BoxX-NoAF Clinical Trial
Public ClinicalTrials.gov record NCT06989775. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
EnCompass Clamp and the AtriClip in Box Lesion and Left Atrial Appendage EXclusion Procedure for the Prevention of New Onset of Atrial Fibrillation
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
Post Operative Atrial Fibrillation (POAF) is the most common complication of cardiac surgery. POAF incidence can exceed 50% depending on the patient baseline characteristics and surgery type. Patients with POAF tend to have worse acute and long-term clinical outcomes. BoxX-NoAF is a randomized trial to evaluate if prophylactic ablation and exclusion of the Left Atrial Appendage at the time of other routine cardiac surgery can reduce the incidence of post operative AF and clinical AF during long term follow up in patients who have not yet developed AF but are at risk.
Study identification
- NCT ID
- NCT06989775
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Not applicable
- Enrollment
- 960 participants
Conditions and interventions
Interventions
Device
Eligibility (public fields only)
- Age range
- 65 Years and older
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 24, 2025 (Actual)
- Primary completion
- Feb 2027 (Estimated)
- Completion
- Dec 2029 (Estimated)
- Last update posted
- Oct 7, 2026
2025 – 2029
United States locations
- U.S. sites
- 33
- U.S. states
- 18
- U.S. cities
- 30
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Honor Health | Scottsdale | Arizona | 85258 | Recruiting |
| St. Bernards Medical Center | Jonesboro | Arkansas | 72401 | Recruiting |
| Sharp Memorial Hospital | San Diego | California | 92123 | Recruiting |
| Adventist Health St. Helena | St. Helena | California | 94574 | Recruiting |
| Morton Plant Hospital - BayCare Health System, Inc. | Clearwater | Florida | 33759 | Recruiting |
| St. Joseph's Hospital - BayCare Health System, Inc. | Clearwater | Florida | 33759 | Recruiting |
| Naples Comprehensive Health | Naples | Florida | 34102 | Recruiting |
| Orlando Health, Inc. | Orlando | Florida | 32806 | Recruiting |
| Sarasota Memorial Hospital | Sarasota | Florida | 34239 | Recruiting |
| Emory University | Atlanta | Georgia | 30308 | Recruiting |
| Piedmont Hospital | Atlanta | Georgia | 30309 | Recruiting |
| Wellstar Health System | Marietta | Georgia | 30062 | Recruiting |
| Northwestern Memorial Hospital | Chicago | Illinois | 60611 | Recruiting |
| Norton Healthcare | Louisville | Kentucky | 40205 | Recruiting |
| MedStar Health Research Institute | Baltimore | Maryland | 21218 | Recruiting |
| University of Michigan | Ann Arbor | Michigan | 48109 | Recruiting |
| Corewell Health | Grand Rapids | Michigan | 49503 | Recruiting |
| Trinity Health | Ypsilanti | Michigan | 48197 | Recruiting |
| Mayo Clinic | Rochester | Minnesota | 55905 | Recruiting |
| BJC Healthcare (Washington University) | St Louis | Missouri | 63110 | Recruiting |
| Northwell Health | Manhasset | New York | 11030 | Recruiting |
| New York Presbyterian Hospital/Columbia University Irving Medical Center | New York | New York | 10032 | Not yet recruiting |
| Bethesda North Hospital | Cincinnati | Ohio | 45242 | Recruiting |
| Cleveland Clinic Foundation | Cleveland | Ohio | 44195 | Recruiting |
| Promedica Toledo Hospital | Toledo | Ohio | 43614 | Recruiting |
| Allegheny-Singer Research Institute | Pittsburgh | Pennsylvania | 15212 | Recruiting |
| Centennial Medical Center | Nashville | Tennessee | 37203 | Recruiting |
| Ascension Saint Thomas | Nashville | Tennessee | 37205 | Recruiting |
| St David's HealthCare | Austin | Texas | 78705 | Recruiting |
| Baylor Research Institute - Baylor Scott and White Research Institute | Dallas | Texas | 75204 | Recruiting |
| Methodist San Antonio | San Antonio | Texas | 78229 | Withdrawn |
| Charleston Area Medical Center | Charleston | West Virginia | 25304 | Recruiting |
| Aspirus Hospital | Wausau | Wisconsin | 54401 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06989775, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 7, 2026 · Synced Oct 23, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT06989775 live on ClinicalTrials.gov.