A Study Comparing Tarlatamab, Durvalumab, Carboplatin, and Etoposide Versus Durvalumab, Carboplatin, and Etoposide in First-line Extensive Stage Small-Cell Lung Cancer (ES-SCLC)
Public ClinicalTrials.gov record NCT07005128. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Open Label, Multicenter, Randomized Study of First Line Tarlatamab in Combination With Durvalumab, Carboplatin and Etoposide Versus Durvalumab, Carboplatin and Etoposide in Untreated Extensive Stage Small-Cell Lung Cancer (DeLLphi-312)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The main objective of the study is to compare the efficacy of tarlatamab in combination with durvalumab, carboplatin and etoposide to the combination of durvalumab, carboplatin and etoposide on prolonging overall survival (OS).
Study identification
- NCT ID
- NCT07005128
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 350 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 99 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Aug 18, 2025 (Actual)
- Primary completion
- Jan 4, 2029 (Estimated)
- Completion
- Aug 15, 2029 (Estimated)
- Last update posted
- Sep 8, 2026
2025 – 2029
United States locations
- U.S. sites
- 50
- U.S. states
- 23
- U.S. cities
- 48
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Cancer and Blood Specialists of Arizona | Casa Grande | Arizona | 85222 | — |
| City of Hope Cancer Center Phoenix | Goodyear | Arizona | 85338 | — |
| Genesis Cancer Center | Hot Springs | Arkansas | 71913 | — |
| Saint Bernards Medical Center | Jonesboro | Arkansas | 72401 | — |
| Providence Saint Jude Medical Center | Fullerton | California | 92835 | — |
| Translational Research in Oncology US Inc, Trio Central Pharmacy | Los Angeles | California | 90095 | — |
| University of California Los Angeles | Santa Monica | California | 90404 | — |
| Presbyterian Intercommunity Hospital Health Whitter Hospital | Whittier | California | 90602 | — |
| Colorado West Healthcare System dba Grand Valley Oncology | Grand Junction | Colorado | 81505 | — |
| Hartford HealthCare Cancer Institute at The Hospital of Central Connecticut | New Britain | Connecticut | 06053 | — |
| Yale New Haven Hospital | New Haven | Connecticut | 06510 | — |
| Eastern Connecticut Hematology and Oncology Associates | Norwich | Connecticut | 06360 | — |
| Florida Oncology and Hematology | Fort Myers | Florida | 33912 | — |
| Cancer Specialists of North Florida - Southpoint | Jacksonville | Florida | 32256 | — |
| Orlando Health Cancer Institute | Kissimmee | Florida | 34744 | — |
| Central Georgia Cancer Care PC | Macon | Georgia | 31210 | — |
| City of Hope Atlanta | Newnan | Georgia | 30265 | — |
| University of Illinois Chicago | Chicago | Illinois | 60612 | — |
| Cancer Care Specialists of Illinois | Decatur | Illinois | 62526 | — |
| Midwestern Regional Medical Center dba City of Hope Chicago | Rockford | Illinois | 61108 | — |
| Indiana University Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | — |
| Hematology Oncology of Indiana | Indianapolis | Indiana | 46260 | — |
| Cancer Center of Kansas, Heritage Plaza Medical Building | Wichita | Kansas | 67214 | — |
| New England Cancer Specialists | Westbrook | Maine | 04092 | — |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02215 | — |
| Minnesota Oncology Hematology PA | Edina | Minnesota | 55435 | — |
| Allina Health System dba Allina Health Cancer Institute | Minneapolis | Minnesota | 55407 | — |
| Mayo Clinic | Rochester | Minnesota | 55905 | — |
| Hattiesburg Clinic Hematology/Oncology | Hattiesburg | Mississippi | 39401 | — |
| Cancer Partners of Nebraska | Lincoln | Nebraska | 68516 | — |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | — |
| New York Oncology Hematology PC | Albany | New York | 12206 | — |
| Hematology Oncology Association of Central New York | East Syracuse | New York | 13057 | — |
| New York Cancer and Blood Specialists | Shirley | New York | 11967 | — |
| Oncology Hematology Care, Inc | Cincinnati | Ohio | 45242 | — |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | — |
| Willamette Valley Cancer Institute and Research Center - Eugene | Eugene | Oregon | 97401 | — |
| Kaiser Permanente Medical Center | Portland | Oregon | 97227 | — |
| Baptist Cancer Center | Memphis | Tennessee | 38120 | — |
| United States Oncology Regulatory Affairs Corporate Office | Nashville | Tennessee | 37203 | — |
| Texas Oncology - Dallas Fort Worth | Dallas | Texas | 75246 | — |
| Oncology Consultants | Houston | Texas | 77030 | — |
| US Oncology Research Investigational Products Center | Irving | Texas | 75063 | — |
| University of Texas Health Science Center at Tyler | Tyler | Texas | 75701 | — |
| Texas Oncology - Northeast Texas | Tyler | Texas | 75702 | — |
| Virginia Cancer Specialists PC | Fairfax | Virginia | 22031 | — |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | — |
| Swedish Cancer Institute Medical Oncology | Seattle | Washington | 98104 | — |
| Northwest Medical Specialties, PLLC | Tacoma | Washington | 98405 | — |
| West Virginia University Health Sciences Center | Morgantown | West Virginia | 26506 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 114 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07005128, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 8, 2026 · Synced Oct 21, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07005128 live on ClinicalTrials.gov.