TRITON-CM: A Study to Evaluate Nucresiran in Patients With Transthyretin Amyloidosis With Cardiomyopathy
Public ClinicalTrials.gov record NCT07052903. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
TRITON-CM: A Phase 3 Global, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Nucresiran in Patients With Transthyretin-Mediated Amyloidosis With Cardiomyopathy (ATTR Amyloidosis With Cardiomyopathy)
Study identification
- NCT ID
- NCT07052903
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Alnylam Pharmaceuticals
- Industry
- Enrollment
- 1,250 participants
Conditions and interventions
Interventions
- Nucresiran Drug
- Sterile Normal Saline (0.9% NaCl) Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 85 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jul 1, 2025
- Primary completion
- May 27, 2030
- Completion
- Nov 29, 2032
- Last update posted
- May 13, 2026
2025 – 2032
United States locations
- U.S. sites
- 39
- U.S. states
- 23
- U.S. cities
- 35
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clinical Trial Site | La Jolla | California | 92037 | Recruiting |
| Clinical Trial Site | Stanford | California | 94305 | Recruiting |
| Clinical Trial Site | Norwich | Connecticut | 06360 | Recruiting |
| Clinical Trial Site | Washington D.C. | District of Columbia | 20010 | Recruiting |
| Clinical Trial Site | Brandon | Florida | 33511 | Recruiting |
| Clinical Trial Site | Miami | Florida | 33125 | Recruiting |
| Clinical Trial Site | Atlanta | Georgia | 30309 | Recruiting |
| Clinical Trial Site | Gainesville | Georgia | 30501 | Recruiting |
| Clinical Trial Site | Tucker | Georgia | 30084 | Recruiting |
| Clinical Trial Site | Evanston | Illinois | 60201 | Recruiting |
| Clinical Trial Site | Indianapolis | Indiana | 46202 | Recruiting |
| Clinical Trial Site | Indianapolis | Indiana | 46260 | Recruiting |
| Clinical Trial Site | Kansas City | Kansas | 66160 | Recruiting |
| Clinical Trial Site | Baltimore | Maryland | 21287 | Recruiting |
| Clinical Trial Site | Boston | Massachusetts | 02115 | Recruiting |
| Clinical Trial Site | Boston | Massachusetts | 02118 | Recruiting |
| Clinical Trial Site | Detroit | Michigan | 48202 | Recruiting |
| Clinical Trial Site | Rochester | Minnesota | 55905 | Recruiting |
| Clinical Trial Site | St Louis | Missouri | 63110 | Recruiting |
| Clinical Trial Site | Manhasset | New York | 11030 | Recruiting |
| Clinical Trial Site | New York | New York | 10029 | Recruiting |
| Clinical Trial Site | New York | New York | 10032 | Recruiting |
| Clinical Trial Site | New York | New York | 10065 | Recruiting |
| Clinical Trial Site | The Bronx | New York | 10467 | Recruiting |
| Clinical Trial Site | Charlotte | North Carolina | 28204 | Recruiting |
| Clinical Trial Site | Cleveland | Ohio | 44195 | Recruiting |
| Clinical Trial Site | Portland | Oregon | 97239 | Recruiting |
| Clinical Trial Site | Lancaster | Pennsylvania | 17602 | Recruiting |
| Clinical Trial Site | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Clinical Trial Site | Charleston | South Carolina | 29425 | Recruiting |
| Clinical Trial Site | Dallas | Texas | 75246 | Recruiting |
| Clinical Trial Site | Houston | Texas | 77030 | Recruiting |
| Clinical Trial Site | Plano | Texas | 75024 | Recruiting |
| Clinical Trial Site | Salt Lake City | Utah | 84132 | Recruiting |
| Clinical Trial Site | Charlottesville | Virginia | 22903 | Recruiting |
| Clinical Trial Site | Falls Church | Virginia | 22042 | Recruiting |
| Clinical Trial Site | Norfolk | Virginia | 23507 | Recruiting |
| Clinical Trial Site | Richmond | Virginia | 23298 | Recruiting |
| Clinical Trial Site | Spokane | Washington | 99204 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 184 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07052903, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 13, 2026 · Synced May 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07052903 live on ClinicalTrials.gov.