A Study of Orforglipron (LY3502970) in Participants With Obesity or Overweight and Osteoarthritis (OA) of the Knee
Public ClinicalTrials.gov record NCT07153471. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Study to Investigate the Efficacy and Safety of Orforglipron Once Daily in Participants Who Have Obesity or Overweight and Osteoarthritis of the Knee: A Multicenter, Randomized, Double-Blind, Parallel-Arm, Placebo-Controlled Trial
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The GZPT master protocol will support two independent studies, J2A-MC-GZT1 and J2A-MC-GZT2. Each study will see how well and safely orforglipron works in people with obesity or overweight who have osteoarthritis (OA) of the knee with pain. Participation in the study will last about 74 weeks.
Study identification
- NCT ID
- NCT07153471
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 800 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 15, 2025 (Actual)
- Primary completion
- Apr 2028 (Estimated)
- Completion
- May 2028 (Estimated)
- Last update posted
- Oct 8, 2026
2025 – 2028
United States locations
- U.S. sites
- 26
- U.S. states
- 17
- U.S. cities
- 25
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Arizona Research Center | Phoenix | Arizona | 85053 | — |
| AMR Clinical | Tempe | Arizona | 85281 | — |
| Care Access - Huntington Beach | Huntington Beach | California | 92648 | — |
| Care Access - Thousand Oaks | Thousand Oaks | California | 91360 | — |
| Legacy Clinical Trials | Colorado Springs | Colorado | 80909 | — |
| Chase Medical Research, LLC | Waterbury | Connecticut | 06708 | — |
| Care Access - Decatur | Decatur | Georgia | 30030 | — |
| North Georgia Clinical Research | Woodstock | Georgia | 30189 | — |
| Northwestern University | Chicago | Illinois | 60611 | — |
| AMR Clinical | Newton | Kansas | 67114 | — |
| MedVadis Research Corporation | Waltham | Massachusetts | 02451 | — |
| StudyMetrix Research | City of Saint Peters | Missouri | 63303 | — |
| AMR Clinical | Kansas City | Missouri | 64114 | — |
| Cardio Metabolic Institute | Somerset | New Jersey | 08873 | — |
| Carolina Research Center | Shelby | North Carolina | 28150 | — |
| University Orthopedics Center | Altoona | Pennsylvania | 16602 | — |
| Care Access - Rapid City | Rapid City | South Dakota | 57701 | — |
| AMR Clinical | Knoxville | Tennessee | 37909 | — |
| Mercy Family Clinic | Dallas | Texas | 75208 | — |
| Juno Research | Houston | Texas | 77040 | — |
| Biopharma Informatic, LLC | Houston | Texas | 77084 | — |
| Activian Clinical Research | Kingwood | Texas | 77339 | — |
| Advanced Rheumatology of Houston - Woodlands | The Woodlands | Texas | 77382 | — |
| Charlottesville Medical Research | Charlottesville | Virginia | 22911 | — |
| Gershon Pain Specialists | Virginia Beach | Virginia | 23454 | — |
| Northwest Clinical Research Center | Bellevue | Washington | 98007 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 62 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07153471, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 8, 2026 · Synced Oct 30, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07153471 live on ClinicalTrials.gov.