Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-Pemetrexed for EGFR-mutated Non-small Cell Lung Cancer After Failure of EGFR TKI Therapy (IZABRIGHT-Lung01)
Public ClinicalTrials.gov record NCT07100080. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
IZABRIGHT-Lung01: A Randomized, Open-label, Phase 2/3 Study of Izalontamab Brengitecan (BMS-986507) Versus Platinum-based Chemotherapy in Patients With EGFR-mutated Non-small Cell Lung Cancer and Disease Progression on EGFR Tyrosine Kinase Inhibitor Therapy
Study identification
- NCT ID
- NCT07100080
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- Bristol-Myers Squibb
- Industry
- Enrollment
- 596 participants
Conditions and interventions
Conditions
Interventions
- Carboplatin Drug
- Cisplatin Drug
- Iza-bren Drug
- Pemetrexed Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 4, 2025
- Primary completion
- Sep 14, 2028
- Completion
- May 14, 2031
- Last update posted
- Apr 15, 2026
2025 – 2031
United States locations
- U.S. sites
- 28
- U.S. states
- 15
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0279 | Irvine | California | 92612 | Not yet recruiting |
| Local Institution - 0154 | Orange | California | 92868 | Not yet recruiting |
| Shaw Cancer Center | Edwards | Colorado | 81632 | Recruiting |
| Local Institution - 0085 | Gainesville | Florida | 32610 | Withdrawn |
| Local Institution - 0142 | Pembroke Pines | Florida | 33028 | Not yet recruiting |
| Piedmont Healthcare | Atlanta | Georgia | 30318 | Recruiting |
| John B Amos Cancer Center | Columbus | Georgia | 31904 | Recruiting |
| Local Institution - 0153 | Chicago | Illinois | 60612 | Not yet recruiting |
| Dana-Farber Cancer Institute | Boston | Massachusetts | 02215 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63108 | Recruiting |
| Renown Regional Medical Center | Reno | Nevada | 89502 | Recruiting |
| Perlmutter Cancer Center at NYU Langone Hospital - Long Island | Mineola | New York | 11501 | Recruiting |
| NYU Langone Health | New York | New York | 10016 | Recruiting |
| Local Institution - 0158 | New York | New York | 10065 | Not yet recruiting |
| Rochester General Hospital Infectious Disease | Rochester | New York | 14621 | Recruiting |
| University Hospitals Cleveland Medical Center | Cleveland | Ohio | 44106 | Recruiting |
| Local Institution - 0284 | Columbus | Ohio | 43210 | Not yet recruiting |
| Providence Cancer Institute Franz Clinic | Portland | Oregon | 97213 | Recruiting |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | Recruiting |
| Local Institution - 0171 | Portland | Oregon | 97239 | Not yet recruiting |
| Hospital of the University of Pennsylvania | Philadelphia | Pennsylvania | 19104 | Recruiting |
| Local Institution - 0088 | Pittsburgh | Pennsylvania | 15212 | Not yet recruiting |
| Local Institution - 0268 | Chattanooga | Tennessee | 37404 | Withdrawn |
| Tennessee Oncology | Nashville | Tennessee | 37203 | Recruiting |
| Local Institution - 0025 | Houston | Texas | 77030 | Not yet recruiting |
| Local Institution - 0173 | San Antonio | Texas | 78229 | Not yet recruiting |
| University of Virginia Health System | Charlottesville | Virginia | 22908 | Recruiting |
| Virginia Commonwealth University (Vcu) | Richmond | Virginia | 23219 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 158 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07100080, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 15, 2026 · Synced May 6, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07100080 live on ClinicalTrials.gov.