ClinicalTrials.gov record
Efficacy and Safety of NVX-CoV2705
ClinicalTrials.gov ID: NCT07086222
Public ClinicalTrials.gov record NCT07086222. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 4, Randomized, Double-Blind, Placebo-Controlled, Post-Marketing Study to Evaluate the Efficacy and Safety of an Omicron JN.1 Subvariant SARS-CoV-2 rS Vaccine Adjuvanted With Matrix-M® in Adults 50 to < 65 Years of Age Without High Risk Conditions for Severe COVID-19
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 4, post-market US study, evaluating the efficacy and safety of a single dose of the NVX-CoV2705 Omicron JN.1 COVID-19 vaccine. Approximately 6,500 healthy adults aged 50 to under 65 will be randomized to receive either the vaccine or a placebo, with follow-up for 180 days.
Study identification
- NCT ID
- NCT07086222
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 4
- Enrollment
- 6,500 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 50 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Accepts healthy volunteers
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 20, 2025 (Actual)
- Primary completion
- Nov 18, 2026 (Estimated)
- Completion
- Nov 18, 2026 (Estimated)
- Last update posted
- May 8, 2026
2025 – 2026
United States locations
- U.S. sites
- 99
- U.S. states
- 37
- U.S. cities
- 91
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| North Alabama Research Center | Athens | Alabama | 35611 | — |
| TrialMed - Birmingham | Birmingham | Alabama | 35211 | — |
| Hawthorne Health - Gadsden | Gadsden | Alabama | 35901 | — |
| TrialdMed - Huntsville | Huntsville | Alabama | 35802 | — |
| AMR Mobile | Mobile | Alabama | 36608 | — |
| Headlands Research Scottsdale | Scottsdale | Arizona | 85260 | — |
| Orange Grove Family Practice | Tucson | Arizona | 85741 | — |
| 310 Clinical Research | Inglewood | California | 90301 | — |
| Velocity Clinical Research - San Diego | La Mesa | California | 91942 | — |
| Profound Research LLC at Seaside Medical Group | Oceanside | California | 92058 | — |
| California Research Foundation | San Diego | California | 92123 | — |
| Bayview Research Group, LLC | Valley Village | California | 91607 | — |
| Diablo Clinical Research, Inc. | Walnut Creek | California | 94598 | — |
| Alliance Clinical - West Hills | West Hills | California | 91303 | — |
| Lynn Institute of Denver | Aurora | Colorado | 80012 | — |
| Paradigm Clinical Research Centers, LLC | Wheat Ridge | Colorado | 80033 | — |
| Clinical Research Consulting, LLC | Milford | Connecticut | 06460 | — |
| SIMED Health, LLC / SIMED Research | Gainesville | Florida | 32607 | — |
| Indago Research and Health Center, Inc. | Hialeah | Florida | 33012 | — |
| Health Awareness, LLC | Jupiter | Florida | 33458 | — |
| TrialMed - Melbourne | Melbourne | Florida | 32934 | — |
| Acevedo Clinical Research Associates | Miami | Florida | 33142 | — |
| Research Institute Of South Florida, Inc. | Miami | Florida | 33173 | — |
| MOORE Clinical Research | Tampa | Florida | 33609 | — |
| TrialMed - The Villages | The Villages | Florida | 32162 | — |
| Palm Beach Research Center | West Palm Beach | Florida | 33409 | — |
| CenExel Atlanta GA | Atlanta | Georgia | 30331 | — |
| Centricity Research | Columbus | Georgia | 31904 | — |
| Clinical Research Atlanta | Stockbridge | Georgia | 30281 | — |
| Velocity Clinical Research, Boise | Meridian | Idaho | 83642 | — |
| Accellacare of Duly | Lombard | Illinois | 60148 | — |
| Accellacare Duly Health and Care | Oak Lawn | Illinois | 60453 | — |
| TrialMed | Evansville | Indiana | 47714 | — |
| Velocity Clinical Research, Valparaiso | Valparaiso | Indiana | 46383 | — |
| Velocity Clinical Research, Sioux City | Sioux City | Iowa | 51106 | — |
| Integrated Clinical Trial Services | West Des Moines | Iowa | 50265 | — |
| DelRicht Research @ Concierge and Direct Primary Care | Overland Park | Kansas | 66209 | — |
| Alliance for Multispecialty Research, LLC | Wichita | Kansas | 67207 | — |
| Alliance for Multispecialty Research, L.L.C. | Lexington | Kentucky | 40509 | — |
| DelRicht Research @ Touro Medical Center | New Orleans | Louisiana | 70115 | — |
| DelRicht Research @ Matthew Mintz Clinic | Rockville | Maryland | 20852 | — |
