A Study to Assess the Efficacy and Safety of Zipalertinib Versus Placebo for Adjuvant Treatment in Participants With Stage IB-IIIA NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection
Public ClinicalTrials.gov record NCT07128199. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Randomized, Placebo-Controlled, Double-Blind, Multi-Center Phase 3 Study of Zipalertinib Plus Adjuvant Chemotherapy Versus Placebo Plus Adjuvant Chemotherapy in Stage IB-IIIA NSCLC Patients With Uncommon EGFR Mutations Following Complete Tumor Resection (REZILIENT4)
Study identification
- NCT ID
- NCT07128199
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Taiho Oncology, Inc.
- Industry
- Enrollment
- 360 participants
Conditions and interventions
Conditions
Interventions
- Carboplatin Drug
- Cisplatin Drug
- Pemetrexed Drug
- TAS6417 Drug
- Zipalertinib Matching-placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 21, 2025
- Primary completion
- Sep 30, 2029
- Completion
- Sep 30, 2032
- Last update posted
- May 4, 2026
2025 – 2032
United States locations
- U.S. sites
- 30
- U.S. states
- 13
- U.S. cities
- 29
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alaska Oncology and Hematology | Anchorage | Alaska | 99508 | — |
| City of Hope Comprehensive Cancer Center - Duarte | Duarte | California | 91010 | — |
| City of Hope Comprehensive Cancer Center Orange County Lennar Foundation Cancer Center | Irvine | California | 92618 | — |
| Scripps Clinic Torrey Pines | La Jolla | California | 92037 | — |
| Kaiser Permanente - Vallejo Medical Center | Vallejo | California | 94589 | — |
| Georgetown University School of Medicine | Washington D.C. | District of Columbia | 20007 | — |
| D&H Cancer Research Center - Margate | Margate | Florida | 33063 | — |
| Alpha Oncology Research | Orange City | Florida | 32763 | — |
| City of Hope - Atlanta | Newnan | Georgia | 30265 | — |
| University of Illinois Medical Center | Chicago | Illinois | 60612 | — |
| Profound Research LLC at Michigan Hematology and Oncology Consultants | Dearborn | Michigan | 48126 | — |
| Henry Ford Health System | Detroit | Michigan | 48202 | — |
| Memorial Sloan Kettering Cancer Center - Basking Ridge | Basking Ridge | New Jersey | 07920 | — |
| Memorial Sloan Kettering Cancer Center - Monmouth | Middletown | New Jersey | 07748 | — |
| Memorial Sloan Kettering Cancer Center - Bergen | Montvale | New Jersey | 07645 | — |
| Memorial Sloan Kettering Cancer Center - Commack | Commack | New York | 11725 | — |
| Memorial Sloan Kettering Cancer Center - Westchester | Harrison | New York | 10604 | — |
| Long Island Jewish Medical Center | Lake Success | New York | 11042 | — |
| Perlmutter Cancer Center - 34th Street | New York | New York | 10016 | — |
| Memorial Sloan Kettering Cancer Center - New York | New York | New York | 10065 | — |
| Memorial Sloan Kettering Cancer Center - Nassau | Uniondale | New York | 11553 | — |
| Atrium Health Wake Forest Baptist - Comprehensive Cancer Center | Charlotte | North Carolina | 28204 | — |
| Durham Veterans Affairs Health Care System | Durham | North Carolina | 27705 | — |
| Gabrail Cancer and Research Center | Canton | Ohio | 44718 | — |
| Gibbs Cancer Center and Research Institute Spartanburg | Spartanburg | South Carolina | 29303 | — |
| Virginia Cancer Specialists - Arlington Office | Arlington | Virginia | 22201 | — |
| Virginia Cancer Specialists - Fairfax Office | Fairfax | Virginia | 22031 | — |
| Virginia Cancer Specialists - Bristow Office | Manassas | Virginia | 20110 | — |
| Virginia Cancer Specialists - Reston | Reston | Virginia | 20190 | — |
| Virginia Cancer Specialists - Woodbridge Office | Woodbridge | Virginia | 22191 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 222 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07128199, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 4, 2026 · Synced May 10, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07128199 live on ClinicalTrials.gov.