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Recruiting Phase 3 Interventional

A Study to Assess Zipalertinib Versus Placebo in Participants With Early Stage NSCLC With Uncommon EGFR Mutations, Following Complete Tumor Resection

ClinicalTrials.gov ID: NCT07128199

Public ClinicalTrials.gov record NCT07128199. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 17, 2026, 11:05 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Placebo-Controlled, Double-Blind, Multi-Center Phase 3 Study of Zipalertinib Versus Placebo in Early Stage NSCLC Patients With Uncommon EGFR Mutations Following Complete Tumor Resection (REZILIENT4)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to compare the efficacy of zipalertinib versus placebo in participants with early stage resected non-small cell lung cancer (NSCLC) harboring uncommon epidermal growth factor receptor mutation (EGFRmt).

Study identification

NCT ID
NCT07128199
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
Taiho Oncology, Inc.
Industry
Enrollment
360 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 22, 2025 (Actual)
Primary completion
Oct 1, 2029 (Estimated)
Completion
Oct 1, 2032 (Estimated)
Last update posted
Oct 13, 2026

2025 – 2032

United States locations

U.S. sites
30
U.S. states
13
U.S. cities
29
Facility City State ZIP Site status
Alaska Oncology and Hematology Anchorage Alaska 99508 Recruiting
City of Hope Comprehensive Cancer Center - Duarte Duarte California 91010 Not yet recruiting
City of Hope Comprehensive Cancer Center Orange County Lennar Foundation Cancer Center Irvine California 92618 Not yet recruiting
Scripps Clinic Torrey Pines La Jolla California 92037 Not yet recruiting
Kaiser Permanente - Vallejo Medical Center Vallejo California 94589 Not yet recruiting
Georgetown University School of Medicine Washington D.C. District of Columbia 20007 Recruiting
D&H Cancer Research Center - Margate Margate Florida 33063 Recruiting
Alpha Oncology Research Orange City Florida 32763 Recruiting
City of Hope - Atlanta Newnan Georgia 30265 Not yet recruiting
University of Illinois Medical Center Chicago Illinois 60612 Recruiting
Profound Research LLC at Michigan Hematology and Oncology Consultants Dearborn Michigan 48126 Recruiting
Henry Ford Health System Detroit Michigan 48202 Not yet recruiting
Memorial Sloan Kettering Cancer Center - Basking Ridge Basking Ridge New Jersey 07920 Not yet recruiting
Memorial Sloan Kettering Cancer Center - Monmouth Middletown New Jersey 07748 Not yet recruiting
Memorial Sloan Kettering Cancer Center - Bergen Montvale New Jersey 07645 Not yet recruiting
Memorial Sloan Kettering Cancer Center - Commack Commack New York 11725 Not yet recruiting
Memorial Sloan Kettering Cancer Center - Westchester East White Plains New York 10604 Not yet recruiting
Long Island Jewish Medical Center Lake Success New York 11042 Not yet recruiting
Perlmutter Cancer Center - 34th Street New York New York 10016 Not yet recruiting
Memorial Sloan Kettering Cancer Center - New York New York New York 10065 Recruiting
Memorial Sloan Kettering Cancer Center - Nassau Uniondale New York 11553 Not yet recruiting
Atrium Health Wake Forest Baptist - Comprehensive Cancer Center Charlotte North Carolina 28204 Not yet recruiting
Durham Veterans Affairs Health Care System Durham North Carolina 27705 Not yet recruiting
Gabrail Cancer and Research Center Canton Ohio 44718 Recruiting
Gibbs Cancer Center and Research Institute Spartanburg Spartanburg South Carolina 29303 Not yet recruiting
Virginia Cancer Specialists - Arlington Office Arlington Virginia 22201 Not yet recruiting
Virginia Cancer Specialists - Fairfax Office Fairfax Virginia 22031 Recruiting
Virginia Cancer Specialists - Bristow Office Manassas Virginia 20110 Not yet recruiting
Virginia Cancer Specialists - Reston Reston Virginia 20190 Not yet recruiting
Virginia Cancer Specialists - Woodbridge Office Woodbridge Virginia 22191 Not yet recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 223 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07128199, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Oct 13, 2026 · Synced Oct 17, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07128199 live on ClinicalTrials.gov.

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