A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)

ClinicalTrials.gov ID: NCT07005128

Public ClinicalTrials.gov record NCT07005128. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 6, 2026, 12:58 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Open Label, Multicenter, Randomized Study of First Line Tarlatamab in Combination With Durvalumab, Carboplatin and Etoposide Versus Durvalumab, Carboplatin and Etoposide in Untreated Extensive Stage Small-Cell Lung Cancer (DeLLphi-312)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The main objective of the study is to compare the efficacy of tarlatamab in combination with durvalumab, carboplatin and etoposide to the combination of durvalumab, carboplatin and etoposide on prolonging overall survival (OS).

Study identification

NCT ID: NCT07005128
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Amgen; Industry
Enrollment: 330 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range: 18 Years to 99 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Aug 17, 2025
Primary completion: Jan 3, 2029
Completion: Jul 14, 2029
Last update posted: Jul 15, 2026

2025 – 2029

United States locations

U.S. sites: 50
U.S. states: 23
U.S. cities: 48

Facility	City	State	ZIP	Site status
Cancer and Blood Specialists of Arizona	Casa Grande	Arizona	85222	Recruiting
City of Hope Cancer Center Phoenix	Goodyear	Arizona	85338	Recruiting
Genesis Cancer Center	Hot Springs	Arkansas	71913	Recruiting
Saint Bernards Medical Center	Jonesboro	Arkansas	72401	Recruiting
Providence Saint Jude Medical Center	Fullerton	California	92835	Recruiting
Translational Research in Oncology US Inc, Trio Central Pharmacy	Los Angeles	California	90095	Recruiting
University of California Los Angeles	Santa Monica	California	90404	Recruiting
Presbyterian Intercommunity Hospital Health Whitter Hospital	Whittier	California	90602	Recruiting
Colorado West Healthcare System dba Grand Valley Oncology	Grand Junction	Colorado	81505	Recruiting
Hartford HealthCare Cancer Institute at The Hospital of Central Connecticut	New Britain	Connecticut	06053	Recruiting
Yale New Haven Hospital	New Haven	Connecticut	06510	Recruiting
Eastern Connecticut Hematology and Oncology Associates	Norwich	Connecticut	06360	Recruiting
Florida Oncology and Hematology	Fort Myers	Florida	33912	Recruiting
Cancer Specialists of North Florida - Southpoint	Jacksonville	Florida	32256	Recruiting
Orlando Health Cancer Institute	Kissimmee	Florida	34744	Recruiting
Central Georgia Cancer Care PC	Macon	Georgia	31210	Recruiting
City of Hope Atlanta	Newnan	Georgia	30265	Recruiting
University of Illinois Chicago	Chicago	Illinois	60612	Recruiting
Cancer Care Specialists of Illinois	Decatur	Illinois	62526	Recruiting
Midwestern Regional Medical Center dba City of Hope Chicago	Rockford	Illinois	61108	Recruiting
Indiana University Melvin and Bren Simon Cancer Center	Indianapolis	Indiana	46202	Recruiting
Hematology Oncology of Indiana	Indianapolis	Indiana	46260	Recruiting
Cancer Center of Kansas, Heritage Plaza Medical Building	Wichita	Kansas	67214	Recruiting
New England Cancer Specialists	Westbrook	Maine	04092	Recruiting
Dana Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Minnesota Oncology Hematology PA	Edina	Minnesota	55435	Recruiting
Allina Health System dba Allina Health Cancer Institute	Minneapolis	Minnesota	55407	Recruiting
Mayo Clinic	Rochester	Minnesota	55905	Recruiting
Hattiesburg Clinic Hematology/Oncology	Hattiesburg	Mississippi	39401	Recruiting
Cancer Partners of Nebraska	Lincoln	Nebraska	68516	Recruiting
Nebraska Cancer Specialists	Omaha	Nebraska	68130	Recruiting
New York Oncology Hematology PC	Albany	New York	12206	Recruiting
Hematology Oncology Association of Central New York	East Syracuse	New York	13057	Recruiting
New York Cancer and Blood Specialists	Shirley	New York	11967	Recruiting
Oncology Hematology Care, Inc	Cincinnati	Ohio	45242	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
Willamette Valley Cancer Institute and Research Center - Eugene	Eugene	Oregon	97401	Recruiting
Kaiser Permanente Medical Center	Portland	Oregon	97227	Recruiting
Baptist Cancer Center	Memphis	Tennessee	38120	Recruiting
United States Oncology Regulatory Affairs Corporate Office	Nashville	Tennessee	37203	Recruiting
Texas Oncology - Dallas Fort Worth	Dallas	Texas	75246	Recruiting
Oncology Consultants	Houston	Texas	77030	Recruiting
US Oncology Research Investigational Products Center	Irving	Texas	75063	Recruiting
University of Texas Health Science Center at Tyler	Tyler	Texas	75701	Recruiting
Texas Oncology Northeast Texas	Tyler	Texas	75702	Recruiting
Virginia Cancer Specialists PC	Fairfax	Virginia	22031	Recruiting
Virginia Oncology Associates	Norfolk	Virginia	23502	Recruiting
Swedish Cancer Institute Medical Oncology	Seattle	Washington	98104	Recruiting
Northwest Medical Specialties, PLLC	Tacoma	Washington	98405	Recruiting
West Virginia University Health Sciences Center	Morgantown	West Virginia	26506	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 114 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07005128, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Jul 15, 2026 · Synced Sep 6, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07005128 live on ClinicalTrials.gov.

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