Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)

ClinicalTrials.gov ID: NCT07100080

Public ClinicalTrials.gov record NCT07100080. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 5, 2026, 11:29 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

IZABRIGHT-Lung01: A Randomized, Open-label, Phase 2/3 Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-based Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Disease Progression on EGFR Tyrosine Kinase Inhibitor Therapy

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

A Study of Izalontamab Brengitecan (BMS-986507) versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer after failure of EGFR TKI Therapy

Study identification

NCT ID: NCT07100080
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 2, Phase 3
Lead sponsor: Bristol-Myers Squibb; Industry
Enrollment: 500 participants

Conditions and interventions

Conditions

Non-Small Cell Lung Cancer

Interventions

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Nov 4, 2025
Primary completion: Dec 14, 2028
Completion: Nov 14, 2030
Last update posted: Aug 24, 2026

2025 – 2030

United States locations

U.S. sites: 28
U.S. states: 15
U.S. cities: 25

Facility	City	State	ZIP	Site status
UCI Health - Chao Family Comprehensive Cancer Center and Ambulatory Care building	Irvine	California	92612	Recruiting
University of California, Irvine (UCI) Health - UC Irvine Medical Center	Orange	California	92868-3201	Recruiting
Shaw Cancer Center	Edwards	Colorado	81632	Recruiting
Local Institution - 0085	Gainesville	Florida	32610	Withdrawn
Local Institution - 0142	Pembroke Pines	Florida	33028	Not yet recruiting
Piedmont Healthcare	Atlanta	Georgia	30318	Recruiting
John B Amos Cancer Center	Columbus	Georgia	31904	Recruiting
Rush University Medical Center	Chicago	Illinois	60607	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Recruiting
Washington University School of Medicine	St Louis	Missouri	63108	Recruiting
Renown Regional Medical Center	Reno	Nevada	89502	Recruiting
Perlmutter Cancer Center at NYU Langone Hospital - Long Island	Mineola	New York	11501	Recruiting
NYU Langone Health	New York	New York	10016	Recruiting
Weill Cornell Medical College	New York	New York	10065	Recruiting
Rochester General Hospital Infectious Disease	Rochester	New York	14621	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive C	Columbus	Ohio	43210	Recruiting
Providence Cancer Institute Franz Clinic	Portland	Oregon	97213	Recruiting
Providence St. Vincent Medical Center	Portland	Oregon	97225	Recruiting
Oregon Health and Science University	Portland	Oregon	97239	Recruiting
Hospital of the University of Pennsylvania	Philadelphia	Pennsylvania	19104	Recruiting
West Penn Allegheny Health	Pittsburgh	Pennsylvania	15224	Recruiting
Local Institution - 0268	Chattanooga	Tennessee	37404	Withdrawn
Tennessee Oncology	Nashville	Tennessee	37203	Recruiting
Local Institution - 0025	Houston	Texas	77030	Not yet recruiting
Local Institution - 0173	San Antonio	Texas	78229	Not yet recruiting
University of Virginia Health System	Charlottesville	Virginia	22908	Recruiting
Virginia Commonwealth University (Vcu)	Richmond	Virginia	23219	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 158 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07100080, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 24, 2026 · Synced Sep 5, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07100080 live on ClinicalTrials.gov.

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