A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
Public ClinicalTrials.gov record NCT06976203. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for the Treatment of Cognitive Impairment Associated With Mild to Moderate Alzheimer's Disease (MINDSET 2)
Study identification
- NCT ID
- NCT06976203
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Bristol-Myers Squibb
- Industry
- Enrollment
- 586 participants
Conditions and interventions
Conditions
Interventions
- KarX-EC Drug
- KarXT Drug
- Placebo Other
Drug · Other
Eligibility (public fields only)
- Age range
- 60 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 20, 2025
- Primary completion
- Sep 10, 2028
- Completion
- Feb 22, 2029
- Last update posted
- Apr 30, 2026
2025 – 2029
United States locations
- U.S. sites
- 30
- U.S. states
- 13
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Fullerton Neurology and Headache Center | Fullerton | California | 92835 | Recruiting |
| Inglewood Clinical | Inglewood | California | 90301 | Recruiting |
| Irvine Clinical Research | Irvine | California | 92614 | Recruiting |
| Local Institution - 0083 | Palo Alto | California | 94304 | Not yet recruiting |
| Local Institution - 0069 | San Diego | California | 92103 | Withdrawn |
| Research of the Rockies | Colorado Springs | Colorado | 80919 | Recruiting |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | Recruiting |
| Velocity Clinical Research, Hallandale Beach | Hallandale | Florida | 33009 | Recruiting |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | Recruiting |
| K2 MEDICAL Research THE VILLAGES | Lady Lake | Florida | 32159 | Recruiting |
| Intercoastal Medical Group | Sarasota | Florida | 34239 | Recruiting |
| USF Health Byrd Alzheimer's Institute | Tampa | Florida | 33613 | Recruiting |
| Alzheimer's Research and Treatment Center | Wellington | Florida | 33414 | Recruiting |
| Great Lakes Clinical Trials - Andersonville | Chicago | Illinois | 60640 | Recruiting |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | Recruiting |
| Josephson Wallack Munshower Neurology, PC | Indianapolis | Indiana | 46256 | Recruiting |
| Local Institution - 0080 | Watertown | Massachusetts | 02472 | Not yet recruiting |
| QUEST Research Institute | Farmington Hills | Michigan | 48334 | Recruiting |
| Private Practice - Dr. Ronald Louis Schwartz | Hattiesburg | Mississippi | 39401 | Recruiting |
| Local Institution - 0119 | Ridgewood | New Jersey | 07450 | Withdrawn |
| The Cognitive and Research Center of New Jersey | Springfield | New Jersey | 07081 | Recruiting |
| Advanced Clinical Institute | West Long Branch | New Jersey | 07764 | Recruiting |
| Neurological Associates Albany | Albany | New York | 12208 | Recruiting |
| Dent Neurosciences Research Center, Inc | Amherst | New York | 14226 | Recruiting |
| University at Buffalo - UBMD Neurology | Buffalo | New York | 14203 | Recruiting |
| Local Institution - 0078 | Lake Success | New York | 11042 | Withdrawn |
| Keystone Clinical Studies | Plymouth Meeting | Pennsylvania | 19462 | Recruiting |
| Local Institution - 0081 | Dallas | Texas | 75231 | Not yet recruiting |
| Central Texas Neurology Consultants, PA | Round Rock | Texas | 78681 | Recruiting |
| Rainier Clinical Research Center | Renton | Washington | 98057 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 92 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06976203, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 30, 2026 · Synced May 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06976203 live on ClinicalTrials.gov.