A Study of ZW251 in Participants With Advanced Solid Tumors

ClinicalTrials.gov ID: NCT07164313

Public ClinicalTrials.gov record NCT07164313. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

View official ClinicalTrials.gov record → Back to search

ClinicalTrials.gov public records Last synced May 8, 2026, 4:47 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A First-In-Human, Phase 1, Open-Label, Multicenter Study of ZW251, a Novel Glypican-3 Targeting Antibody-Drug Conjugate, in Participants With Advanced Solid Tumors, Including Hepatocellular Carcinoma

Study identification

NCT ID: NCT07164313
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 1
Lead sponsor: Zymeworks BC Inc.; Industry
Enrollment: 100 participants

Conditions and interventions

Conditions

Interventions

ZW251 Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Oct 20, 2025
Primary completion: Aug 31, 2027
Completion: Apr 30, 2028
Last update posted: May 6, 2026

2025 – 2028

United States locations

U.S. sites: 8
U.S. states: 6
U.S. cities: 8

Facility	City	State	ZIP	Site status
UCSF Comprehensive Cancer Center	San Francisco	California	94158	Recruiting
University of California Los Angeles - Cancer Care - Santa Monica (UCLA)	Santa Monica	California	90404	Recruiting
Norton Cancer Institute	Louisville	Kentucky	40202	Recruiting
START Midwest	Grand Rapids	Michigan	49546	Recruiting
Hackensack University Medical Center	Hackensack	New Jersey	07601	Recruiting
Memorial Sloan Kettering Cancer Center	New York	New York	10065-6800	Recruiting
MD Anderson Cancer Center	Houston	Texas	77030	Recruiting
START San Antonio	San Antonio	Texas	78229	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 17 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07164313, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted May 6, 2026 · Synced May 8, 2026

Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07164313 live on ClinicalTrials.gov.

View official ClinicalTrials.gov record →