ASPEN-09-03: A Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Metastatic HER2-Positive Breast Cancer
Public ClinicalTrials.gov record NCT07007559. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
Protocol ASPEN-09-03: A Single-arm Phase 2 Multicenter Study of Evorpacept in Combination With Trastuzumab and Chemotherapy in Participants With Metastatic HER2-Positive Breast Cancer, a Substudy Under Master Protocol ASPEN-09: A Phase 1b/2, Multicenter, Multi Arm Study of Evorpacept in Combination With Anti-cancer Therapies in Advanced / Metastatic Malignancies
Study identification
- NCT ID
- NCT07007559
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- ALX Oncology Inc.
- Industry
- Enrollment
- 120 participants
Conditions and interventions
Conditions
Interventions
- Capecitabine Drug
- Eribulin Drug
- Evorpacept (ALX148) Drug
- Gemcitabine Drug
- Paclitaxel Drug
- Trastuzumab Drug
- Vinorelbine Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 9, 2025
- Primary completion
- Nov 30, 2027
- Completion
- Nov 30, 2028
- Last update posted
- Apr 12, 2026
2025 – 2028
United States locations
- U.S. sites
- 15
- U.S. states
- 12
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| The University of Arizona Cancer Center - North Campus | Tucson | Arizona | 85719 | Recruiting |
| City of Hope | Duarte | California | 91010 | Recruiting |
| Saint Joseph Hospital - Cancer Centers of Colorado | Denver | Colorado | 80218 | Recruiting |
| Lutheran Hospital - Cancer Centers of Colorado | Golden | Colorado | 80401 | Recruiting |
| Saint Mary's Regional Hospital - Cancer Centers of Colorado | Grand Junction | Colorado | 81501 | Recruiting |
| The George Washington Medical facility Associates | Washington D.C. | District of Columbia | 20037 | Recruiting |
| City of Hope Chicago | Zion | Illinois | 60099 | Recruiting |
| University of Michigan Rogel Cancer Center | Ann Arbor | Michigan | 48109 | Recruiting |
| HealthPartners Frauenshuh Cancer Center | Saint Louis Park | Minnesota | 55426 | Recruiting |
| St. Vincent Regional Hospital - Cancer Centers of Montana | Billings | Montana | 59102 | Recruiting |
| Oncology Hematology West, Pc Dba Nebraska Cancer Specialists | Omaha | Nebraska | 68130 | Recruiting |
| Gabrail Cancer Center | Canton | Ohio | 44718 | Recruiting |
| University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| The University of Texas M.D. Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07007559, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 12, 2026 · Synced May 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07007559 live on ClinicalTrials.gov.