AVENTINE-1: Study of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors (AVZO-1418-1001)

ClinicalTrials.gov ID: NCT07038343

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ClinicalTrials.gov public records Last synced Nov 12, 2026, 8:34 PM EST

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Official title

A Phase 1/2, First-in-human Study to Assess the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics, and Antitumor Activity of AVZO-1418 as a Single Agent and in Combination Therapy in Patients With Locally Advanced or Metastatic Solid Tumors

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study, the first clinical trial of AVZO-1418, aims to determine the safety, tolerability, pharmacokinetics, pharmacodynamics, maximum tolerated dose, and antitumor activity of AVZO-1418 when administered intravenously as a monotherapy and potentially in combination therapy to patients with locally advanced or metastatic epithelial solid tumors.

Study identification

NCT ID: NCT07038343
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1, Phase 2
Lead sponsor: Avenzo Therapeutics, Inc.; Industry
Enrollment: 480 participants

Conditions and interventions

Conditions

Interventions

Drug

Eligibility (public fields only)

Age range: 18 Years to 75 Years
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jun 4, 2025 (Actual)
Primary completion: Jun 2030 (Estimated)
Completion: Dec 2030 (Estimated)
Last update posted: Oct 16, 2026

2025 – 2030

United States locations

U.S. sites: 19
U.S. states: 14
U.S. cities: 18

Facility	City	State	ZIP	Site status
Avenzo Therapeutics Recruiting Site	Gilbert	Arizona	85234	Recruiting
Avenzo Therapeutics Recruiting Site	Los Angeles	California	90048	Recruiting
Avenzo Therapeutics Recruiting Site	Los Angeles	California	90095	Recruiting
Avenzo Therapeutics Recruiting Site	Denver	Colorado	80218	Recruiting
Avenzo Therapeutics Recruiting Site	New Haven	Connecticut	06510	Recruiting
Avenzo Therapeutics Recruiting Site	Washington D.C.	District of Columbia	20007	Recruiting
Avenzo Therapeutics Recruiting Site	Orlando	Florida	32827	Recruiting
Avenzo Therapeutics Recruiting Site	Sarasota	Florida	34232	Recruiting
Avenzo Therapeutics Recruiting Site	Tampa	Florida	33612	Recruiting
Avenzo Therapeutics Recruiting Site	Atlanta	Georgia	30322	Recruiting
Avenzo Therapeutics Recruiting Site	Boston	Massachusetts	02215	Recruiting
Avenzo Therapeutics Recruiting Site	New York	New York	10029	Recruiting
Avenzo Therapeutics Recruiting Site	Philadelphia	Pennsylvania	19107	Recruiting
Avenzo Therapeutics Recruiting Site	Dallas	Texas	75039	Recruiting
Avenzo Therapeutics Recruiting Site	Houston	Texas	77054	Recruiting
Avenzo Therapeutics Recruiting Site	San Antonio	Texas	78229	Recruiting
Avenzo Therapeutics Recruiting Site	West Valley City	Utah	84119	Recruiting
Avenzo Therapeutics Recruiting Site	Fairfax	Virginia	22031	Recruiting
Avenzo Therapeutics Recruiting Site	Seattle	Washington	98109	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07038343, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 16, 2026 · Synced Nov 12, 2026