A Study to Evaluate the Effect of GDC-4198 Alone and in Combination With Giredestrant Versus Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive (ER+), Human Epidermal Growth Factor Receptor-Negative (HER2-) Breast Cancer
Public ClinicalTrials.gov record NCT07100106. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase Ib/II Multicenter, Open-Label, Randomized Study Evaluating the Safety, Pharmacokinetics, and Activity of GDC-4198 Alone and in Combination With Giredestrant in Comparison With Abemaciclib and Giredestrant in Participants With Locally Advanced or Metastatic Estrogen Receptor-Positive, HER2-Negative Breast Cancer Who Have Previously Progressed During or After a CDK4/6 Inhibitor
Study identification
- NCT ID
- NCT07100106
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Lead sponsor
- Genentech, Inc.
- Industry
- Enrollment
- 285 participants
Conditions and interventions
Conditions
Interventions
- Abemaciclib Drug
- GDC-4198 Drug
- Giredestrant Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 6, 2025
- Primary completion
- Aug 30, 2028
- Completion
- Aug 30, 2028
- Last update posted
- Apr 20, 2026
2025 – 2028
United States locations
- U.S. sites
- 14
- U.S. states
- 11
- U.S. cities
- 14
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| City of Hope | Duarte | California | 91010 | Recruiting |
| City of Hope - Orange County Lennar Foundation Cancer Center | Irvine | California | 92618 | Recruiting |
| UCSF Helen Diller Family CCC | San Francisco | California | 94158 | Recruiting |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Recruiting |
| Winship Cancer Institute of Emory University | Atlanta | Georgia | 30322-1013 | Recruiting |
| City of Hope® Cancer Center Chicago | Zion | Illinois | 60099 | Recruiting |
| Barbara Ann Karmanos Cancer Institute | Detroit | Maine | 48201-2013 | Recruiting |
| Washington University Siteman Cancer Center | St Louis | Missouri | 63110-1010 | Recruiting |
| Rutgers Cancer Institute of New Jersey | New Brunswick | New Jersey | 08901-1914 | Recruiting |
| New York Cancer & Blood Specialists | East Patchogue | New York | 11772 | Recruiting |
| University of Pennsylvania - Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | Recruiting |
| UPMC - Hillman Cancer Center | Pittsburgh | Pennsylvania | 15213-3108 | Recruiting |
| Vanderbilt Breast Center at One Hundred Oaks | Nashville | Tennessee | 37204-3609 | Recruiting |
| Texas Oncology (Worth) - USOR | Dallas | Texas | 75246-2003 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 21 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07100106, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 20, 2026 · Synced May 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07100106 live on ClinicalTrials.gov.