A Study of Pasritamig With or Without JNJ-87189401 Versus Placebo for Late Line Metastatic Castration-resistant Prostate Cancer (mCRPC)
Public ClinicalTrials.gov record NCT07164443. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized, Double-blind, Placebo-controlled Study of Pasritamig (JNJ-78278343), a T Cell Engaging Agent Targeting Human Kallikrein 2, With or Without JNJ-87189401, a PSMA-CD28 Costimulatory Agent, Plus Best Supportive Care Versus Best Supportive Care for Late-line Metastatic Castration-resistant Prostate Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the overall survival (length of time from the start of study to date of death from any cause) for pasritamig (JNJ-78278343) in Part 1 in combination with best supportive care (BSC) and in Part 2 with JNJ-87189401+BSC as compared to placebo with BSC in participants with metastatic castration-resistant prostate cancer (mCRPC; a stage of cancer that has spread beyond the prostate gland and is no longer responding to hormone therapies).
Study identification
- NCT ID
- NCT07164443
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 1,203 participants
Conditions and interventions
Interventions
- Pasritamig Biological
- Placebo Other
- Best Supportive Care (BSC) Drug
- JNJ-87189401 Biological
Biological · Other · Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Male
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 1, 2025
- Primary completion
- Aug 17, 2028
- Completion
- Aug 17, 2028
- Last update posted
- Aug 27, 2026
2025 – 2028
United States locations
- U.S. sites
- 54
- U.S. states
- 23
- U.S. cities
- 46
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of California at San Diego | La Jolla | California | 92093 | Recruiting |
| Cedars Sinai Medical Center | Los Angeles | California | 90048 | Recruiting |
| Ronald Reagan UCLA Medical Center | Los Angeles | California | 90095 | Recruiting |
| San Francisco VA Medical Center | San Francisco | California | 94121 | Recruiting |
| Rocky Mountain Cancer Centers | Aurora | Colorado | 80012 | Recruiting |
| University of Colorado Cancer Center | Aurora | Colorado | 80045 | Recruiting |
| Colorado Clinical Research | Lakewood | Colorado | 80228 | Recruiting |
| Hartford Hospital | Hartford | Connecticut | 06102 | Recruiting |
| Johns Hopkins Office of Capital Region Research - Sibley Memorial Hospital | Washington D.C. | District of Columbia | 20016 | Recruiting |
| Bay Pines VA Healthcare System | Bay Pines | Florida | 33744 | Recruiting |
| Florida Cancer Specialists & Research Institute | Fort Myers | Florida | 33901 | Recruiting |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Recruiting |
| University of Iowa Hospital and Clinics | Iowa City | Iowa | 52242 | Recruiting |
| Mission Cancer Blood | Waukee | Iowa | 50263 | Recruiting |
| East Jefferson General Hospital | Metairie | Louisiana | 70006 | Recruiting |
| Johns Hopkins University | Baltimore | Maryland | 21287 | Recruiting |
| Dana Farber Cancer Institute | Boston | Massachusetts | 02115 | Recruiting |
| University of Michigan Health System | Ann Arbor | Michigan | 48109 | Recruiting |
| Henry Ford Cancer Detroit | Detroit | Michigan | 48202 | Recruiting |
| University Of Minnesota Medical Center | Minneapolis | Minnesota | 55455 | Recruiting |
| XCancer Omaha / Urology Cancer Center | Omaha | Nebraska | 68130 | Recruiting |
| NYU Langone Hospitals | Brooklyn | New York | 11220 | Recruiting |
| NYU Langone Hospital Long Island | Mineola | New York | 11501 | Recruiting |
| NYU Langone Health Laura and Isaac Perlmutter Cancer Center | New York | New York | 10016 | Recruiting |
| Columbia University Medical Center | New York | New York | 10032 | Recruiting |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | Recruiting |
| Atrium Health Wake Forest Baptist Comprehensive Cancer Center | Winston-Salem | North Carolina | 27157 | Recruiting |
| University of Cincinnati | Cincinnati | Ohio | 45219 | Recruiting |
| University Hospital of Cleveland | Cleveland | Ohio | 44106 | Recruiting |
| Compass Oncology | Portland | Oregon | 97227 | Completed |
| VA Portland Health Care System | Portland | Oregon | 97239 | Recruiting |
| Oregon Urology Institute | Springfield | Oregon | 97477 | Recruiting |
| MidLantic Urology | Bala-Cynwyd | Pennsylvania | 19004 | Recruiting |
| Keystone Urology Specialists | Lancaster | Pennsylvania | 17601 | Recruiting |
| Penn Medicine Abramson Cancer Center | Philadelphia | Pennsylvania | 19104 | Recruiting |
| UPMC Cancer Centers | Pittsburgh | Pennsylvania | 15232 | Recruiting |
| Ralph H Johnson Veterans Hospital | Charleston | South Carolina | 29401 | Recruiting |
| Gibbs Cancer Center and Research Institute Pelham | Greer | South Carolina | 29650 | Recruiting |
| Carolina Urologic Research Center | Myrtle Beach | South Carolina | 29572 | Recruiting |
| Gibbs Cancer Center | Spartanburg | South Carolina | 29303 | Recruiting |
| Tennessee Oncology - Chattanooga | Chattanooga | Tennessee | 37404 | Recruiting |
| Tennessee Oncology Nashville | Nashville | Tennessee | 37203 | Recruiting |
| Urology Clinics of North Texas | Dallas | Texas | 75231 | Completed |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| MD Anderson Cancer Center | Houston | Texas | 77030 | Recruiting |
| Michael E DeBakey VA Medical Center | Houston | Texas | 77030 | Recruiting |
| Texas Oncology West Texas | Wichita Falls | Texas | 76310 | Recruiting |
| Utah Cancer Specialists | Salt Lake City | Utah | 84106 | Recruiting |
| Virginia Cancer Specialists | Fairfax | Virginia | 22031 | Recruiting |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | Recruiting |
| Blue Ridge Cancer Care | Roanoke | Virginia | 24014 | Recruiting |
| VA Puget Sound Healthcare System | Seattle | Washington | 98108 | Recruiting |
| Fred Hutchinson Cancer Research Center | Seattle | Washington | 98109 | Recruiting |
| University of Washington | Seattle | Washington | 98195 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 119 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07164443, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 27, 2026 · Synced Sep 9, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07164443 live on ClinicalTrials.gov.