REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults
Public ClinicalTrials.gov record NCT07015905. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Randomized, Open-Label, Study to Evaluate REGN7508, A Factor XI Monoclonal Antibody, Versus Apixaban and Enoxaparin for Prophylaxis of Venous Thromboembolism After Elective Total Knee Arthroplasty (ROXI-APEX)
Study identification
- NCT ID
- NCT07015905
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Regeneron Pharmaceuticals
- Industry
- Enrollment
- 2,000 participants
Conditions and interventions
Conditions
Interventions
- Apixaban Drug
- Enoxaparin Drug
- Placebo Drug
- REGN7508 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 24, 2025
- Primary completion
- Feb 19, 2027
- Completion
- May 11, 2027
- Last update posted
- May 5, 2026
2025 – 2027
United States locations
- U.S. sites
- 19
- U.S. states
- 11
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Shoals Medical Trials, Inc. | Sheffield | Alabama | 35660 | Recruiting |
| CARI Clinical Trials | Riverside | California | 92504 | Recruiting |
| Denver Metro Orthopedics, P.C. Englewood Location | Englewood | Colorado | 80113 | Recruiting |
| Delray Physician Care Center | Delray Beach | Florida | 33445 | Recruiting |
| Bioresearch Partner | Miami | Florida | 33175 | Recruiting |
| Sacred Heart Health System Inc | Pensacola | Florida | 32504 | Recruiting |
| Gulfcoast Research Institute | Sarasota | Florida | 34232 | Recruiting |
| Phoenix Clinical Research | Tamarac | Florida | 33321 | Recruiting |
| Sinai Hospital of Baltimore, Inc. | Baltimore | Maryland | 21215 | Recruiting |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | Recruiting |
| Curalta Clinical Trials | Westwood | New Jersey | 07675 | Recruiting |
| Duke University Health System (Duke Health), Duke University Hospital | Durham | North Carolina | 27710 | Recruiting |
| Keystone Clinical Studies LLC, dba Flourish Research | Plymouth Meeting | Pennsylvania | 19462 | Recruiting |
| HD Research - First Surgical Hospital | Bellaire | Texas | 77401 | Recruiting |
| University of Texas (UT); Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| NextStage Clinical Research, All American Orthopedics and Sports Medicine | Houston | Texas | 77058 | Recruiting |
| Futuro Clinical Trials | McAllen | Texas | 78501 | Recruiting |
| Flourish Research - San Antonio (Formerly Clinical Trials of Texas) | San Antonio | Texas | 78229 | Recruiting |
| DRx Clinical Research, LLC | St. George | Utah | 84770 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 25 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07015905, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 5, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07015905 live on ClinicalTrials.gov.