| Profound Research LLC at Millennium Affiliated Physicians | Farmington Hills | Michigan | 48334 | — |
| Great Lakes Research Institute, LLC | Southfield | Michigan | 48075 | — |
| Clinical Research Institute, Inc | Minneapolis | Minnesota | 55402 | — |
| DelRicht Research at Gulfport Memorial | Gulfport | Mississippi | 39503 | — |
| AMR Kansas City | Kansas City | Missouri | 64114 | — |
| Sundance Clinical Research | St Louis | Missouri | 63141 | — |
| Boeson Research | Missoula | Montana | 59804 | — |
| Velocity Clinical Research, Lincoln | Lincoln | Nebraska | 68510 | — |
| Velocity Clinical Research | Norfolk | Nebraska | 68701 | — |
| Velocity Clinical Research, Omaha | Omaha | Nebraska | 68134 | — |
| Excel Clinical Research | Las Vegas | Nevada | 89109 | — |
| TrialMed - Las Vegas | Las Vegas | Nevada | 89113 | — |
| AMR Clinical - Las Vegas | Las Vegas | Nevada | 89119 | — |
| Hawthorne Health - Lindenwold | Lindenwold | New Jersey | 08021 | — |
| IMA Clinical Research - Albuquerque | Albuquerque | New Mexico | 87109 | — |
| Velocity Clinical Research - Binghampton | Binghamton | New York | 13905 | — |
| Rochester Clinical Research | Buffalo | New York | 14217 | — |
| Rochester Clinical Research, LLC | Rochester | New York | 14609 | — |
| Hawthorne Health - Staten | Staten Island | New York | 10309 | — |
| Hawthorne Health - Concord | Concord | North Carolina | 28025 | — |
| Monroe Pharmaceutical Research | Monroe | North Carolina | 28112 | — |
| Accellacare of Rocky Mount | Rocky Mount | North Carolina | 27804 | — |
| Accellacare Research of Salisbury | Salisbury | North Carolina | 28144 | — |
| Accellacare Research of Winston Salem | Winston-Salem | North Carolina | 27103 | — |
| DSI Research - Northridge | Dayton | Ohio | 45414 | — |
| Lynn Institute of Norman | Norman | Oklahoma | 73072 | — |
| Lynn Health Institute - OKC | Oklahoma City | Oklahoma | 73112 | — |
| DelRicht Research @ Grassroots Healthcare | Tulsa | Oklahoma | 74133 | — |
| Velocity Clinical Research, Medford | Medford | Oregon | 97504 | — |
| Capital Area Research, LLC | Camp Hill | Pennsylvania | 17011 | — |
| Hawthorne Health - Horsham | Horsham | Pennsylvania | 19044 | — |
| Suburban Research Associates - West Chester Office | West Chester | Pennsylvania | 19380 | — |
| K2 Medical Research - East Providence | East Providence | Rhode Island | 02914 | — |
| DelRicht Research @ Newton Family Medicine | Charleston | South Carolina | 29407 | — |
| Piedmont Research Partners | Fort Mill | South Carolina | 29707 | — |
| Trial Management Associates (TMA ) Headlands LLC | Myrtle Beach | South Carolina | 29572 | — |
| Accellacare of Bristol | Bristol | Tennessee | 37620 | — |
| WR Clinsearch, LLC | Chattanooga | Tennessee | 37421 | — |
| Summit-Halls Family Practice | Knoxville | Tennessee | 37938 | — |
| Hawthorne Health - Lebanon | Lebanon | Tennessee | 37087 | — |
| International Clinical Research - Tennessee | Murfreesboro | Tennessee | 37130 | — |
| Avacare | Austin | Texas | 78705 | — |
| TrialMed - Austin | Austin | Texas | 78744 | — |
| Howland Allergy & Asthma PLLC dba Orion Clinical Research | Austin | Texas | 78759 | — |
| Zenos Clinical Research | Dallas | Texas | 75230 | — |
| Avacare | Fort Worth | Texas | 76135 | — |
| SMS Clinical Research LLC | Mesquite | Texas | 75149 | — |
| ACRC Trials | Plano | Texas | 75093 | — |
| Research Your Health | Plano | Texas | 75093 | — |
| Flourish San Antonio - Clinical | San Antonio | Texas | 78229 | — |
| TrialMed - San Antonio | San Antonio | Texas | 78229 | — |
| Sugar Lakes Family Practice, P.A. | Sugar Land | Texas | 77479 | — |
| Boeson Research - Utah | Provo | Utah | 84604 | — |
| University of Utah | Salt Lake City | Utah | 84108 | — |
| J. Lewis Research, Inc. / Foothill Family Clinic | Salt Lake City | Utah | 84109 | — |
| Charlottesville Medical Research Center, LLC | Charlottesville | Virginia | 22911 | — |
| Health Research of Hampton Roads, Inc | Newport News | Virginia | 23606 | — |
| Velocity Clinical Research, Seattle | Seattle | Washington | 98105 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07086222, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 8, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07086222 live on ClinicalTrials.gov.