Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

ClinicalTrials.gov ID: NCT07100990

Public ClinicalTrials.gov record NCT07100990. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced May 6, 2026, 2:06 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized Controlled, Open-Label, Rater-Blinded Pragmatic Trial, Treatment of Inflammatory Myelitis and Optic Neuritis With Early vs Rescue Plasma Exchange (TIMELY-PLEX)

Study identification

NCT ID: NCT07100990
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Mayo Clinic; Other
Enrollment: 382 participants

Conditions and interventions

Conditions

Interventions

High-dose corticosteroids (HDCS) Drug
High-dose corticosteroids (HDCS) and PLEX Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Jul 10, 2025
Primary completion: Mar 31, 2029
Completion: Apr 29, 2031
Last update posted: May 4, 2026

2025 – 2031

United States locations

U.S. sites: 31
U.S. states: 23
U.S. cities: 26

Facility	City	State	ZIP	Site status
Mayo Clinic Arizona	Scottsdale	Arizona	85259	Recruiting
University of California, Davis	Sacramento	California	95817	Active, not recruiting
University of Colorado - Anschutz Medical	Aurora	Colorado	80045	Recruiting
Yale University School of Medicine	North Haven	Connecticut	06510	Recruiting
Mayo Clinic Florida	Jacksonville	Florida	32224	Active, not recruiting
University of Miami	Miami	Florida	33136	Recruiting
University of Illinois Chicago	Chicago	Illinois	60612	Recruiting
Northwestern University	Evanston	Illinois	60208	Recruiting
Indiana University	Indianapolis	Indiana	46202	Recruiting
University of Maryland, Baltimore	Baltimore	Maryland	21201	Recruiting
Johns Hopkins University	Baltimore	Maryland	21218	Recruiting
Medstar Health Research Institute	Columbia	Maryland	21044	Recruiting
Harvard University Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Boston Medical Center	Boston	Massachusetts	02118	Recruiting
Regents of the University of Michigan	Ann Arbor	Michigan	48105	Recruiting
Mayo Clinic in Rochester	Rochester	Minnesota	55905	Recruiting
University of Mississippi Medical Center	Jackson	Mississippi	39216	Recruiting
NYU Langone Health	New York	New York	10016	Active, not recruiting
Icahn School of Medicine at Mount Sinai	New York	New York	10029	Recruiting
Columbia University	New York	New York	10032	Recruiting
Weill Cornell Medical College	New York	New York	10065	Recruiting
Duke University Health System	Durham	North Carolina	27710	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Active, not recruiting
Dean McGee Eye Institute at University of Oklahoma Health Sciences	Oklahoma City	Oklahoma	73117	Active, not recruiting
Oregon Health & Sciences University	Portland	Oregon	97239	Recruiting
University of Pittsburgh Medical Center, Magee Hospital	Pittsburgh	Pennsylvania	15213	Recruiting
Vanderbilt University Medical Center	Nashville	Tennessee	37232	Recruiting
UT Southwestern Medical Center	Dallas	Texas	75390	Recruiting
University of Utah	Salt Lake City	Utah	84112	Recruiting
University of Virginia	Charlottesville	Virginia	22908	Active, not recruiting
University of Washington	Seattle	Washington	98195	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07100990, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 4, 2026 · Synced May 6, 2026

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The complete protocol, eligibility criteria, and contact information for NCT07100990 live on ClinicalTrials.gov.

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