Neoadjuvant Darovasertib in Primary Uveal Melanoma
Public ClinicalTrials.gov record NCT07015190. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Phase 3, Open-label Study of Neoadjuvant Darovasertib in Subjects With Primary Non-metastatic Uveal Melanoma (OptimUM-10)
Study identification
- NCT ID
- NCT07015190
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- IDEAYA Biosciences
- Industry
- Enrollment
- 520 participants
Conditions and interventions
Conditions
Interventions
- Darovasertib Drug
- Primary Local Therapy Procedure
Drug · Procedure
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jan 24, 2026
- Primary completion
- Sep 30, 2030
- Completion
- Feb 28, 2031
- Last update posted
- May 5, 2026
2026 – 2031
United States locations
- U.S. sites
- 35
- U.S. states
- 17
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Mayo Clinic Scottsdale - PPDS | Scottsdale | Arizona | 85259 | Recruiting |
| UCSD Moores Cancer Center | La Jolla | California | 92093 | Not yet recruiting |
| Jules Stein Eye Institute | Los Angeles | California | 90024 | Not yet recruiting |
| USC Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | Not yet recruiting |
| University of California Irvine Medical Center | Orange | California | 92868 | Not yet recruiting |
| Stanford Comprehensive Cancer Center | Palo Alto | California | 94304 | Recruiting |
| Kaiser Permanente-Riverside Medical Center | Riverside | California | 92505-3043 | Recruiting |
| UCSF Wayne and Gladys Valley Center for Vision | San Francisco | California | 94143 | Not yet recruiting |
| University of Colorado Hospital | Aurora | Colorado | 80045 | Recruiting |
| The Melanoma and Skin Cancer Institute | Englewood | Colorado | 80113-2791 | Not yet recruiting |
| Mayo Clinic Jacksonville | Jacksonville | Florida | 32224 | Recruiting |
| USF Health Eye Institute | Tampa | Florida | 33612-6601 | Not yet recruiting |
| Moffit Cancer Center | Tampa | Florida | 33612 | Not yet recruiting |
| Wilmer Eye Institute | Baltimore | Maryland | 21287-0005 | Recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Not yet recruiting |
| W Kellogg Eye Center | Ann Arbor | Michigan | 48105 | Not yet recruiting |
| The Cancer and Hematology Centers of West Michigan (CHCWM) | Grand Rapids | Michigan | 49503 | Recruiting |
| Mayo Clinic - PPDS | Rochester | Minnesota | 55905 | Recruiting |
| TIERING Percentiles | Omaha | Nebraska | 68105 | Not yet recruiting |
| Herbert Irving Comprehensive Cancer Center | New York | New York | 10032 | Recruiting |
| Memorial Sloan Kettering Cancer Center - 1275 York Ave | New York | New York | 10065-6635 | Not yet recruiting |
| Northwell Health Cancer Institute | New York | New York | 11042 | Not yet recruiting |
| Cole Eye Institute-9500 Euclid Ave | Cleveland | Ohio | 44195 | Not yet recruiting |
| Ohio State Eye and Ear Institute | Columbus | Ohio | 43212 | Not yet recruiting |
| Retina Consultants of Oklahoma | Oklahoma City | Oklahoma | 73112 | Not yet recruiting |
| Jefferson Health Honickman Center | Philadelphia | Pennsylvania | 19107 | Not yet recruiting |
| UPMC Hillman Cancer Center | Pittsburgh | Pennsylvania | 15232 | Not yet recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Vanderbilt Eye Institute | Nashville | Tennessee | 37232 | Not yet recruiting |
| Austin Retina Associates - Central | Austin | Texas | 78705 | Recruiting |
| Texas Retina Associates - Dallas | Dallas | Texas | 75231 | Recruiting |
| University of Texas Southwestern Medical Center-5323 Harry Hines Blvd | Dallas | Texas | 75390-9057 | Recruiting |
| Retina Consultants of Texas - (Houston) | Houston | Texas | 77030-2727 | Not yet recruiting |
| Augusta Health, Center for Cancer and Blood Disorders | Fishersville | Virginia | 22939 | Not yet recruiting |
| University of Wisconsin Health | Madison | Wisconsin | 53705-3644 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 59 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07015190, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 5, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07015190 live on ClinicalTrials.gov.