ClinicalTrials.gov record
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
ClinicalTrials.gov ID: NCT06989437
Public ClinicalTrials.gov record NCT06989437. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b/3, Randomized, Double-Blind Study to Investigate the Efficacy, Safety, and Tolerability of Ponsegromab (PF-06946860) Compared With Placebo Both With Background First-Line Chemotherapy in Adult Participants With Cachexia and Metastatic Pancreatic Ductal Adenocarcinoma
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Study to investigate the efficacy, safety and tolerability of systemic chemotherapy plus ponsegromab versus systemic chemotherapy plus placebo for the first-line treatment in adult participants with cachexia and metastatic pancreatic ductal adenocardinoma.
Study identification
- NCT ID
- NCT06989437
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 982 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 2, 2025
- Primary completion
- Jan 16, 2028
- Completion
- Dec 9, 2029
- Last update posted
- Aug 23, 2026
2025 – 2029
United States locations
- U.S. sites
- 83
- U.S. states
- 23
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The Kirklin Clinic of UAB Hospital | Birmingham | Alabama | 35233 | Recruiting |
| The University of Alabama at Birmingham | Birmingham | Alabama | 35294 | Recruiting |
| Mayo Clinic Hospital | Phoenix | Arizona | 85054 | Recruiting |
| Central Arkansas Radiation Therapy Institute, dba CARTI | Bryant | Arkansas | 72022 | Recruiting |
| Central Arkansas Radiation Therapy Institute, dba CARTI | Conway | Arkansas | 72034 | Recruiting |
| CARTI Cancer Center | Little Rock | Arkansas | 72205 | Recruiting |
| Central Arkansas Radiation Therapy Institute, dba CARTI | North Little Rock | Arkansas | 72117 | Recruiting |
| Central Arkansas Radiation Therapy Institute, dba CARTI | Pine Bluff | Arkansas | 71603 | Recruiting |
| UC San Diego Medical Center - Encinitas | Encinitas | California | 92024 | Recruiting |
| Chao Family Comprehensive Cancer Center and Ambulatory Care | Irvine | California | 92612 | Recruiting |
| UCI Health - Irvine | Irvine | California | 92612 | Recruiting |
| UC San Diego Koman Family Outpatient Pavilion | La Jolla | California | 92037 | Recruiting |
| UC San Diego Medical Center - La Jolla (Jacobs Medical Center / Thornton Pavilion) | La Jolla | California | 92037 | Recruiting |
| UC San Diego Moores Cancer Center | La Jolla | California | 92037 | Recruiting |
| UC San Diego Sulpizio Cardiovascular Center | La Jolla | California | 92037 | Recruiting |
| Cedars-Sinai Cancer at Cedars-Sinai Medical Center | Los Angeles | California | 90048 | Recruiting |
| UCLA Department of Medicine - Hematology/Oncology | Los Angeles | California | 90095 | Recruiting |
| UC Irvine Health | Orange | California | 92868 | Recruiting |
| UC San Diego Medical Center - Bankers Hill | San Diego | California | 92101 | Recruiting |
| UC San Diego McGrath Outpatient Pavilion - Hillcrest | San Diego | California | 92103 | Recruiting |
| UC San Diego Medical Center - Hillcrest | San Diego | California | 92103 | Recruiting |
| UC San Diego Medical Center - Rancho Bernardo | San Diego | California | 92127 | Recruiting |
| UCLA Hematology/Oncology - Santa Monica | Santa Monica | California | 90404 | Recruiting |
| Providence Medical Foundation | Santa Rosa | California | 95403 | Recruiting |
| UC San Diego Medical Center - Vista | Vista | California | 92081 | Recruiting |
| Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy | Washington D.C. | District of Columbia | 20007 | Recruiting |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | Recruiting |
| Mayo Clinic Pharmacy | Jacksonville | Florida | 32224 | Recruiting |
| Mayo Clinic | Jacksonville | Florida | 32224 | Recruiting |
| University Cancer & Blood Center, LLC | Athens | Georgia | 30607 | Recruiting |
| Invision, LLC | Honolulu | Hawaii | 96813 | Recruiting |
| University of Hawaii Cancer Center | Honolulu | Hawaii | 96813 | Recruiting |
| Cardiology Associates, Inc | ‘Aiea | Hawaii | 96701 | Recruiting |
| Cancer Care Specialists of Illinois | Decatur | Illinois | 62526 | Recruiting |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | Recruiting |
| Hope and Healing Clinical Research LLC | Hinsdale | Illinois | 60521 | Recruiting |
