A Study of LY4152199 in Participants With Previously Treated B-cell Malignancies (BAF_FRontier-1 )

ClinicalTrials.gov ID: NCT07101328

Public ClinicalTrials.gov record NCT07101328. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 10, 2026, 9:13 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

BAF_FRontier-1, A First-in-Human, Phase 1 Trial to Assess Safety, Tolerability, and Preliminary Efficacy of LY4152199, a B-cell Activation Factor Receptor (BAFF-R) T-Cell Engager Bispecific Antibody in Adult Participants With Previously Treated B-cell Malignancies

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to find the best dose of the drug and measure the safety and efficacy of LY4152199 in participants with previously treated B-cell malignancies. Participants will have the option to continue taking LY4152199 until the study ends.

Study identification

NCT ID: NCT07101328
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: Eli Lilly and Company; Industry
Enrollment: 215 participants

Conditions and interventions

Conditions

Interventions

LY4152199 - IV Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: May 27, 2026
Primary completion: Mar 31, 2027
Completion: Aug 31, 2029
Last update posted: Sep 7, 2026

2026 – 2029

United States locations

U.S. sites: 23
U.S. states: 18
U.S. cities: 20

Facility	City	State	ZIP	Site status
City of Hope	Duarte	California	91010	Recruiting
University of Colorado Denver - School of Medicine - Anschutz Medical Campus	Aurora	Colorado	80045-2559	Recruiting
Colorado Blood Cancer Institute	Denver	Colorado	80218	Recruiting
Yale University School of Medicine - Yale Cancer Center	New Haven	Connecticut	06520-8028	Recruiting
The University of Chicago Medical Center (UCMC)	Chicago	Illinois	60637	Recruiting
University of Iowa	Iowa City	Iowa	52242	Recruiting
University of Kansas Cancer Center	Kansas City	Kansas	66160	Recruiting
Massachusetts General Hospital	Boston	Massachusetts	02114	Recruiting
Dana-Farber Cancer Institute	Boston	Massachusetts	02215	Not yet recruiting
University of Michigan Comprehensive Cancer Center	Ann Arbor	Michigan	48109	Recruiting
Mayo Clinic - Rochester	Rochester	Minnesota	55905	Recruiting
Rutgers Cancer Institute of New Jersey	New Brunswick	New Jersey	08901	Not yet recruiting
New York University (NYU) Clinical Cancer Center	New York	New York	10016	Recruiting
Weill Cornell Medicine	New York	New York	10021	Recruiting
David H. Koch Center for Cancer Care at Memorial Sloan Kettering Cancer Center	New York	New York	10065	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
University of Pennsylvania Abramson Cancer Center	Philadelphia	Pennsylvania	19104	Recruiting
SCRI Oncology Partners	Nashville	Tennessee	37203	Recruiting
University of Texas Southwestern	Dallas	Texas	75244	Recruiting
MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
Intermountain Healthcare	Salt Lake City	Utah	84111	Not yet recruiting
Swedish Cancer Institute (SCI)	Seattle	Washington	98104	Recruiting
Froedtert Hospital and the Medical College of Wisconsin	Milwaukee	Wisconsin	53226	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 28 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07101328, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Sep 7, 2026 · Synced Sep 10, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07101328 live on ClinicalTrials.gov.

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