REGN7508 Versus Apixaban and Enoxaparin for Thromboprophylaxis After Total Knee Arthroplasty in Adults
Public ClinicalTrials.gov record NCT07015905. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Randomized, Open-Label, Study to Evaluate REGN7508, A Factor XI Monoclonal Antibody, Versus Apixaban and Enoxaparin for Prophylaxis of Venous Thromboembolism After Elective Total Knee Arthroplasty (ROXI-APEX)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is researching an experimental drug called REGN7508 (called "study drug"). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing Venous Thromboembolism (VTE) and other related diseases after total knee replacement surgery. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)
Study identification
- NCT ID
- NCT07015905
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,000 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 24, 2025
- Primary completion
- Feb 19, 2027
- Completion
- May 11, 2027
- Last update posted
- Jul 12, 2026
2025 – 2027
United States locations
- U.S. sites
- 20
- U.S. states
- 11
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Shoals Medical Trials, Inc. | Sheffield | Alabama | 35660 | Recruiting |
| CARI Clinical Trials | Riverside | California | 92504 | Recruiting |
| Denver Metro Orthopedics, P.C. Englewood Location | Englewood | Colorado | 80113 | Recruiting |
| Delray Physician Care Center | Delray Beach | Florida | 33445 | Recruiting |
| Bioresearch Partner | Miami | Florida | 33175 | Recruiting |
| Sacred Heart Health System Inc | Pensacola | Florida | 32504 | Recruiting |
| Gulfcoast Research Institute | Sarasota | Florida | 34232 | Recruiting |
| Phoenix Clinical Research | Tamarac | Florida | 33321 | Recruiting |
| Sinai Hospital of Baltimore, Inc. | Baltimore | Maryland | 21215 | Recruiting |
| Brigham and Women's Hospital | Boston | Massachusetts | 02115 | Recruiting |
| Curalta Clinical Trials | Westwood | New Jersey | 07675 | Recruiting |
| Duke University Health System (Duke Health), Duke University Hospital | Durham | North Carolina | 27710 | Recruiting |
| Keystone Clinical Studies LLC, dba Flourish Research | Plymouth Meeting | Pennsylvania | 19462 | Recruiting |
| HD Research - First Surgical Hospital | Bellaire | Texas | 77401 | Recruiting |
| University of Texas (UT); Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| NextStage Clinical Research, All American Orthopedics and Sports Medicine | Houston | Texas | 77058 | Recruiting |
| Futuro Clinical Trials | McAllen | Texas | 78501 | Recruiting |
| Flourish Research - San Antonio (Formerly Clinical Trials of Texas) | San Antonio | Texas | 78229 | Recruiting |
| DRx Clinical Research, LLC; South Texas Bone and Joint Institute | San Antonio | Texas | 78249 | Recruiting |
| DRx Clinical Research, LLC | St. George | Utah | 84770 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 26 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07015905, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 12, 2026 · Synced Sep 7, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07015905 live on ClinicalTrials.gov.