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Recruiting Phase 3 Interventional

Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

ClinicalTrials.gov ID: NCT07100990

Public ClinicalTrials.gov record NCT07100990. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 6, 2026, 2:09 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Controlled, Open-Label, Rater-Blinded Pragmatic Trial, Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this research is to evaluate if early vs rescue Therapeutic Plasma Exchange (PLEX) treatment algorithm leads to better visual outcomes in severe Optic Neuritis and leads to better neurological disability outcomes in severe Transverse Myelitis.

Study identification

NCT ID
NCT07100990
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Mayo Clinic
Other
Enrollment
382 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Jul 10, 2025
Primary completion
Mar 31, 2029
Completion
Apr 29, 2031
Last update posted
Jul 5, 2026

2025 – 2031

United States locations

U.S. sites
33
U.S. states
23
U.S. cities
28
Facility City State ZIP Site status
Mayo Clinic Arizona Scottsdale Arizona 85259 Recruiting
Loma Linda University Loma Linda California 92350 Active, not recruiting
University of California, Davis Sacramento California 95817 Recruiting
University of Colorado - Anschutz Medical Aurora Colorado 80045 Recruiting
Yale University School of Medicine North Haven Connecticut 06510 Recruiting
Mayo Clinic Florida Jacksonville Florida 32224 Recruiting
University of Miami Miami Florida 33136 Recruiting
University of Illinois Chicago Chicago Illinois 60612 Recruiting
Northwestern University Evanston Illinois 60208 Recruiting
Indiana University Indianapolis Indiana 46202 Recruiting
University of Maryland, Baltimore Baltimore Maryland 21201 Recruiting
Johns Hopkins University Baltimore Maryland 21218 Recruiting
Medstar Health Research Institute Columbia Maryland 21044 Recruiting
Harvard University Massachusetts General Hospital Boston Massachusetts 02114 Recruiting
Boston Medical Center Boston Massachusetts 02118 Recruiting
Regents of the University of Michigan Ann Arbor Michigan 48105 Recruiting
Mayo Clinic in Rochester Rochester Minnesota 55905 Recruiting
University of Mississippi Medical Center Jackson Mississippi 39216 Recruiting
NYU Langone Health New York New York 10016 Active, not recruiting
Icahn School of Medicine at Mount Sinai New York New York 10029 Recruiting
Columbia University New York New York 10032 Recruiting
Weill Cornell Medical College New York New York 10065 Recruiting
University of North Carolina School of Medicine Chapel Hill North Carolina 27599 Active, not recruiting
Duke University Health System Durham North Carolina 27710 Recruiting
University Hospitals Cleveland Medical Center Cleveland Ohio 44106 Recruiting
Dean McGee Eye Institute at University of Oklahoma Health Sciences Oklahoma City Oklahoma 73117 Active, not recruiting
Oregon Health & Sciences University Portland Oregon 97239 Recruiting
University of Pittsburgh Medical Center, Magee Hospital Pittsburgh Pennsylvania 15213 Recruiting
Vanderbilt University Medical Center Nashville Tennessee 37232 Recruiting
UT Southwestern Medical Center Dallas Texas 75390 Recruiting
University of Utah Salt Lake City Utah 84112 Recruiting
University of Virginia Charlottesville Virginia 22908 Recruiting
University of Washington Seattle Washington 98195 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07100990, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 5, 2026 · Synced Sep 6, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07100990 live on ClinicalTrials.gov.

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