin-Madison ( Site 0024) | Madison | Wisconsin | 53792 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 219 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06966700, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 16, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06966700 live on ClinicalTrials.gov.