Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
Public ClinicalTrials.gov record NCT07175428. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Multicenter, Open-label, Blinded-endpoint Study to Evaluate the Safety of REGN7508 and REGN9933, Monoclonal Antibodies Against FXI, Versus Apixaban in Participants With Atrial Fibrillation (ROXI-ATLAS)
Study identification
- NCT ID
- NCT07175428
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Lead sponsor
- Regeneron Pharmaceuticals
- Industry
- Enrollment
- 1,200 participants
Conditions and interventions
Conditions
Interventions
- Apixaban Drug
- REGN7508 Drug
- REGN9933 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 19, 2025
- Primary completion
- Feb 8, 2027
- Completion
- Apr 20, 2027
- Last update posted
- May 10, 2026
2025 – 2027
United States locations
- U.S. sites
- 35
- U.S. states
- 15
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| SEC Clinical Research | Dothan | Alabama | 36305 | Recruiting |
| Eastern Shore Research Institute | Fairhope | Alabama | 36532 | Recruiting |
| Mission Cardiovascular Research Institute | Fremont | California | 94538 | Recruiting |
| National Institute of California Heart and Vein Specialists | Huntington Beach | California | 92648 | Recruiting |
| Profound Research LLC at Southern California Heart Specialists | Pasadena | California | 91105 | Recruiting |
| Empire Clinical Research | Pomona | California | 91767 | Recruiting |
| Northbay Clinical Research Center | Santa Rosa | California | 95405 | Recruiting |
| Cardiology Associates Medical Group | Ventura | California | 93003 | Recruiting |
| Interventional Cardiology Medical Group | West Hills | California | 91307 | Recruiting |
| Nouvelle Clinical Research LLC | Cutler Bay | Florida | 33189 | Recruiting |
| Inpatient Research Clinic LLC | Miami Lakes | Florida | 33014 | Recruiting |
| Cardiovascular Center of Sarasota Foundation for Research and Education | Sarasota | Florida | 34239 | Recruiting |
| Clinical Site Partners, LLC DBA Flourish Research | Winter Park | Florida | 32789 | Recruiting |
| Health Sciences Research Building II | Atlanta | Georgia | 30322 | Recruiting |
| NSC Research, Inc | Johns Creek | Georgia | 30024 | Recruiting |
| Indiana University | Indianapolis | Indiana | 46202 | Recruiting |
| Blue Coast Research Center, LLC | Indianapolis | Indiana | 46237 | Recruiting |
| Franciscan Physician Network, Indiana Heart Physicians | Indianapolis | Indiana | 46237 | Recruiting |
| Indiana Medical Research | Merrillville | Indiana | 46410 | Recruiting |
| Reid Physician Associates | Richmond | Indiana | 47374 | Recruiting |
| Monroe Research, LLC | West Monroe | Louisiana | 71291 | Recruiting |
| Anderson Medical Research | Ft. Washington | Maryland | 20744 | Recruiting |
| Beth Israel Lahey Health, Beth Israel Deaconess Medical Center (BIDMC) | Boston | Massachusetts | 02215 | Recruiting |
| Profound Research LLC | Farmington Hills | Michigan | 48334 | Recruiting |
| AA Medical Research Center (MRC) | Flint | Michigan | 48504 | Recruiting |
| Moses Cone Hospital Operating Corporation dba Cone Health, Lebauer-Brodie Center for Cardiovascular Research | Greensboro | North Carolina | 27401 | Recruiting |
| K&R Research LLC | Marion | Ohio | 43302 | Recruiting |
| Advanced Medical Research | Maumee | Ohio | 43537 | Recruiting |
| Monument Health Clinical Research | Rapid City | South Dakota | 57701 | Recruiting |
| East Coast Institute for Research, Jefferson City | Jefferson City | Tennessee | 37760 | Recruiting |
| PharmaTex Research | Amarillo | Texas | 79106 | Recruiting |
| Complete Heart Care P.A. | McKinney | Texas | 75071 | Recruiting |
| Permian Research Foundation | Odessa | Texas | 79761 | Recruiting |
| Tyler Cardiovascular Consultants | Tyler | Texas | 75701 | Recruiting |
| Alpine Research TC | Clinton | Utah | 84015 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 10 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07175428, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 10, 2026 · Synced May 19, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07175428 live on ClinicalTrials.gov.