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Active, not recruiting Phase 2 Interventional

A Study of SPY072 in Rheumatic Disease

ClinicalTrials.gov ID: NCT07148414

Public ClinicalTrials.gov record NCT07148414. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

ClinicalTrials.gov public records Last synced Oct 30, 2026, 6:39 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

Phase 2 Study to Assess the Efficacy and Safety of SPY002-072 in Adults With Moderately to Severely Active Rheumatologic Disease

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This is a multi-center, double-blind, placebo-controlled, Phase 2, proof-of-concept basket study with the goal of assessing the efficacy and safety of SPY072 compared to placebo in adults (aged ≥18 years) with rheumatic disease (RD).

Study identification

NCT ID
NCT07148414
Recruitment status
Active, not recruiting
Study type
Interventional
Phase
Phase 2
Lead sponsor
Spyre Therapeutics, Inc.
Industry
Enrollment
285 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Aug 21, 2025 (Actual)
Primary completion
Oct 31, 2026 (Estimated)
Completion
Mar 31, 2028 (Estimated)
Last update posted
Jun 5, 2026

2025 – 2028

United States locations

U.S. sites
18
U.S. states
7
U.S. cities
17
Facility City State ZIP Site status
Site 113 Avondale Arizona 85392 —
Site 118 Tucson Arizona 85748 —
Site 114 Chula Vista California 91910 —
Site 111 Covina California 91722 —
Site 108 Tujunga California 91042 —
Site 112 Upland California 91786 —
Site 107 Whittier California 90602 —
Site 115 Aventura Florida 33180 —
Site 109 Hialeah Florida 33016 —
Site 106 Ormond Beach Florida 32174 —
Site 110 Tampa Florida 33614 —
Site 116 Willowbrook Illinois 60527 —
Site 119 Rockville Maryland 20850 —
Site 104 Duncansville Pennsylvania 16635 —
Site 105 Corpus Christi Texas 78404 —
Site 120 Irving Texas 75039 —
Site 103 Tomball Texas 77375 —
Site 102 Tomball Texas 77377 —

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 46 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07148414, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jun 5, 2026 · Synced Oct 30, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07148414 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →