A Phase III Study to Assess the Effect of AZD0780 on LDL-C in Patients With Clinical ASCVD or at Risk for a First ASCVD Event
Public ClinicalTrials.gov record NCT07000123. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase III, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Assess the Effect of AZD0780 on Low-Density Lipoprotein Cholesterol in Patients With Elevated Low Density Lipoprotein Cholesterol and Clinical Atherosclerotic Cardiovascular Disease or at Risk for a First Atherosclerotic Cardiovascular Disease Event
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a study to evaluate the efficacy and safety of AZD0780 in adults with clinical ASCVD or who are at risk for a first ASCVD event and who have elevated LDL-C. AZD0780 is a small molecule that reduces the amount of LDL-C in the blood. Placebo will be used for comparison, and neither the participants nor the Investigators will know who is receiving the AZD0780 medication and who is receiving the placebo until the end of study. The total length of the study for an individual participant will be up to approximately 56 weeks, including a screening period of up to 14 days, treatment with AZD0780 or placebo for 52 weeks, and a safety follow-up period of 10 days.
Study identification
- NCT ID
- NCT07000123
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 3,103 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- May 28, 2025 (Actual)
- Primary completion
- Jan 11, 2027 (Estimated)
- Completion
- Jan 11, 2027 (Estimated)
- Last update posted
- Aug 11, 2026
2025 – 2027
United States locations
- U.S. sites
- 101
- U.S. states
- 26
- U.S. cities
- 95
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Research Site | Huntsville | Alabama | 35801 | — |
| Research Site | Irondale | Alabama | 35210 | — |
| Research Site | Mobile | Alabama | 36608 | — |
| Research Site | Gilbert | Arizona | 85296 | — |
| Research Site | Phoenix | Arizona | 85014 | — |
| Research Site | Sun City West | Arizona | 85375 | — |
| Research Site | Garden Grove | California | 92844 | — |
| Research Site | Gardena | California | 90247 | — |
| Research Site | Lancaster | California | 93534 | — |
| Research Site | Lincoln | California | 95648 | — |
| Research Site | San Diego | California | 92103 | — |
| Research Site | San Diego | California | 92111 | — |
| Research Site | Torrance | California | 90502 | — |
| Research Site | West Hills | California | 91307 | — |
| Research Site | Hamden | Connecticut | 06517 | — |
| Research Site | Boca Raton | Florida | 33434 | — |
| Research Site | Hallandale | Florida | 33009 | — |
| Research Site | Hialeah | Florida | 33012 | — |
| Research Site | Inverness | Florida | 34452 | — |
| Research Site | Jacksonville | Florida | 32216 | — |
| Research Site | Miami | Florida | 33176 | — |
| Research Site | New Port Richey | Florida | 34653 | — |
| Research Site | Orlando | Florida | 32807 | — |
| Research Site | Pembroke Pines | Florida | 33029 | — |
| Research Site | Seminole | Florida | 33777 | — |
| Research Site | Tampa | Florida | 33625 | — |
| Research Site | Atlanta | Georgia | 30328 | — |
| Research Site | Atlanta | Georgia | 30342 | — |
| Research Site | Decatur | Georgia | 30030 | — |
| Research Site | Peachtree Corners | Georgia | 30092 | — |
| Research Site | Chicago | Illinois | 60607 | — |
| Research Site | Winfield | Illinois | 60190 | — |
| Research Site | Evansville | Indiana | 47714 | — |
| Research Site | Evansville | Indiana | 47715 | — |
| Research Site | Indianapolis | Indiana | 46260 | — |
| Research Site | Ames | Iowa | 50010 | — |
| Research Site | El Dorado | Kansas | 67042 | — |
| Research Site | Wichita | Kansas | 67218 | — |
| Research Site | Owensboro | Kentucky | 42301 | — |
| Research Site | Hammond | Louisiana | 70403 | — |
| Research Site | Kenner | Louisiana | 70065 | — |
| Research Site | Lafayette | Louisiana | 70508 | — |
| Research Site | Lake Charles | Louisiana | 70601 | — |
| Research Site | Shreveport | Louisiana | 71105 | — |
| Research Site | Zachary | Louisiana | 70791 | — |
| Research Site | Annapolis | Maryland | 21401 | — |
| Research Site | Baltimore | Maryland | 21229 | — |
| Research Site | Beltsville | Maryland | 20705 | — |
| Research Site | Potomac | Maryland | 20854 | — |
| Research Site | Chesterfield | Missouri | 63005 | — |
| Research Site | Jefferson City | Missouri | 65109 | — |
| Research Site | Kansas City | Missouri | 64131 | — |
| Research Site | Missoula | Montana | 59808 | — |
| Research Site | Buffalo | New York | 14217 | — |
| Research Site | Rochester | New York | 14609 | — |
| Research Site | The Bronx | New York | 10451 | — |
| Research Site | Durham | North Carolina | 27701 | — |
| Research Site | Greensboro | North Carolina | 27408 | — |
| Research Site | Hickory | North Carolina | 28601 | — |
| Research Site | Morganton | North Carolina | 28655 | — |
| Research Site | New Bern | North Carolina | 28562 | — |
| Research Site | Raleigh | North Carolina | 27609 | — |
| Research Site | Rocky Mount | North Carolina | 27804 | — |
| Research Site | Salisbury | North Carolina | 28144 | — |
| Research Site | Statesville | North Carolina | 28625 | — |
| Research Site | Wilmington | North Carolina | 28401 | — |
| Research Site | Fargo | North Dakota | 58104 | — |
| Research Site | Blue Ash | Ohio | 45242 | — |
| Research Site | Columbus | Ohio | 43213 | — |
| Research Site | Columbus | Ohio | 43215 | — |
| Research Site | Lima | Ohio | 45805 | — |
| Research Site | Camp Hill | Pennsylvania | 17011 | — |
| Research Site | Horsham | Pennsylvania | 19044 | — |
| Research Site | Philadelphia | Pennsylvania | 19114 | — |
| Research Site | West Chester | Pennsylvania | 19380 | — |
| Research Site | Anderson | South Carolina | 29621 | — |
| Research Site | Fort Mill | South Carolina | 29707 | — |
| Research Site | Mauldin | South Carolina | 29662 | — |
| Research Site | Mt. Pleasant | South Carolina | 29464 | — |
| Research Site | North Charleston | South Carolina | 29405 | — |
| Research Site | Rapid City | South Dakota | 57701 | — |
| Research Site | Bristol | Tennessee | 37620 | — |
| Research Site | Knoxville | Tennessee | 37849 | — |
| Research Site | Knoxville | Tennessee | 37912 | — |
| Research Site | Knoxville | Tennessee | 37938 | — |
| Research Site | Beaumont | Texas | 77706 | — |
| Research Site | El Paso | Texas | 79902 | — |
| Research Site | Houston | Texas | 77043 | — |
| Research Site | Humble | Texas | 77338 | — |
| Research Site | Irving | Texas | 75061 | — |
| Research Site | Katy | Texas | 77450 | — |
| Research Site | Mesquite | Texas | 75149 | — |
| Research Site | Paris | Texas | 75462 | — |
| Research Site | San Antonio | Texas | 78229 | — |
| Research Site | San Marcos | Texas | 78666 | — |
| Research Site | Sugar Land | Texas | 77478 | — |
| Research Site | Charlottesville | Virginia | 22911 | — |
| Research Site | Hampton | Virginia | 23666 | — |
| Research Site | Norfolk | Virginia | 23504 | — |
| Research Site | Suffolk | Virginia | 23435 | — |
| Research Site | Redmond | Washington | 98052 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 303 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07000123, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 11, 2026 · Synced Oct 24, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07000123 live on ClinicalTrials.gov.