Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer With Disease Progression on or After Immunotherapy
Public ClinicalTrials.gov record NCT07106762. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
IZABRIGHT-Bladder01: A Randomized, Open-label, Phase 2/3 Trial of Izalontamab Brengitecan Versus Platinum-based Chemotherapy for Metastatic Urothelial Cancer in Participants With Disease Progression on or After an Immunotherapy-based Treatment
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
A Phase 2/3 Trial of Izalontamab Brengitecan vs Platinum-based Chemotherapy for Metastatic Urothelial Cancer with Disease Progression on or After Immunotherapy
Study identification
- NCT ID
- NCT07106762
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 470 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 29, 2025
- Primary completion
- Jan 25, 2029
- Completion
- Nov 17, 2033
- Last update posted
- Jul 28, 2026
2025 – 2033
United States locations
- U.S. sites
- 35
- U.S. states
- 17
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0167 | Gilbert | Arizona | 85234 | Not yet recruiting |
| Local Institution - 0162 | Fullerton | California | 92835 | Not yet recruiting |
| Palo Alto Center-Palo Alto Medical Foundation Research Institute | Palo Alto | California | 94304 | Recruiting |
| Sutter Health - Sutter Institute for Medical Research | Sacramento | California | 95816 | Recruiting |
| University of California Davis (UC Davis) Comprehensive Cancer Center | Sacramento | California | 95817 | Recruiting |
| Pacific Hematology Oncology Associates | San Francisco | California | 94115 | Recruiting |
| Sutter Santa Rosa | Santa Rosa | California | 95403 | Recruiting |
| Rocky Mountain Cancer Centers, LLP | Denver | Colorado | 80218 | Recruiting |
| Local Institution - 0245 | Dillon | Colorado | 80435 | Withdrawn |
| Shaw Cancer Center | Edwards | Colorado | 81632 | Recruiting |
| Sibley Memorial Hospital | Washington D.C. | District of Columbia | 20016 | Recruiting |
| Miami Cancer Institute at Baptist Health, Inc. | Miami | Florida | 33176 | Recruiting |
| University of Kentucky Chandler Medical Center | Lexington | Kentucky | 40536 | Recruiting |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | Recruiting |
| Local Institution - 0195 | Boston | Massachusetts | 02215 | Not yet recruiting |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | Recruiting |
| Local Institution - 0248 | Buffalo | New York | 14203 | Withdrawn |
| Icahn School of Medicine at Mount Sinai | New York | New York | 10029 | Recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Fairview Hospital | Cleveland | Ohio | 44111 | Recruiting |
| Cleveland Clinic | Cleveland | Ohio | 44195 | Recruiting |
| The James Outpatient Care West Campus | Columbus | Ohio | 43221 | Recruiting |
| Cleveland Clinic - Hillcrest Hospital | Mayfield Heights | Ohio | 44124 | Recruiting |
| Local Institution - 0141 | Portland | Oregon | 97239 | Not yet recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Local Institution - 0084 | Nashville | Tennessee | 37232 | Not yet recruiting |
| Texas Oncology - West Texas | Abilene | Texas | 79606 | Recruiting |
| Local Institution - 0187 | Austin | Texas | 78705 | Not yet recruiting |
| Intermountain Medical Center | Murray | Utah | 84107 | Recruiting |
| St George Regional Hospital Cancer Center | St. George | Utah | 84790 | Recruiting |
| University of Virginia Health System | Charlottesville | Virginia | 22903 | Recruiting |
| Local Institution - 0188 | Norfolk | Virginia | 23502 | Not yet recruiting |
| Local Institution - 0200 | Seattle | Washington | 98101 | Not yet recruiting |
| Fred Hutchinson Cancer Center | Seattle | Washington | 98109 | Recruiting |
| University of Washington Medical Center - Montlake | Seattle | Washington | 98195 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 128 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07106762, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Jul 28, 2026 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07106762 live on ClinicalTrials.gov.