ORION-1: Study of AVZO-023 as a Single Agent and in Combination With AVZO-021, and/or Endocrine Therapy in Advanced Solid Tumors
Public ClinicalTrials.gov record NCT06998407. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2, First-in-human Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of AVZO-023 as a Single Agent, and in Combination With AVZO-021 and/or Endocrine Therapy in Patients With Advanced Solid Tumors
Study identification
- NCT ID
- NCT06998407
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Avenzo Therapeutics, Inc.
- Industry
- Enrollment
- 380 participants
Conditions and interventions
Interventions
- AVZO-021 Drug
- AVZO-023 Drug
- Fulvestrant Drug
- Letrozole Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 19, 2025
- Primary completion
- Jul 31, 2028
- Completion
- Jul 31, 2030
- Last update posted
- May 3, 2026
2025 – 2030
United States locations
- U.S. sites
- 14
- U.S. states
- 9
- U.S. cities
- 13
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Avenzo Therapeutics Recruiting Site | Los Angeles | California | 90025 | Recruiting |
| Avenzo Therapeutics Recruiting Site | Los Angeles | California | 90095 | Recruiting |
| Avenzo Therapeutics Recruiting Site | New Haven | Connecticut | 06519 | Recruiting |
| Avenzo Therapeutics Recruiting Site | Orlando | Florida | 32827 | Recruiting |
| Avenzo Therapeutics Recruiting Site | Sarasota | Florida | 34232 | Recruiting |
| Avenzo Therapeutics Recruiting Site | Boston | Massachusetts | 02215 | Recruiting |
| Avenzo Therapeutics Recruiting Site | New York | New York | 10016 | Recruiting |
| Avenzo Therapeutics Recruiting Site | Cleveland | Ohio | 44106 | Recruiting |
| Avenzo Therapeutics Recruiting Site | Columbus | Ohio | 43221 | Recruiting |
| Avenzo Therapeutics Recruiting Site | Nashville | Tennessee | 37203 | Recruiting |
| Avenzo Therapeutics Recruiting Site | Fort Worth | Texas | 76104 | Recruiting |
| Avenzo Therapeutics Recruiting Site | Houston | Texas | 77030 | Recruiting |
| Avenzo Therapeutics Recruiting Site | San Antonio | Texas | 78229 | Recruiting |
| Avenzo Therapeutics Recruiting Site | Fairfax | Virginia | 22031 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT06998407, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 3, 2026 · Synced May 5, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT06998407 live on ClinicalTrials.gov.