A Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have Not Responded to or Who Cannot Tolerate Tumor Necrosis Factor (TNF) and/or Janus Kinase (JAK Inhibitors)
Public ClinicalTrials.gov record NCT07137598. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase II, Multicenter, Double-Blind, Placebo-Controlled Study to Assess the Efficacy and Safety of RO7790121 in Participants With Moderate to Severe Rheumatoid Arthritis Who Have an Inadequate Response or Intolerance to TNF and/or JAK Inhibitors
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study will assess the efficacy and safety of Afimkibart (also known as RO7790121) compared with placebo in participants with moderate to severe rheumatoid arthritis (RA) who have an inadequate response or intolerance to TNF and/or JAK inhibitors.
Study identification
- NCT ID
- NCT07137598
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 160 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 4, 2025
- Primary completion
- Apr 16, 2027
- Completion
- Oct 1, 2027
- Last update posted
- Aug 24, 2026
2025 – 2027
United States locations
- U.S. sites
- 16
- U.S. states
- 12
- U.S. cities
- 16
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| SunValley Arthritis Center Ltd. | Peoria | Arizona | 85381 | Recruiting |
| University of California Medical Center | La Jolla | California | 92037 | Recruiting |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | Recruiting |
| Inland Rheumatology Clinical Trials Incorporated | Upland | California | 91786 | Recruiting |
| West Broward Rheumatology Associates, Inc. | Tamarac | Florida | 33321 | Recruiting |
| Willow Rheumatology and Wellness PLLC | Willowbrook | Illinois | 60527 | Recruiting |
| Accurate Clinical Research Inc. | Lake Charles | Louisiana | 70605 | Recruiting |
| Henry Ford Medical Center- New Center One | Detroit | Michigan | 48202 | Recruiting |
| Equity Medical | The Bronx | New York | 10455 | Recruiting |
| Ohio State University Wexner Medical Center | Columbus | Ohio | 43203 | Recruiting |
| Altoona Center For Clinical Research | Duncansville | Pennsylvania | 16635 | Recruiting |
| Precision Comprehensive Clinical Research Solutions | Colleyville | Texas | 76034 | Recruiting |
| Accurate Clinical Management | Houston | Texas | 77089 | Recruiting |
| DM Clinical Research | Tomball | Texas | 77375 | Recruiting |
| Tidewater Clinical Research | Chesapeake | Virginia | 23320 | Recruiting |
| Rheumatic Disease Center | Glendale | Wisconsin | 53217 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 47 non-U.S. sites.
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About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07137598, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 24, 2026 · Synced Aug 29, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07137598 live on ClinicalTrials.gov.