A Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for Cognitive Impairment in Alzheimer's Disease
Public ClinicalTrials.gov record NCT06976216. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy and Safety of KarXT + KarX-EC for the Treatment of Cognitive Impairment Associated With Mild to Moderate Alzheimer's Disease (MINDSET 1)
Study identification
- NCT ID
- NCT06976216
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Bristol-Myers Squibb
- Industry
- Enrollment
- 586 participants
Conditions and interventions
Conditions
Interventions
- KarX-EC Drug
- KarXT Drug
- Placebo Other
Drug · Other
Eligibility (public fields only)
- Age range
- 60 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 13, 2025
- Primary completion
- Sep 10, 2028
- Completion
- Feb 22, 2029
- Last update posted
- May 6, 2026
2025 – 2029
United States locations
- U.S. sites
- 28
- U.S. states
- 17
- U.S. cities
- 27
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Healthy Brain Clinic | Long Beach | California | 90804 | Recruiting |
| Anderson Clinical Research | Redlands | California | 92374 | Recruiting |
| Mountain Neurological Research Center | Basalt | Colorado | 81621 | Recruiting |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | Recruiting |
| JEM Research Institute | Atlantis | Florida | 33462 | Recruiting |
| VIN-Julie Schwartzbard | Aventura | Florida | 33180 | Recruiting |
| Merritt Island Medical Research, LLC | Merritt Island | Florida | 32952 | Recruiting |
| Renstar Medical Research | Ocala | Florida | 34470 | Recruiting |
| Alzheimer's Research and Treatment Center | Stuart | Florida | 34997 | Recruiting |
| Charter Research - Lady Lake | The Villages | Florida | 32162 | Recruiting |
| Local Institution - 0016 | Columbus | Georgia | 31909 | Withdrawn |
| Center for Advanced Research & Education | Gainesville | Georgia | 30501 | Recruiting |
| Re:Cognition Health - Chicago | Chicago | Illinois | 60611 | Recruiting |
| Ascension Alexian Brothers | Elk Grove Village | Illinois | 60007 | Recruiting |
| Boston Center for Memory | Newton | Massachusetts | 02459 | Recruiting |
| HealthPartners Neuroscience Center | Saint Paul | Minnesota | 55130 | Recruiting |
| Advanced Memory Research Institute of New Jersey | Toms River | New Jersey | 08755 | Recruiting |
| NYU Langone Health | New York | New York | 10016 | Recruiting |
| Local Institution - 0259 | New York | New York | 10029 | Active, not recruiting |
| SUNY Upstate Medical University | Syracuse | New York | 13210 | Recruiting |
| AMC Research, LLC | Matthews | North Carolina | 28105 | Recruiting |
| Ohio State University | Columbus | Ohio | 43221 | Recruiting |
| NDx Clinical Research Inc. | Dayton | Ohio | 45459 | Recruiting |
| Summit Headlands | Portland | Oregon | 97210 | Recruiting |
| Local Institution - 0004 | Abington | Pennsylvania | 19001 | Withdrawn |
| Rhode Island Mood & Memory Research Institute | East Providence | Rhode Island | 02914 | Recruiting |
| Neurology Clinic, P.C. | Cordova | Tennessee | 38018 | Recruiting |
| Gadolin Research | Beaumont | Texas | 77702 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 77 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06976216, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 6, 2026 · Synced May 10, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06976216 live on ClinicalTrials.gov.