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Recruiting Phase 3 Interventional

A Randomized Study of Azetukalner Versus Placebo in Major Depressive Disorder (X-NOVA3)

ClinicalTrials.gov ID: NCT07076407

Public ClinicalTrials.gov record NCT07076407. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 8:21 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-blind, Placebo-Controlled, Multicenter Study to Evaluate Azetukalner in Moderate-to-Severe Major Depressive Disorder

Study identification

NCT ID
NCT07076407
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Xenon Pharmaceuticals Inc.
Industry
Enrollment
450 participants

Conditions and interventions

Interventions

  • Azetukalner Drug
  • Placebo Drug

Drug

Eligibility (public fields only)

Age range
18 Years to 74 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 7, 2025
Primary completion
Apr 30, 2027
Completion
Jun 30, 2027
Last update posted
Apr 7, 2026

2025 – 2027

United States locations

U.S. sites
35
U.S. states
18
U.S. cities
33
Facility City State ZIP Site status
Harmonex Neuroscience Research Dothan Alabama 36303 Recruiting
University of Alabama at Birmingham, Huntsville Regional Medical Campus Huntsville Alabama 35801 Recruiting
Pillar Clinical Research Bentonville Arkansas 72712 Recruiting
SanRo Clinical Research Group Bryant Arkansas 72022 Recruiting
Clinical Innovations Inc Bellflower California 90706 Recruiting
Center for Neurohealth La Jolla California 93037 Recruiting
Artemis Institute for Clinical Research San Diego California 92103 Recruiting
California Neuroscience Research Sherman Oaks California 91403 Recruiting
Pacific Clinical Research Management Group Upland California 91786 Recruiting
Institute of Living Hartford Connecticut 06106 Recruiting
Gulfcoast Clinical Research Center Fort Myers Florida 33912 Recruiting
Sarkis Clinical Trials Gainesville Florida 32607 Recruiting
Equipath Health and Research Tampa Bay, Llc Riverview Florida 33578 Recruiting
Delricht Research Atlanta Georgia 30329 Recruiting
Emory University Brain Health Center Atlanta Georgia 30329 Recruiting
Advanced Quality Medical Research Orland Park Illinois 60462 Recruiting
Smart Trials, LLC Jefferson Louisiana 70121 Recruiting
Pharmasite Research Inc. Baltimore Maryland 21208-6605 Recruiting
Adams Clinical Boston Boston Massachusetts 02116 Recruiting
Activmed Practices & Research, Llc - Methuen Methuen Massachusetts 01844 Recruiting
Adams Clinical Watertown Watertown Massachusetts 02472 Recruiting
Vitalix Clinical, Inc Worcester Massachusetts 01608 Recruiting
Psychiatric Care and Research Center O'Fallon Missouri 63368 Recruiting
St. Charles Psychiatric Associates - Midwest Research Group Saint Charles Missouri 63304 Recruiting
Lumina Clinical Research Center Cherry Hill New Jersey 08002 Recruiting
Princeton Medical Institute Princeton New Jersey 08540 Recruiting
Bio Behavioral Health Toms River New Jersey 08755 Recruiting
Bioscience Research, LLC Mount Kisco New York 10549 Recruiting
Fieve Clinical Research, Inc. New York New York 10017 Recruiting
IMA Clinical Research New York New York 10128 Recruiting
Magnolia Clinical Research, Llc Cary North Carolina 27511 Recruiting
Insight Clinical Trials Independence Ohio 44195 Recruiting
Sooner Clinical Research Oklahoma City Oklahoma 73116 Recruiting
Austin Clinical Trial Partners Austin Texas 78737 Recruiting
Boeson Research Provo Utah 84604 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 7 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07076407, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Apr 7, 2026 · Synced May 6, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07076407 live on ClinicalTrials.gov.

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