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Recruiting Phase 2 Interventional

Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System

ClinicalTrials.gov ID: NCT07042295

Public ClinicalTrials.gov record NCT07042295. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 18, 2026, 2:38 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Phase II Study of Amivantamab (JNJ-61186372) and Hyaluronidase (rHuPH20) Versus Cetuximab in Immunocompromised Participants With Recurrent Inoperable or Metastatic Cutaneous Squamous Cell Carcinoma

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This phase II trial compares the effect of amivantamab and hyaluronidase to cetuximab for the treatment of skin (cutaneous) squamous cell carcinoma that has come back after a period of improvement and has not spread to other parts of the body (locally recurrent) or that has spread from where it first started (primary site) to other places in the body (metastatic). Amivantamab is a monoclonal antibody that may interfere with the ability of tumor cells to grow and spread. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens). Hyaluronidase is an endoglycosidase. It helps to keep amivantamab in the body longer, so that the medications will have a greater effect. Cetuximab is in a class of medications called monoclonal antibodies. It binds to a protein called EGFR, which is found on some types of cancer cells. This may help keep cancer cells from growing. Giving amivantamab and hyaluronidase may be as effective as cetuximab for the treatment of locally recurrent or metastatic cutaneous squamous cell carcinoma.

Study identification

NCT ID
NCT07042295
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 2
Enrollment
86 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Mar 23, 2026 (Actual)
Primary completion
Feb 28, 2029 (Estimated)
Completion
Feb 28, 2029 (Estimated)
Last update posted
Oct 15, 2026

2026 – 2029

United States locations

U.S. sites
55
U.S. states
19
U.S. cities
51
Facility City State ZIP Site status
University of Alabama at Birmingham Cancer Center Birmingham Alabama 35233 Recruiting
Banner MD Anderson Cancer Center Gilbert Arizona 85234 Recruiting
UC San Diego Moores Cancer Center La Jolla California 92093 Recruiting
The Angeles Clinic and Research Institute - West Los Angeles Office Los Angeles California 90025 Recruiting
USC / Norris Comprehensive Cancer Center Los Angeles California 90033 Recruiting
UCHealth University of Colorado Hospital Aurora Colorado 80045 Recruiting
Yale University New Haven Connecticut 06520 Recruiting
Smilow Cancer Hospital Care Center-Trumbull Trumbull Connecticut 06611 Recruiting
Smilow Cancer Hospital Care Center - Waterford Waterford Connecticut 06385 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Gables Coral Gables Florida 33146 Recruiting
UM Sylvester Comprehensive Cancer Center at Coral Springs Coral Springs Florida 33065 Recruiting
UM Sylvester Comprehensive Cancer Center at Deerfield Beach Deerfield Beach Florida 33442 Recruiting
UM Sylvester Comprehensive Cancer Center at Doral Doral Florida 33166 Recruiting
University of Miami Miller School of Medicine-Sylvester Cancer Center Miami Florida 33136 Recruiting
UM Sylvester Comprehensive Cancer Center at Kendall Miami Florida 33176 Recruiting
University of Miami Sylvester Comprehensive Cancer Center at Sole Mia North Miami Florida 33181 Recruiting
UM Sylvester Comprehensive Cancer Center at Plantation Plantation Florida 33324 Recruiting
Emory University Hospital Midtown Atlanta Georgia 30308 Recruiting
Emory University Hospital/Winship Cancer Institute Atlanta Georgia 30322 Recruiting
University of Chicago Comprehensive Cancer Center Chicago Illinois 60637 Recruiting
Carle at The Riverfront Danville Illinois 61832 Recruiting
Carle Physician Group-Effingham Effingham Illinois 62401 Recruiting
Ingalls Memorial Hospital Harvey Illinois 60426 Recruiting
Carle Physician Group-Mattoon/Charleston Mattoon Illinois 61938 Recruiting
UC Comprehensive Cancer Center at Silver Cross New Lenox Illinois 60451 Recruiting
Carle BroMenn Medical Center Normal Illinois 61761 Recruiting
Carle Cancer Institute Normal Normal Illinois 61761 Recruiting
University of Chicago Medicine-Orland Park Orland Park Illinois 60462 Recruiting
Carle Cancer Center Urbana Illinois 61801 Recruiting
UChicago Medicine Northwest Indiana Crown Point Indiana 46307 Recruiting
University of Michigan Rogel Cancer Center Ann Arbor Michigan 48109 Recruiting
Henry Ford Hospital Detroit Michigan 48202 Recruiting
Memorial Sloan Kettering Basking Ridge Basking Ridge New Jersey 07920 Recruiting
Memorial Sloan Kettering Monmouth Middletown New Jersey 07748 Recruiting
Memorial Sloan Kettering Bergen Montvale New Jersey 07645 Recruiting
Memorial Sloan Kettering Commack Commack New York 11725 Recruiting
Memorial Sloan Kettering Westchester Harrison New York 10604 Recruiting
Memorial Sloan Kettering Cancer Center New York New York 10065 Recruiting
Memorial Sloan Kettering Nassau Uniondale New York 11553 Recruiting
Duke University Medical Center Durham North Carolina 27710 Recruiting
UH Seidman Cancer Center at UH Avon Health Center Avon Ohio 44011 Recruiting
UHHS-Chagrin Highlands Medical Center Beachwood Ohio 44122 Recruiting
University of Cincinnati Cancer Center-UC Medical Center Cincinnati Ohio 45219 Recruiting
Case Western Reserve University Cleveland Ohio 44106 Recruiting
University of Cincinnati Cancer Center-West Chester West Chester Ohio 45069 Recruiting
University of Oklahoma Health Sciences Center Oklahoma City Oklahoma 73104 Recruiting
Penn State Milton S Hershey Medical Center Hershey Pennsylvania 17033-0850 Recruiting
UPMC Hillman Cancer Center Pittsburgh Pennsylvania 15232 Recruiting
UT MD Anderson Cancer Center Houston Texas 77030 Recruiting
Huntsman Cancer Institute/University of Utah Salt Lake City Utah 84112 Recruiting
Froedtert Menomonee Falls Hospital Menomonee Falls Wisconsin 53051 Recruiting
Medical College of Wisconsin Milwaukee Wisconsin 53226 Recruiting
Froedtert and MCW Moorland Reserve Health Center New Berlin Wisconsin 53151 Recruiting
Drexel Town Square Health Center Oak Creek Wisconsin 53154 Recruiting
Froedtert West Bend Hospital/Kraemer Cancer Center West Bend Wisconsin 53095 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07042295, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 15, 2026 · Synced Oct 18, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07042295 live on ClinicalTrials.gov.

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