OPI-NXYDLD-303 Safety and Efficacy of Phentolamine Ophthalmic Solution in Keratorefractive Surgery Participants With Decreased Mesopic Visual Acuity
Public ClinicalTrials.gov record NCT07140783. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
RANDOMIZED, PLACEBO-CONTROLLED, DOUBLE-MASKED STUDY OF THE SAFETY AND EFFICACY OF POS (0.75% PHENTOLAMINE OPHTHALMIC SOLUTION) IN PARTICIPANTS WITH PREVIOUS KERATOREFRACTIVE SURGERY WITH DECREASED VISUAL ACUITY UNDER MESOPIC CONDITIONS
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The goal of this clinical trial is to learn if Phentolamine Ophthalmic Solution works to treat adults that have had keratorefractive surgery and have decreased visual acuity under mesopic conditions. It will also learn about the safety of Phentolamine Ophthalmic Solution. The main questions it aims to answer are: Researchers will compare Phentolamine Ophthalmic Solution to a placebo (a look-alike substance that contains no drug) to see if Phentolamine Ophthalmic Solution works to improve vision in low light conditions. Participants will: Take Phentolamine Ophthalmic Solution or a placebo drop every day for 2 weeks Visit the clinic once every week for 2 weeks for checkups and tests Keep a diary of when they instill the study medication each evening
Study identification
- NCT ID
- NCT07140783
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 580 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 2, 2025 (Actual)
- Primary completion
- Aug 2027 (Estimated)
- Completion
- Aug 2027 (Estimated)
- Last update posted
- Oct 14, 2026
2025 – 2027
United States locations
- U.S. sites
- 20
- U.S. states
- 11
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Eye Care | Chandler | Arizona | 85224 | Recruiting |
| Eye Doctors of Arizona | Phoenix | Arizona | 85028 | Recruiting |
| MRB Eye Care Consultants | Scottsdale | Arizona | 85254 | Recruiting |
| Global Research Management | Glendale | California | 91204 | Recruiting |
| Gordon Schanzlin New Vision | La Jolla | California | 92037 | Recruiting |
| Eye Research Foundation | Newport Beach | California | 92663 | Recruiting |
| California Eye Specialists Medical Group | Pasadena | California | 91107 | Recruiting |
| NVISION Clinical Research | San Diego | California | 92117 | Recruiting |
| Scripps Poway Eyecare and Optometry | San Diego | California | 92130 | Recruiting |
| Wolsten and Goldberg Eye Assoc. | Torrance | California | 90505 | Recruiting |
| Segal Drug Trials | Delray Beach | Florida | 33484 | Recruiting |
| Wyse Eyecare | Northbrook | Illinois | 60062 | Recruiting |
| Virdi Eye Clinic | Rock Island | Illinois | 61201 | Recruiting |
| Kannarr Eye Care | Pittsburg | Kansas | 66762 | Recruiting |
| Northeast Eye Research Associates | Woburn | Massachusetts | 01801 | Recruiting |
| Oculus Research | Garner | North Carolina | 27529 | Recruiting |
| Scott & Christie EyeCare Associates | Cranberry Township | Pennsylvania | 16066 | Recruiting |
| West Bay Eye Assoc. | Warwick | Rhode Island | 02888 | Recruiting |
| Zillan Clinical Research | Houston | Texas | 77082 | Recruiting |
| Hoopes Vision | Draper | Utah | 84020 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07140783, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 14, 2026 · Synced Oct 21, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07140783 live on ClinicalTrials.gov.