| Hope and Healing Clinical Research LLC New Lenox- Research Department | New Lenox | Illinois | 60451 | Recruiting |
| Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | Recruiting |
| United Imaging Consultants | Lenexa | Kansas | 66215 | Recruiting |
| MidAmerica Cancer Care- American Oncology Partners | Merriam | Kansas | 66204 | Recruiting |
| University of Kentucky Research Foundation | Lexington | Kentucky | 40506 | Recruiting |
| University of Kentucky Healthcare - Markey Cancer Center | Lexington | Kentucky | 40536 | Recruiting |
| University of Kentucky Medical Center | Lexington | Kentucky | 40536 | Recruiting |
| University of Kentucky, Markey Cancer Center Clinical Research Office (UK MCC CRO) | Lexington | Kentucky | 40536 | Recruiting |
| JHU Oncology Central Kit Services | Baltimore | Maryland | 21205 | Recruiting |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | Recruiting |
| Oncology Investigational Drug Service (IDS) | Baltimore | Maryland | 21287 | Recruiting |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | 21287 | Recruiting |
| Mayo Clinic Cancer Center Outpatient Pharmacy | Rochester | Minnesota | 55905 | Recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905 | Recruiting |
| Premier Imaging | Kansas City | Missouri | 64114 | Recruiting |
| St. Joseph Medical Center | Kansas City | Missouri | 64114 | Recruiting |
| MidAmerica Cancer Care - American Oncology Partners | Kansas City | Missouri | 64132 | Recruiting |
| Nebraska Medicine | Omaha | Nebraska | 68105 | Recruiting |
| Nebraska Medicine - Village Pointe | Omaha | Nebraska | 68118 | Recruiting |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | Recruiting |
| Renown Health Medical Oncology | Reno | Nevada | 89502 | Recruiting |
| Renown Office of Clinical Research | Reno | Nevada | 89502 | Recruiting |
| Renown Regional Medical Center | Reno | Nevada | 89502 | Recruiting |
| Atlantic Health System / Morristown Medical Center | Morristown | New Jersey | 07960 | Recruiting |
| Jack & Sheryl Morris Cancer Center | New Brunswick | New Jersey | 08901 | Recruiting |
| Rutgers Cancer Institute | New Brunswick | New Jersey | 08901 | Recruiting |
| RWJ University Hospital Somerset, Steeplechase Cancer Center | Somerville | New Jersey | 08876 | Recruiting |
| Rwj University Hospital Somerset | Somerville | New Jersey | 08876 | Recruiting |
| Atlantic Health System / Overlook Medical Center | Summit | New Jersey | 07901 | Recruiting |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | Recruiting |
| University of Rochester Medical Center | Rochester | New York | 14642 | Recruiting |
| UNC Hospitals, The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | Recruiting |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | Not yet recruiting |
| University of North Carolina Hospitals at Hillsborough | Hillsborough | North Carolina | 27278 | Recruiting |
| OHSU Center for Health & Healing 1 | Portland | Oregon | 97239 | Recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239 | Recruiting |
| OSHU Center for Health and Healing 2 | Portland | Oregon | 97239 | Recruiting |
| University of Texas Southwestern Medical Center - Simmons Cancer Center | Dallas | Texas | 75235 | Recruiting |
| University of Texas Southwestern Medical Center-William P. Clements Jr. University Hospital | Dallas | Texas | 75235 | Recruiting |
| University of Texas Southwestern Medical Center-Zale Lipshy University Hospital | Dallas | Texas | 75390 | Recruiting |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| Houston Methodist Hospital | Houston | Texas | 77030 | Recruiting |
| Baylor Scott & White Vasicek Cancer Treatment Center | Temple | Texas | 76508 | Recruiting |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | Recruiting |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | Recruiting |
| University of Washington Medical Center | Seattle | Washington | 98195 | Recruiting |
| Froedtert Hospital and the Medical College of Wisconsin | Milwaukee | Wisconsin | 53226 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 137 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06989437, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 23, 2026 · Synced Sep 2, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06989437 live on ClinicalTrials.gov.