AV-1980R (Tau Vaccine) in Preclinical Alzheimer's Disease (TAURUS-1980)
Public ClinicalTrials.gov record NCT07158905. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase I, Randomized, Double-Blind Study to Evaluate the Safety and Tolerability of AV-1980R in Participants With Preclinical Alzheimer's Disease
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a Phase 1, multicenter, randomized, double-blind, placebo-controlled, multiple-dose-escalation study evaluating the safety, tolerability, and immunogenicity of AV-1980R, an investigational vaccine targeting pathological tau, in participants with preclinical Alzheimer's disease. Up to 48 cognitively unimpaired adults aged 65 to 80 years with biomarker evidence of preclinical Alzheimer's disease will be enrolled into three ascending-dose cohorts.
Study identification
- NCT ID
- NCT07158905
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 48 participants
Conditions and interventions
Conditions
Interventions
- AV-1980R 20 µg Biological
- AV-1980R 60 µg Biological
- AV-1980R 180 µg Biological
- Placebo Other
Biological · Other
Eligibility (public fields only)
- Age range
- 65 Years to 80 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Jun 22, 2026
- Primary completion
- Jun 14, 2029
- Completion
- Oct 14, 2029
- Last update posted
- Aug 20, 2026
2026 – 2029
United States locations
- U.S. sites
- 6
- U.S. states
- 2
- U.S. cities
- 6
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Comprehensive Center for Brain Health | Boca Raton | Florida | 33433 | Recruiting |
| Palm Springs Community Health Center | Miami Lakes | Florida | 33014 | Recruiting |
| Alzheimer's Research and Treatment Center (Stuart) | Stuart | Florida | 34996 | Recruiting |
| University of South Florida | Tampa | Florida | 33613 | Recruiting |
| Alzheimer's Research and Treatment Center (Wellington) | Wellington | Florida | 33414 | Recruiting |
| Alzheimer's Research and Treatment Center (Columbus) | Columbus | Georgia | 31904 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07158905, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 20, 2026 · Synced Sep 8, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07158905 live on ClinicalTrials.gov.