ClinicalTrials.gov record
A Study to Learn About the Medicine Ponsegromab in Adults With Cancer of the Pancreas Which Has Spread and Caused Significant Body Weight Loss and Fatigue
ClinicalTrials.gov ID: NCT06989437
Public ClinicalTrials.gov record NCT06989437. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 10, 2026, 8:17 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2b/3, Randomized, Double-Blind Study to Investigate the Efficacy, Safety, and Tolerability of Ponsegromab (PF-06946860) Compared With Placebo Both With Background First-Line Chemotherapy in Adult Participants With Cachexia and Metastatic Pancreatic Ductal Adenocarcinoma
Study identification
- NCT ID
- NCT06989437
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 982 participants
Conditions and interventions
Interventions
- placebo Drug
- ponsegromab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 2, 2025
- Primary completion
- Jan 16, 2028
- Completion
- Dec 9, 2029
- Last update posted
- May 4, 2026
2025 – 2029
United States locations
- U.S. sites
- 45
- U.S. states
- 16
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The Kirklin Clinic of UAB Hospital | Birmingham | Alabama | 35233 | Not yet recruiting |
| The University of Alabama at Birmingham | Birmingham | Alabama | 35294 | Not yet recruiting |
| Central Arkansas Radiation Therapy Institute, dba CARTI | Bryant | Arkansas | 72022 | Not yet recruiting |
| Central Arkansas Radiation Therapy Institute, dba CARTI | Conway | Arkansas | 72034 | Not yet recruiting |
| CARTI Cancer Center | Little Rock | Arkansas | 72205 | Not yet recruiting |
| Central Arkansas Radiation Therapy Institute, dba CARTI | North Little Rock | Arkansas | 72117 | Not yet recruiting |
| Central Arkansas Radiation Therapy Institute, dba CARTI | Pine Bluff | Arkansas | 71603 | Not yet recruiting |
| Cedars-Sinai Cancer at Cedars-Sinai Medical Center | Los Angeles | California | 90048 | Recruiting |
| UCLA Department of Medicine - Hematology/Oncology | Los Angeles | California | 90095 | Not yet recruiting |
| UCLA Hematology/Oncology - Santa Monica | Santa Monica | California | 90404 | Not yet recruiting |
| Providence Medical Foundation | Santa Rosa | California | 95403 | Not yet recruiting |
| Georgetown University Medical Center - Department of Pharmacy, Oncology Pharmacy | Washington D.C. | District of Columbia | 20007 | Not yet recruiting |
| Georgetown University Medical Center | Washington D.C. | District of Columbia | 20007 | Not yet recruiting |
| University Cancer & Blood Center, LLC | Athens | Georgia | 30607 | Recruiting |
| Invision, LLC | Honolulu | Hawaii | 96813 | Recruiting |
| University of Hawaii Cancer Center | Honolulu | Hawaii | 96813 | Recruiting |
| Cardiology Associates, Inc | ‘Aiea | Hawaii | 96701 | Recruiting |
| Cancer Care Specialists of Illinois | Decatur | Illinois | 62526 | Recruiting |
| Decatur Memorial Hospital | Decatur | Illinois | 62526 | Recruiting |
| Hope and Healing Cancer Services | Hinsdale | Illinois | 60521 | Not yet recruiting |
| Hope and Healing Cancer Services New Lenox | New Lenox | Illinois | 60451 | Not yet recruiting |
| Cancer Care Specialists of Illinois - Cancer Care Center of O'Fallon | O'Fallon | Illinois | 62269 | Recruiting |
| University of Kentucky Research Foundation | Lexington | Kentucky | 40506 | Not yet recruiting |
| University of Kentucky Healthcare - Markey Cancer Center | Lexington | Kentucky | 40536 | Not yet recruiting |
| University of Kentucky Medical Center | Lexington | Kentucky | 40536 | Not yet recruiting |
| University of Kentucky, Markey Cancer Center Clinical Research Office (UK MCC CRO) | Lexington | Kentucky | 40536 | Not yet recruiting |
| JHU Oncology Central Kit Services | Baltimore | Maryland | 21205 | Not yet recruiting |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | Not yet recruiting |
| Oncology Investigational Drug Service (IDS) | Baltimore | Maryland | 21287 | Not yet recruiting |
| Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Baltimore | Maryland | 21287 | Not yet recruiting |
| Nebraska Medicine | Omaha | Nebraska | 68105 | Not yet recruiting |
| Nebraska Medicine - Village Pointe | Omaha | Nebraska | 68118 | Not yet recruiting |
| University of Nebraska Medical Center | Omaha | Nebraska | 68198 | Not yet recruiting |
| Renown Health Medical Oncology | Reno | Nevada | 89502 | Recruiting |
| Renown Office of Clinical Research | Reno | Nevada | 89502 | Recruiting |
| Renown Regional Medical Center | Reno | Nevada | 89502 | Recruiting |
| University of Rochester Medical Center | Rochester | New York | 14642 | Not yet recruiting |
| UNC Hospitals, The University of North Carolina at Chapel Hill | Chapel Hill | North Carolina | 27514 | Not yet recruiting |
| University of North Carolina Hospitals at Hillsborough | Hillsborough | North Carolina | 27278 | Not yet recruiting |
| OHSU Center for Health & Healing 1 | Portland | Oregon | 97239 | Not yet recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239 | Not yet recruiting |
| OSHU Center for Health and Healing 2 | Portland | Oregon | 97239 | Not yet recruiting |
| Houston Methodist Hospital | Houston | Texas | 77030 | Not yet recruiting |
| Baylor Scott & White Vasicek Cancer Treatment Center | Temple | Texas | 76508 | Not yet recruiting |
| Virginia Mason Medical Center | Seattle | Washington | 98101 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 80 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06989437, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 4, 2026 · Synced May 10, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06989437 live on ClinicalTrials.gov.