A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease (MINDSET 2)
Public ClinicalTrials.gov record NCT06976203. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for the Treatment of Cognitive Impairment Associated With Mild to Moderate Alzheimer's Disease (MINDSET 2)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the efficacy and safety of KarXT + KarX-EC for cognitive impairment in Alzheimer's Disease
Study identification
- NCT ID
- NCT06976203
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 586 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 60 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 20, 2025
- Primary completion
- Sep 10, 2028
- Completion
- Feb 22, 2029
- Last update posted
- Aug 11, 2026
2025 – 2029
United States locations
- U.S. sites
- 30
- U.S. states
- 13
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Fullerton Neurology and Headache Center | Fullerton | California | 92835 | Recruiting |
| Irvine Clinical Research | Irvine | California | 92614 | Recruiting |
| Inglewood Clinical | Los Angeles | California | 90056 | Recruiting |
| Stanford Neuroscience Health Center | Palo Alto | California | 94304 | Recruiting |
| Local Institution - 0069 | San Diego | California | 92103 | Withdrawn |
| Research of the Rockies | Colorado Springs | Colorado | 80919 | Recruiting |
| Neuropsychiatric Research Center of Southwest Florida | Fort Myers | Florida | 33912 | Recruiting |
| Local Institution - 0086 | Hallandale | Florida | 33009 | Completed |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | Recruiting |
| K2 MEDICAL Research THE VILLAGES | Lady Lake | Florida | 32159 | Recruiting |
| Intercoastal Medical Group | Sarasota | Florida | 34239 | Recruiting |
| USF Health Byrd Alzheimer's Institute | Tampa | Florida | 33613 | Recruiting |
| Alzheimer's Research and Treatment Center | Wellington | Florida | 33414 | Recruiting |
| Great Lakes Clinical Trials - Andersonville | Chicago | Illinois | 60640 | Recruiting |
| Southern Illinois University School of Medicine | Springfield | Illinois | 62702 | Recruiting |
| Josephson Wallack Munshower Neurology, PC | Indianapolis | Indiana | 46256 | Recruiting |
| Local Institution - 0080 | Watertown | Massachusetts | 02472 | Not yet recruiting |
| QUEST Research Institute | Farmington Hills | Michigan | 48334 | Recruiting |
| Private Practice - Dr. Ronald Louis Schwartz | Hattiesburg | Mississippi | 39401 | Recruiting |
| Local Institution - 0119 | Ridgewood | New Jersey | 07450 | Withdrawn |
| The Cognitive and Research Center of New Jersey | Springfield | New Jersey | 07081 | Recruiting |
| Advanced Clinical Institute | West Long Branch | New Jersey | 07764 | Recruiting |
| Neurological Associates Albany | Albany | New York | 12208 | Recruiting |
| Dent Neurosciences Research Center, Inc | Amherst | New York | 14226 | Recruiting |
| University at Buffalo - UBMD Neurology | Buffalo | New York | 14203 | Recruiting |
| Local Institution - 0078 | Lake Success | New York | 11042 | Withdrawn |
| Keystone Clinical Studies | Plymouth Meeting | Pennsylvania | 19462 | Recruiting |
| Local Institution - 0081 | Dallas | Texas | 75231 | Not yet recruiting |
| Central Texas Neurology Consultants, PA | Round Rock | Texas | 78681 | Recruiting |
| Local Institution - 0076 | Renton | Washington | 98057 | Completed |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 95 non-U.S. sites.
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About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06976203, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 11, 2026 · Synced Aug 27, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06976203 live on ClinicalTrials.gov.