A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)
Public ClinicalTrials.gov record NCT06991257. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF AN ORAL BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE INHIBITOR, PF-07328948, IN ADULTS WITH HEART FAILURE (BRANCH-HF)
Study identification
- NCT ID
- NCT06991257
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Pfizer
- Industry
- Enrollment
- 620 participants
Conditions and interventions
Conditions
Interventions
- High Dose PF-07328948 Drug
- Low Dose PF-07328948 Drug
- Medium Dose PF-07328948 Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 79 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 18, 2025
- Primary completion
- Nov 15, 2027
- Completion
- Dec 13, 2027
- Last update posted
- May 4, 2026
2025 – 2027
United States locations
- U.S. sites
- 28
- U.S. states
- 8
- U.S. cities
- 20
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| National Heart Institute | Beverly Hills | California | 90211 | Recruiting |
| Orange County Research Center | Lake Forest | California | 92630 | Recruiting |
| Comprehensive Cardiovascular Care | Santa Maria | California | 93454 | Recruiting |
| FOMAT Medical Research | Santa Maria | California | 93454 | Recruiting |
| FWD Clinical Research | Boca Raton | Florida | 33486 | Recruiting |
| Jacksonville Center for Clinical Research | Jacksonville | Florida | 32216 | Recruiting |
| Infinite Clinical Research | Miami | Florida | 33133 | Recruiting |
| Flourish Research Acquisition, LLC dba Flourish Research - North Miami | Miami | Florida | 33138 | Recruiting |
| Amavita Research Services | North Miami Beach | Florida | 33169 | Recruiting |
| Clinical Site Partners, LLC dba Flourish Research | Winter Park | Florida | 32789 | Recruiting |
| NMH Clinical Research Unit | Chicago | Illinois | 60611 | Recruiting |
| Northwestern Memorial HealthCare - Arkes Pavilion | Chicago | Illinois | 60611 | Recruiting |
| Northwestern Memorial HealthCare - Feinberg Pavilion | Chicago | Illinois | 60611 | Recruiting |
| Northwestern Memorial HealthCare - Galter Pavilion | Chicago | Illinois | 60611 | Recruiting |
| Northwestern Memorial Hospital Investigational Drug Service (IDS) | Chicago | Illinois | 60611 | Recruiting |
| Northwestern University | Evanston | Illinois | 60208 | Recruiting |
| Chicago Medical Research | Hazel Crest | Illinois | 60429 | Recruiting |
| NexGen Research | Fort Wayne | Indiana | 46804 | Recruiting |
| Reid Physician Associates | Richmond | Indiana | 47374 | Recruiting |
| Ascension Saint Agnes Heart Care | Baltimore | Maryland | 21229 | Recruiting |
| Chesapeake Cardiac Care | Bowie | Maryland | 20715 | Not yet recruiting |
| Flourish Research - Bowie | Bowie | Maryland | 20715 | Not yet recruiting |
| Velocity Clinical Research, Lincoln, Pioneer Heart Institute | Lincoln | Nebraska | 68510 | Recruiting |
| NexGen Research | Lima | Ohio | 45801 | Recruiting |
| Headlands Horizons, LLC dba Headlands Research-Brownsville | Brownsville | Texas | 78526 | Recruiting |
| Valley Regional Medical Center | Brownsville | Texas | 78526 | Recruiting |
| North Dallas Research Associates | McKinney | Texas | 75069 | Recruiting |
| Northwest Houston Heart Center | Tomball | Texas | 77375 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 107 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06991257, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 4, 2026 · Synced May 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06991257 live on ClinicalTrials.gov.