A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012)
Public ClinicalTrials.gov record NCT06997497. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Open-label, Multicenter Clinical Study to Evaluate the Safety and Efficacy of MK-1084, Cetuximab, and mFOLFOX6 Versus mFOLFOX6 With or Without Bevacizumab as First-line Treatment of Participants With KRAS G12C-mutant, Locally Advanced Unresectable or Metastatic Colorectal Cancer (KANDLELIT-012)
Study identification
- NCT ID
- NCT06997497
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Merck Sharp & Dohme LLC
- Industry
- Enrollment
- 477 participants
Conditions and interventions
Conditions
Interventions
- 5-Fluorouracil Drug
- Bevacizumab Drug
- Bevacizumab biosimilar Drug
- Calderasib Drug
- Cetuximab Biological
- Leucovorin/levofolinate calcium Drug
- Oxaliplatin Drug
Drug · Biological
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 15, 2025
- Primary completion
- Mar 27, 2029
- Completion
- Oct 26, 2030
- Last update posted
- May 13, 2026
2025 – 2030
United States locations
- U.S. sites
- 22
- U.S. states
- 15
- U.S. cities
- 22
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Los Angeles Hematology Oncology Medical Group ( Site 0084) | Los Angeles | California | 90017 | Recruiting |
| Rocky Mountain Cancer Centers (RMCC) ( Site 8000) | Lone Tree | Colorado | 80124 | Recruiting |
| Florida Cancer Specialists - South ( Site 7002) | Fort Myers | Florida | 33901 | Recruiting |
| Orlando Health Cancer Institute ( Site 0065) | Orlando | Florida | 32806 | Recruiting |
| Florida Cancer Specialists - North ( Site 7001) | St. Petersburg | Florida | 33705 | Recruiting |
| Florida Cancer Specialists - East ( Site 7000) | West Palm Beach | Florida | 33401 | Recruiting |
| University of Iowa ( Site 0074) | Iowa City | Iowa | 52242 | Recruiting |
| University of Kentucky ( Site 0055) | Lexington | Kentucky | 40536 | Recruiting |
| Norton Cancer Institute, Audubon Hospital Campus ( Site 0054) | Louisville | Kentucky | 40217 | Recruiting |
| Greater Baltimore Medical Center ( Site 0068) | Baltimore | Maryland | 21204 | Recruiting |
| Hattiesburg Clinic ( Site 0064) | Hattiesburg | Mississippi | 39401 | Recruiting |
| Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana ( Site 2000) | Billings | Montana | 59102 | Recruiting |
| University Of Nebraska Medical Center ( Site 0078) | Omaha | Nebraska | 68198 | Recruiting |
| Renown Regional Medical Center ( Site 0056) | Reno | Nevada | 89502 | Recruiting |
| John Theurer Cancer Center at Hackensack University Medical Center ( Site 0060) | Hackensack | New Jersey | 07601 | Recruiting |
| Miami Valley Hospital South ( Site 0075) | Centerville | Ohio | 45459 | Recruiting |
| Texas Oncology - DFW ( Site 8002) | Dallas | Texas | 75246 | Recruiting |
| Texas Oncology - Northeast Texas ( Site 8001) | Denison | Texas | 75020 | Recruiting |
| Texas Oncology - San Antonio ( Site 8004) | San Antonio | Texas | 78240 | Recruiting |
| Community Cancer Trials of Utah ( Site 0086) | Ogden | Utah | 84405 | Recruiting |
| University of Virginia ( Site 0080) | Charlottesville | Virginia | 22908 | Recruiting |
| Virginia Cancer Specialists, PC ( Site 0069) | Fairfax | Virginia | 22031 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 158 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06997497, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 13, 2026 · Synced May 21, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06997497 live on ClinicalTrials.gov.