A Phase 2 Neoadjuvant Study of Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer
Public ClinicalTrials.gov record NCT07102381. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Multicenter, Open-label Neoadjuvant Study Evaluating Zanidatamab in Combination With Chemotherapy in Participants With HER2-positive Breast Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to see if zanidatamab is safe and effective, when combined with chemotherapy, in treating people who has Human Epidermal Growth Factor Receptor 2 (HER2)-positive, early-stage breast cancer
Study identification
- NCT ID
- NCT07102381
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 125 participants
Conditions and interventions
Conditions
Interventions
- Zanidatamab Drug
- Paclitaxel Drug
- Docetaxel Drug
- Carboplatin Drug
- Trastuzumab Drug
- Pertuzumab Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 23, 2025
- Primary completion
- Dec 31, 2027
- Completion
- Jul 31, 2030
- Last update posted
- Aug 24, 2026
2025 – 2030
United States locations
- U.S. sites
- 29
- U.S. states
- 18
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Oncology Institute | Long Beach | California | 90805 | Recruiting |
| Cancer & Blood Research Center | Los Alamitos | California | 90720 | Recruiting |
| Rocky Mountain Cancer Centers | Denver | Colorado | 80218 | Recruiting |
| Holy Cross Hospital | Fort Lauderdale | Florida | 33308 | Recruiting |
| The Oncology Institute | Lakeland | Florida | 33812 | Recruiting |
| Accellacare of McFarland | Ames | Iowa | 50010 | Recruiting |
| LSU Health Sciences Center | Shreveport | Louisiana | 71103 | Recruiting |
| New England Cancer Specialists | Scarborough | Maine | 04074 | Recruiting |
| Maryland Oncology Hematology | Laurel | Maryland | 20707 | Recruiting |
| Henry Ford Hospital | Detroit | Michigan | 48202 | Recruiting |
| Cancer Partners of Nebraska | Lincoln | Nebraska | 68516 | Recruiting |
| Nebraska Cancer Specialists | Omaha | Nebraska | 68124 | Recruiting |
| Astera Cancer Care (Formerly Regional Cancer Care Associates) | East Brunswick | New Jersey | 08816 | Recruiting |
| Medical Oncology Hematology Associates | Newark | New Jersey | 19713 | Recruiting |
| The University of New Mexico | Albuquerque | New Mexico | 87131 | Recruiting |
| Hematology Oncology Associates of Central New York | Camillus | New York | 13031 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Levine Cancer | Charlotte | North Carolina | 28204 | Recruiting |
| Sarah Cannon Research Institute (Nashville) | Nashville | Tennessee | 37203 | Recruiting |
| Texas Oncology DFW | Dallas | Texas | 75246 | Recruiting |
| The University of Texas Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| Texas Oncology Gulf Coast | Houston | Texas | 77024 | Recruiting |
| UT Health San Antonio, Mays Cancer Center | San Antonio | Texas | 78229 | Recruiting |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | Recruiting |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | Recruiting |
| Shenandoah Oncology | Winchester | Virginia | 22601 | Recruiting |
| Northwest Medical Specialties | Puyallup | Washington | 98373 | Recruiting |
| Northwest Cancer Specialists | Vancouver | Washington | 98648 | Recruiting |
| University of Wisconsin | Madison | Wisconsin | 53706 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 6 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07102381, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 24, 2026 · Synced Sep 14, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07102381 live on ClinicalTrials.gov.