Safety in Adult Participants With Atrial Fibrillation Who Are Treated With Anticoagulation
Public ClinicalTrials.gov record NCT07175428. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2, Randomized, Multicenter, Open-label, Blinded-endpoint Study to Evaluate the Safety of REGN7508 and REGN9933, Monoclonal Antibodies Against FXI, Versus Apixaban in Participants With Atrial Fibrillation (ROXI-ATLAS)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is researching experimental drugs called REGN7508 and REGN9933. The study is focused on participants who have atrial fibrillation, which means that the heart beats too fast and unevenly. REGN7508 and REGN9933 are designed to help stop blood clots forming in patients with atrial fibrillation. The aim of the study is to see how well REGN7508 and REGN9933 work in patients that get medicine for their atrial fibrillation. The bleeding effects of REGN7508 and REGN9933 will be compared to another medicine (apixaban), which is available on the market to treat and prevent formation of blood clots. The study is looking at several other research questions, including: * What side effects may happen from taking REGN7508 or REGN9933 * How well do the study drugs reduce the risk of having a stroke * How much of REGN7508 or REGN9933 is in the blood at different times * Whether the body makes antibodies against REGN7508 or REGN9933 (which could make the drugs less effective or could lead to side effects)
Study identification
- NCT ID
- NCT07175428
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 1,200 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 19, 2025
- Primary completion
- Feb 8, 2027
- Completion
- Apr 20, 2027
- Last update posted
- Aug 19, 2026
2025 – 2027
United States locations
- U.S. sites
- 43
- U.S. states
- 16
- U.S. cities
- 39
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| SEC Clinical Research | Dothan | Alabama | 36305 | Recruiting |
| Eastern Shore Research Institute | Fairhope | Alabama | 36532 | Recruiting |
| Valley Clinical Trials, Inc | Covina | California | 91723 | Recruiting |
| North Coast Cardiology | Encinitas | California | 92024 | Recruiting |
| Mission Cardiovascular Research Institute | Fremont | California | 94538 | Recruiting |
| National Institute of California Heart and Vein Specialists | Huntington Beach | California | 92648 | Recruiting |
| Profound Research LLC at Southern California Heart Specialists | Pasadena | California | 91105 | Recruiting |
| Empire Clinical Research | Pomona | California | 91767 | Recruiting |
| The Cardiovascular Center | Redding | California | 96001 | Recruiting |
| Northbay Clinical Research Center | Santa Rosa | California | 95405 | Recruiting |
| Cardiology Associates Medical Group | Ventura | California | 93003 | Recruiting |
| Interventional Cardiology Medical Group | West Hills | California | 91307 | Recruiting |
| Nouvelle Clinical Research LLC | Cutler Bay | Florida | 33189 | Recruiting |
| South Florida Research Organization LLC | Medley | Florida | 33166 | Recruiting |
| Inpatient Research Clinic LLC | Miami Lakes | Florida | 33014 | Recruiting |
| Cardiovascular Center of Sarasota Foundation for Research and Education | Sarasota | Florida | 34239 | Recruiting |
| Clinical Site Partners, LLC DBA Flourish Research | Winter Park | Florida | 32789 | Recruiting |
| Grady Health System | Atlanta | Georgia | 30303 | Recruiting |
| Health Sciences Research Building II | Atlanta | Georgia | 30322 | Withdrawn |
| NSC Research, Inc | Johns Creek | Georgia | 30024 | Recruiting |
| Indiana University | Indianapolis | Indiana | 46202 | Recruiting |
| Blue Coast Research Center, LLC | Indianapolis | Indiana | 46237 | Recruiting |
| Franciscan Physician Network, Indiana Heart Physicians | Indianapolis | Indiana | 46237 | Recruiting |
| Indiana Medical Research | Merrillville | Indiana | 46410 | Recruiting |
| Reid Physician Associates | Richmond | Indiana | 47374 | Recruiting |
| Monroe Research, LLC | West Monroe | Louisiana | 71291 | Recruiting |
| Anderson Medical Research | Ft. Washington | Maryland | 20744 | Recruiting |
| Beth Israel Lahey Health, Beth Israel Deaconess Medical Center (BIDMC) | Boston | Massachusetts | 02215 | Recruiting |
| Profound Research, Millennium Cardiology | Farmington Hills | Michigan | 48334 | Recruiting |
| AA Medical Research Center (MRC) | Flint | Michigan | 48504 | Recruiting |
| Fairview Health Services | Maplewood | Minnesota | 55109 | Recruiting |
| Moses Cone Hospital Operating Corporation dba Cone Health, Lebauer-Brodie Center for Cardiovascular Research | Greensboro | North Carolina | 27401 | Recruiting |
| K&R Research LLC | Marion | Ohio | 43302 | Recruiting |
| Advanced Medical Research | Maumee | Ohio | 43537 | Recruiting |
| Monument Health Clinical Research | Rapid City | South Dakota | 57701 | Recruiting |
| East Coast Institute for Research, Jefferson City | Jefferson City | Tennessee | 37760 | Recruiting |
| PharmaTex Research | Amarillo | Texas | 79106 | Recruiting |
| Complete Heart Care P.A. | McKinney | Texas | 75071 | Recruiting |
| Texas Institute of Cardiology PA | McKinney | Texas | 75071 | Recruiting |
| Synergy Group Medical, LLC | Missouri City | Texas | 77459 | Recruiting |
| Permian Research Foundation | Odessa | Texas | 79761 | Recruiting |
| Tyler Cardiovascular Consultants | Tyler | Texas | 75701 | Recruiting |
| Alpine Research TC | Clinton | Utah | 84015 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 34 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07175428, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 19, 2026 · Synced Sep 10, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07175428 live on ClinicalTrials.gov.