Phase 2a Study of VX-407 in Participants With ADPKD Who Have a Subset of PKD1 Gene Variants (AGLOW)
Public ClinicalTrials.gov record NCT07161037. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2a, Open-label, Single-arm Study to Evaluate the Efficacy, Safety, and Pharmacokinetics of VX-407 in Subjects With Autosomal Dominant Polycystic Kidney Disease Who Have a Subset of PKD1 Gene Variants
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of the study is to evaluate the effect of VX-407 on height-adjusted total kidney volume (htTKV), safety, tolerability, and pharmacokinetics (PK) of VX-407.
Study identification
- NCT ID
- NCT07161037
- Recruitment status
- Active, not recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 26 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years to 65 Years
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 18, 2025
- Primary completion
- Jul 21, 2027
- Completion
- Dec 30, 2027
- Last update posted
- Aug 10, 2026
2025 – 2027
United States locations
- U.S. sites
- 26
- U.S. states
- 18
- U.S. cities
- 24
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Alabama Kidney Research | Alabaster | Alabama | 35007 | — |
| UAB Nephrology Research at CH19 | Birmingham | Alabama | 35294 | — |
| Kaiser Permanente Los Angeles Medical Center | Los Angeles | California | 90027 | — |
| UCSF Clinical Research Center at Parnassus | San Francisco | California | 94143 | — |
| Nephrology & Hypertension Associates, PC | Middlebury | Connecticut | 06762 | — |
| Yale University - Yale Nephrology Clinical Research Clinic | New Haven | Connecticut | 06510 | — |
| Mayo Clinic - Jacksonville | Jacksonville | Florida | 32224 | — |
| Emory School of Medicine - Renal Division | Atlanta | Georgia | 30322 | — |
| Renal Associates | Columbus | Georgia | 31904 | — |
| UChicago Medicine - Duchossois Center for Advanced Medicine - Nephrology | Chicago | Illinois | 60637 | — |
| University of Iowa Health Care Medical Center- Nephrology | Iowa City | Iowa | 52242 | — |
| Clinical & Translational Science Unit (CTSU) - Nephrology | Kansas City | Kansas | 66160 | — |
| University of Maryland Medical Center - General Clinical Research Center | Baltimore | Maryland | 21201 | — |
| Tufts Medical Center | Boston | Massachusetts | 02111 | — |
| Beth Israel Deaconess Medical Center - Nephrology | Boston | Massachusetts | 02215 | — |
| University of Minnesota -Clinics and Surgery Center (CSC) - Endocrine Clinic | Minneapolis | Minnesota | 55455 | — |
| Mayo Clinic - Rochester | Rochester | Minnesota | 55905 | — |
| DaVita Kidney Care - Las Vegas | Las Vegas | Nevada | 89107 | — |
| The Rogosin Kidney Center | New York | New York | 10021 | — |
| General Nephrology Clinic - New York City | New York | New York | 10032 | — |
| Cleveland Clinic - Main Campus | Cleveland | Ohio | 44195 | — |
| Geisinger Clinic | Danville | Pennsylvania | 17822 | — |
| Perelman Center for Advanced Medicine - Nephrology | Philadelphia | Pennsylvania | 19104 | — |
| Nephrology Clinical Trials Center | Nashville | Tennessee | 37232 | — |
| UVM Medical Center - 1 South Prospect Street | Burlington | Vermont | 05401 | — |
| Swedish Center for Comprehensive Care | Seattle | Washington | 98104 | — |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07161037, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 10, 2026 · Synced Sep 6, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07161037 live on ClinicalTrials.gov.