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Recruiting Phase 3 Interventional

Single Intravitreal (IVT) Injection of 4D-150 in Patients With Macular Neovascularization Secondary to Age-Related Macular Degeneration

ClinicalTrials.gov ID: NCT07064759

Public ClinicalTrials.gov record NCT07064759. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 29, 2026, 5:55 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-Masked, Active-Controlled Trial of a Single Intravitreal Injection of 4D-150 in Adults With Macular Neovascularization Secondary to Age-Related Macular Degeneration

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This Phase 3 study is evaluating the safety and efficacy of 4D-150 versus aflibercept in participants with neovascular age-related macular degeneration (nAMD). Enrollment in the primary global cohort has been completed; Study centers in Japan remain open for enrollment for the Japan cohort.

Study identification

NCT ID
NCT07064759
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
4D Molecular Therapeutics
Industry
Enrollment
480 participants

Conditions and interventions

Eligibility (public fields only)

Age range
50 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 22, 2025 (Actual)
Primary completion
Nov 2027 (Estimated)
Completion
Nov 2029 (Estimated)
Last update posted
Oct 19, 2026

2025 – 2029

United States locations

U.S. sites
60
U.S. states
27
U.S. cities
58
Facility City State ZIP Site status
Research Network Arizona Scottsdale Arizona 85255 Active, not recruiting
Barnet Dulaney Perkins Eye Center Sun City Arizona 85351 Active, not recruiting
Retina Associates Tucson Arizona 85704 Active, not recruiting
Retinal Diagnostic Center Campbell California 95008 Active, not recruiting
Retina Consultants of Orange County Fullerton California 92835 Active, not recruiting
Northern California Retina Vitreous Associates Mountain View California 94040 Active, not recruiting
Retinal Consultants Medical Group Inc. Sacramento California 95825 Active, not recruiting
Retinal Consultants Medical Group Sacramento California 95841 Active, not recruiting
West Coast Retina Medical Group San Francisco California 94109 Active, not recruiting
Bay Area Retina Associates Walnut Creek California 94598 Active, not recruiting
Retina Consultants of Southern Colorado P.C. Colorado Springs Colorado 80909 Active, not recruiting
Retina Specialists of Colorado Denver Colorado 80222 Active, not recruiting
Southwest Retina Consultants Durango Colorado 81303 Active, not recruiting
ClearVista Clinical Research Hudson Florida 34667 Active, not recruiting
Florida Retina Consultants Lakeland Florida 33805 Active, not recruiting
Florida Retina Institute Orlando Florida 32806 Active, not recruiting
Retina Specialty Institute Pensacola Florida 32503 Active, not recruiting
Retina Vitreous Associates of Florida St. Petersburg Florida 33711 Active, not recruiting
East Florida Eye Institute Stuart Florida 34994 Active, not recruiting
Retina Vitreous Associates of Florida Tampa Florida 33617 Active, not recruiting
Thomas Eye Group Sandy Springs Georgia 30328 Active, not recruiting
Retina Associates, Ltd. Elmhurst Illinois 60126 Active, not recruiting
University Retina and Macula Associates, PC Oak Forest Illinois 60452 Active, not recruiting
Illinois Retina Associates Oak Park Illinois 60304 Active, not recruiting
Springfield Clinic Springfield Illinois 62703 Active, not recruiting
Retina Partners Midwest, PC Carmel Indiana 46032 Active, not recruiting
Haik Humble Eye Center West Monroe Louisiana 71291 Active, not recruiting
The Retina Care Center Baltimore Maryland 21209 Active, not recruiting
Cumberland Valley Retina Consultants Hagerstown Maryland 21740 Active, not recruiting
Mid Atlantic Retina Specialists Hagerstown Maryland 21740 Active, not recruiting
New England Retina Consultants Springfield Massachusetts 01107 Active, not recruiting
Foundation for Vision Research Grand Rapids Michigan 49546 Active, not recruiting
The Retina Institute St Louis Missouri 63128 Active, not recruiting
Sierra Eye Associates Reno Nevada 89502 Active, not recruiting
Envision Ocular, LLC Bloomfield New Jersey 07003 Active, not recruiting
Retina Vitreous Surgeons of CNY PC Liverpool New York 13088 Active, not recruiting
New York Presbyterian Hospital - Columbia University Medical Center New York New York 10032 Active, not recruiting
Vitreoretinal Consultants of NY Westbury New York 11590 Active, not recruiting
North Carolina Retina Associates Cary North Carolina 27511 Active, not recruiting
North Carolina Retina Associates Wake Forest North Carolina 27587 Active, not recruiting
Cincinnati Eye Institute Cincinnati Ohio 45242 Active, not recruiting
Verum Research, LLC Eugene Oregon 947401 Active, not recruiting
EyeHealth Northwest Portland Oregon 97233 Active, not recruiting
Erie Retina Research Erie Pennsylvania 16505 Active, not recruiting
Charleston Neuroscience Institute, LLC Bluffton South Carolina 29910 Active, not recruiting
Carolina Eyecare Physicians Mt. Pleasant South Carolina 29464 Active, not recruiting
Palmetto Retina Center West Columbia South Carolina 29169 Active, not recruiting
Black Hills Regional Eye Institute Rapid City South Dakota 57701 Active, not recruiting
Southeastern Retina Associates Johnson City Tennessee 37604 Active, not recruiting
Tennessee Retina, PC Nashville Tennessee 37203 Active, not recruiting
Southwest Retina Specialist - Panhandle Eye group, LLP Amarillo Texas 79106 Active, not recruiting
Austin Clinical Research Austin Texas 78750 Active, not recruiting
Texas Retina Associate Dallas Texas 75231 Active, not recruiting
Austin Retina Associates San Marcos Texas 78666 Active, not recruiting
Tyler Retina Consultants Tyler Texas 75703 Active, not recruiting
Strategic Clinical Research Willow Park Texas 76087 Active, not recruiting
Rocky Mountain Retina Consultants Salt Lake City Utah 84107 Active, not recruiting
Piedmont Eye Center Lynchburg Virginia 24502 Active, not recruiting
Pacific Northwest Retina Silverdale Washington 98383 Active, not recruiting
Eye Clinic of Wisconsin Wausau Wisconsin 54403 Active, not recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 66 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07064759, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 19, 2026 · Synced Oct 29, 2026

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The complete public registry record, listed eligibility criteria, and available contact information for NCT07064759 live on ClinicalTrials.gov.

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