Study to Assess the Efficacy and Safety of Rina-S Compared to Treatment of Investigator's Choice in Participants With Endometrial Cancer
Public ClinicalTrials.gov record NCT07166094. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3 Randomized, Open-label Study of Rinatabart Sesutecan (Rina-S) Versus Treatment of Investigator's Choice (IC) in Patients With Endometrial Cancer After Platinum-Based Chemotherapy and PD(L)-1 Therapy
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to compare how well Rina-S (GEN1184) works compared to treatment of physician's choice (paclitaxel or doxorubicin) that are considered standard medical care for the treatment of recurrent or progressive endometrial cancer (EC) following prior therapy. There is an equal (50:50) chance of getting either Rina-S or a chemotherapy agent as treatment in this study. The study duration will be approximately 3 years. The treatment duration will be different for every participant, but an average of 4 to 6 months is expected. All participants will receive active drug; no one will be given placebo. Participation in the study will require visits to the study site(s).
Study identification
- NCT ID
- NCT07166094
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 660 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- Female
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 27, 2025
- Primary completion
- Jul 31, 2029
- Completion
- Oct 31, 2029
- Last update posted
- Sep 8, 2026
2025 – 2029
United States locations
- U.S. sites
- 68
- U.S. states
- 22
- U.S. cities
- 53
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| USAH Mitchell Cancer Inst | Mobile | Alabama | 36604 | Recruiting |
| HonorHealth Research Inst | Phoenix | Arizona | 85016 | Recruiting |
| Kaiser Permanente SoCal | Irvine | California | 92618 | Recruiting |
| CPMC Research Institute | San Francisco | California | 94109 | Recruiting |
| Norwalk Hospital | Danbury | Connecticut | 06810 | Recruiting |
| Hartford Hospital | Hartford | Connecticut | 06102 | Recruiting |
| Norwalk Hospital | Norwalk | Connecticut | 06856 | Recruiting |
| MedStar Washington Hospital | Washington D.C. | District of Columbia | 20010 | Recruiting |
| SMH - Sarasota - Main Campus | Sarasota | Florida | 34239 | Recruiting |
| Women's Care - 9th Ave | St. Petersburg | Florida | 33713 | Recruiting |
| Women's Care - Armenia Ave | Tampa | Florida | 33603 | Recruiting |
| Emory Winship Cancer Inst. | Atlanta | Georgia | 30308 | Recruiting |
| Emory Winship Cancer Inst. | Atlanta | Georgia | 30322 | Recruiting |
| Northside Hospital Atlanta | Atlanta | Georgia | 30342 | Recruiting |
| Emory Winship Cancer Inst./Emory Decatur Hospital | Decatur | Georgia | 30033 | Recruiting |
| Endeavor Health NorthShore | Evanston | Illinois | 60201 | Recruiting |
| OLOL Cancer Institute | Baton Rouge | Louisiana | 70808 | Recruiting |
| Trials365, LLC | Shreveport | Louisiana | 71103 | Recruiting |
| Sinai Hospital | Baltimore | Maryland | 21215 | Recruiting |
| William Kahlert Reg. Can. Ctr | Westminster | Maryland | 21157 | Recruiting |
| UMass Memorial Medical Ctr | Worcester | Massachusetts | 01605 | Recruiting |
| Corewell Health | Grand Rapids | Michigan | 49503 | Recruiting |
| USOR - Minnesota Oncology-Coon Rapids Clinic | Coon Rapids | Minnesota | 55433 | Recruiting |
| USOR - Minnesota Oncology/ Coon Rapids Clinic | Coon Rapids | Minnesota | 55433 | Recruiting |
| USOR - Minnesota Oncology - Edina Clinic | Edina | Minnesota | 55435 | Recruiting |
