Comparative Effectiveness of Migraine Preventive Medications: The APT Comparison Study
Public ClinicalTrials.gov record NCT06972056. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Comparative Effectiveness Study of Oral Medications Used for Migraine Prevention: The APT Comparison Study
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This goal of this study is to compare three medications used for migraine preventive treatment. This study will compare atogepant, a newer migraine preventive medication, with two older preventive medications, topiramate and propranolol. It will be determined if one works better and is more tolerable than the others. Research participants will: * Be randomly assigned to one of the three medications. * Provide information about their migraine pattern using a daily headache diary and during research visits.
Study identification
- NCT ID
- NCT06972056
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 1,335 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years to 70 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 8, 2025
- Primary completion
- Feb 28, 2029
- Completion
- Nov 30, 2029
- Last update posted
- Sep 15, 2026
2025 – 2029
United States locations
- U.S. sites
- 36
- U.S. states
- 22
- U.S. cities
- 32
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Northern Arizona Healthcare | Flagstaff | Arizona | 86001 | Recruiting |
| Mayo Clinic Arizona | Phoenix | Arizona | 85054 | Recruiting |
| Keck School of Medicine of USC | Los Angeles | California | 90033 | Recruiting |
| Clinical Research Institute | Los Angeles | California | 90048 | Recruiting |
| Desert Physicians Medical Group | Palm Springs | California | 92262 | Recruiting |
| The Neurology Group | Pomona | California | 91767 | Recruiting |
| University of Colorado Anschutz Medical Campus | Aurora | Colorado | 80045 | Recruiting |
| Memorial Healthcare | Hollywood | Florida | 33021 | Recruiting |
| Mayo Clinic Florida | Jacksonville | Florida | 32066 | Recruiting |
| Apple Med Research | Miami | Florida | 33126 | Recruiting |
| University of Miami | Miami | Florida | 33136 | Recruiting |
| Neuroscience Research Center | Overland Park | Kansas | 66210 | Recruiting |
| Clinical Trials of New England | Hyde Park | Massachusetts | 02136 | Recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905 | Recruiting |
| Washington University St Louis | St Louis | Missouri | 63110 | Recruiting |
| Nebraska Medical Center | Omaha | Nebraska | 68198 | Recruiting |
| Advanced Research Institute Reno | Reno | Nevada | 89511 | Recruiting |
| JFK Neuroscience Institute | Edison | New Jersey | 08820 | Recruiting |
| Nuvance Health Institute | Kingston | New York | 12401 | Recruiting |
| Northwell Health | Manhasset | New York | 11030 | Recruiting |
| Mt Sinai Icahn School of Medicine | New York | New York | 10029 | Recruiting |
| Onsite Clinical Solutions Park Cedar Dr. | Charlotte | North Carolina | 28210 | Recruiting |
| Onsite Clinical Solutions Mecklenburg | Charlotte | North Carolina | 28211 | Recruiting |
| Onsite Clinical Solutions Ballantyne | Charlotte | North Carolina | 28277 | Recruiting |
| Onsite Clinical Solutions Salisbury | Salisbury | North Carolina | 28144 | Recruiting |
| Wake Forest University Health | Winston-Salem | North Carolina | 27157 | Recruiting |
| Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | Recruiting |
| Advanced Research Institute | Portland | Oregon | 97223 | Recruiting |
| University of Pennsylvania | Philadelphia | Pennsylvania | 19107 | Recruiting |
| Brown University Health | Providence | Rhode Island | 02903 | Recruiting |
| Vanderbilt Medical Center | Nashville | Tennessee | 37215 | Recruiting |
| DHR Health Headache Center | McAllen | Texas | 78504 | Recruiting |
| Advanced Research Institute Ogden | Ogden | Utah | 84405 | Recruiting |
| West Virginia University | Morgantown | West Virginia | 26506 | Recruiting |
| Marshfield Clinic Research Institute | Marshfield | Wisconsin | 54449 | Recruiting |
| The Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06972056, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 15, 2026 · Synced Sep 16, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06972056 live on ClinicalTrials.gov.