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Recruiting Phase 2 Interventional

A Study to Learn About the Study Medicine Called PF-07328948 in Adults With Heart Failure (BRANCH-HF)

ClinicalTrials.gov ID: NCT06991257

Public ClinicalTrials.gov record NCT06991257. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 24, 2026, 9:23 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED STUDY TO EVALUATE THE EFFICACY AND SAFETY OF AN ORAL BRANCHED-CHAIN KETOACID DEHYDROGENASE KINASE INHIBITOR, PF-07328948, IN ADULTS WITH HEART FAILURE (BRANCH-HF)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to learn about the safety and effects of the study medicine (PF-07328948) for the possible treatment of heart failure (HF).

Study identification

NCT ID
NCT06991257
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
Pfizer
Industry
Enrollment
620 participants

Conditions and interventions

Conditions

Eligibility (public fields only)

Age range
18 Years to 79 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jun 19, 2025 (Actual)
Primary completion
May 8, 2028 (Estimated)
Completion
Jun 5, 2028 (Estimated)
Last update posted
Oct 23, 2026

2025 – 2028

United States locations

U.S. sites
30
U.S. states
8
U.S. cities
21
Facility City State ZIP Site status
National Heart Institute Beverly Hills California 90211 Active, not recruiting
Orange County Research Center Lake Forest California 92630 Active, not recruiting
Comprehensive Cardiovascular Care Santa Maria California 93454 Recruiting
FOMAT Medical Research Santa Maria California 93454 Recruiting
Jacksonville Center for Clinical Research Jacksonville Florida 32216 Recruiting
Infinite Clinical Research Miami Florida 33133 Recruiting
Flourish Research Acquisition, LLC dba Flourish Research - North Miami Miami Florida 33138 Recruiting
Amavita Research Services North Miami Beach Florida 33169 Recruiting
DBC Research USA, Corp Pembroke Pines Florida 33029 Recruiting
Clinical Site Partners, LLC dba Flourish Research Winter Park Florida 32789 Recruiting
NMH Clinical Research Unit Chicago Illinois 60611 Recruiting
Northwestern Memorial HealthCare - Arkes Pavilion Chicago Illinois 60611 Recruiting
Northwestern Memorial HealthCare - Feinberg Pavilion Chicago Illinois 60611 Recruiting
Northwestern Memorial HealthCare - Galter Pavilion Chicago Illinois 60611 Recruiting
Northwestern Memorial Hospital Investigational Drug Service (IDS) Chicago Illinois 60611 Recruiting
Northwestern University Evanston Illinois 60208 Recruiting
Chicago Medical Research Hazel Crest Illinois 60429 Recruiting
NexGen Research Fort Wayne Indiana 46804 Recruiting
Reid Physician Associates Richmond Indiana 47374 Recruiting
Ascension Saint Agnes Heart Care Baltimore Maryland 21229 Recruiting
Chesapeake Cardiac Care Bowie Maryland 20715 Recruiting
Flourish Research - Bowie Bowie Maryland 20715 Recruiting
Velocity Clinical Research, Lincoln, Pioneer Heart Institute Lincoln Nebraska 68510 Recruiting
NexGen Research Lima Ohio 45801 Recruiting
Headlands Horizons, LLC dba Headlands Research-Brownsville Brownsville Texas 78526 Recruiting
Valley Regional Medical Center Brownsville Texas 78526 Recruiting
Texas Health Physicians Group Fort Worth Texas 76104 Recruiting
Texas Health Research & Education Institute - Fort Worth Fort Worth Texas 76104 Recruiting
North Dallas Research Associates McKinney Texas 75069 Recruiting
Northwest Houston Heart Center Tomball Texas 77375 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 120 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT06991257, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 23, 2026 · Synced Oct 24, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT06991257 live on ClinicalTrials.gov.

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