| USOR - Minnesota Oncology/Edina Clinic | Edina | Minnesota | 55435 | Recruiting |
| USOR - Minnesota Oncology/ Maple Grove Clinic | Maple Grove | Minnesota | 55369 | Recruiting |
| USOR - Minnesota Oncology-Maplewood Clinic | Maplewood | Minnesota | 55109 | Recruiting |
| USOR - Minnesota Oncology/ Maplewood Clinic | Maplewood | Minnesota | 55109 | Recruiting |
| USOR - Minnesota Oncology/ Minneapolis Clinic | Minneapolis | Minnesota | 55404 | Recruiting |
| USOR - Minnesota Oncology | Minneapolis | Minnesota | 55404 | Recruiting |
| USOR - Minnesota Oncology/ Woodbury Clinic | Woodbury | Minnesota | 55125 | Recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63110 | Recruiting |
| Morristown Medical Center | Morristown | New Jersey | 07960 | Recruiting |
| Atlantic Health - Overlook MC | Summit | New Jersey | 07901 | Recruiting |
| Holy Name Medical Center | Teaneck | New Jersey | 07666 | Recruiting |
| NYU Laura and Isaac Perlmutter Cancer Center - 34th Street | New York | New York | 10016 | Recruiting |
| Perlmutter CC NYU Langone LI | New York | New York | 11501 | Recruiting |
| Atrium Health LCI - Morehead | Charlotte | North Carolina | 28204 | Recruiting |
| Atrium Health LCI - Ballantyne | Charlotte | North Carolina | 28277 | Recruiting |
| Atrium Health LCI - Concord | Concord | North Carolina | 28025 | Recruiting |
| Duke Cancer Institute | Durham | North Carolina | 27710 | Recruiting |
| Atrium Health LCI - Gaston | Gastonia | North Carolina | 28054 | Recruiting |
| Wake Forest University | Winston-Salem | North Carolina | 27517 | Recruiting |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | Recruiting |
| Willamette Valley Cancer Institute and Research Center - Eugene | Eugene | Oregon | 97401 | Recruiting |
| NW Cancer Specs. P.C. | Happy Valley | Oregon | 97015 | Recruiting |
| USOR - NW Cancer Specs P.C. | Portland | Oregon | 97227 | Recruiting |
| USOR - NW Cancer Specs. P.C. | Tigard | Oregon | 97223 | Recruiting |
| TX Onc - Arlington North | Arlington | Texas | 76012 | Recruiting |
| USOR - Texas Oncology | Austin | Texas | 78731 | Recruiting |
| USOR - Texas Oncology | Austin | Texas | 78745 | Recruiting |
| USOR - Texas Oncology- Austin North | Austin | Texas | 78758 | Recruiting |
| TX Onc - Bedford | Bedford | Texas | 76022 | Recruiting |
| TX Onc - Methodist Dallas | Dallas | Texas | 75203 | Recruiting |
| TX Onc - Presbyterian Dallas | Dallas | Texas | 75231 | Recruiting |
| TX Onc - Methodist Charlton | Dallas | Texas | 75237 | Recruiting |
| TX Onc - Sammons | Dallas | Texas | 75246 | Recruiting |
| USOR - Texas Oncology - Dallas Fort Worth (DFW) | Fort Worth | Texas | 76104 | Recruiting |
| USOR - Texas Oncology | Harlingen | Texas | 78550 | Recruiting |
| USOR - Texas Oncology | McAllen | Texas | 78503 | Recruiting |
| USOR - TX Oncology - SA NE | San Antonio | Texas | 78217 | Recruiting |
| NEXT San Antonio | San Antonio | Texas | 78240 | Recruiting |
| USOR - Texas Oncology- Horizon Circle | Waco | Texas | 76712 | Recruiting |
| USOR - Texas Oncology- Waco | Waco | Texas | 76712 | Recruiting |
| USOR - Texas Oncology | Weslaco | Texas | 78596 | Recruiting |
| University of Virginia | Charlottesville | Virginia | 22908 | Recruiting |
| USOR - NW Cancer Specs P.C. | Vancouver | Washington | 98684 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 103 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07166094, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 8, 2026 · Synced Sep 26, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07166094 live on ClinicalTrials.gov.