A Long-Term Study to Learn About The Study Medicine Called Ritlecitinib in Children With Severe Alopecia Areata.
Public ClinicalTrials.gov record NCT07029828. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A LONG-TERM, DOUBLE-BLIND EXTENSION STUDY TO INVESTIGATE THE SAFETY AND EFFICACY OF RITLECITINIB IN PARTICIPANTS WITH SEVERE ALOPECIA AREATA WHO PREVIOUSLY COMPLETED STUDIES B7981027 OR B7981031
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this clinical trial is to learn about long-term safety and long-term effects of the study medicine (called ritlecitinib) for the potential treatment of severe alopecia areata, a condition that causes hair loss. This study is seeking participants who have: * previously completed one of Pfizer's pediatric studies for Alopecia Areata (B7981027 or B7981031). * at least 50% scalp hair loss due to alopecia areata (for participants enrolling from the study B7981031). * received varicella vaccination (2 doses) or have been infected by varicella zoster virus before based on blood test reports. All participants in this study will receive the study medicine (ritlecitinib). Participants who received ritlecitinib higher or lower doses in the parent Study B7981027 will continue receiving the same ritlecitinib dose in this trial. Participants who received placebo in the parent Study B7981027 and all participants from parent Study B7981031 will receive either higher or lower dose of ritlecitinib in this trial. The study medicine is a capsule that is taken by mouth. It is taken 1 time each day at home. The study will help see if ritlecitinib is safe and effective. Participants will take part in this study for a duration of up to 3 years (36 months). During this time, they will have 17 study visits at the study clinic. The study team will also call participants once a month over the phone.
Study identification
- NCT ID
- NCT07029828
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 140 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 6 Years to 14 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 9, 2025
- Primary completion
- Jun 25, 2030
- Completion
- Jun 25, 2030
- Last update posted
- Apr 27, 2026
2025 – 2030
United States locations
- U.S. sites
- 18
- U.S. states
- 12
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| California Dermatology & Clinical Research Institute | Encinitas | California | 92024 | Recruiting |
| Pediatric Skin Research | Miami | Florida | 33156 | Recruiting |
| D&H Tamarac Research Center | Tamarac | Florida | 33321 | Not yet recruiting |
| Dawes Fretzin Clinical Research Group, LLC | Indianapolis | Indiana | 46250 | Recruiting |
| Kindred Hair and Skin Center | Marriottsville | Maryland | 21104 | Not yet recruiting |
| Michigan Dermatology Institute | Waterford | Michigan | 48328 | Not yet recruiting |
| Ear, Nose & Throat Consultants, LLC | Omaha | Nebraska | 68144 | Recruiting |
| Skin Specialists, PC dba Schlessinger MD | Omaha | Nebraska | 68144 | Recruiting |
| Complete Behavior Health (Dr. Brittany Marshall, Licensed Psychologist) | Papillion | Nebraska | 68046 | Recruiting |
| University of New Mexico Health Sciences Center | Albuquerque | New Mexico | 87102 | Recruiting |
| University of New Mexico-IDS Pharmacy | Albuquerque | New Mexico | 87106 | Recruiting |
| Regents of the University of New Mexico | Albuquerque | New Mexico | 87131 | Recruiting |
| Equity Medical, LLC | The Bronx | New York | 10455 | Not yet recruiting |
| Northwest Dermatology Institute | Portland | Oregon | 97210 | Recruiting |
| Penn State Health Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | Not yet recruiting |
| Medical University of South Carolina Department of Dermatology and Dermatologic Surgery | Charleston | South Carolina | 29425 | Not yet recruiting |
| 3A Research | El Paso | Texas | 79902 | Recruiting |
| Texas Dermatology and Laser Specialists | San Antonio | Texas | 78218 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 23 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07029828, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 27, 2026 · Synced Sep 10, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07029828 live on ClinicalTrials.gov.