Metastatic Ewing's Trial Testing Schedule Enhancement to Improve Outcomes
Public ClinicalTrials.gov record NCT07194044. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This single arm study is designed to demonstrate the feasibility of a radically different approach for an exceptionally high-risk subset of MES with widely metastatic disease (WMES). We incorporate the use of evolutionary principles that apply to species and population dynamics as related to adaptation and extinction to populations of cancer cells that similarly adapt and that we are attempting to make extinct, resulting in a cure for the patient. Such principles include an initial intense first strike to deplete the bulk of the cancer cells, followed by a series of sequential second strikes towards eliminating residual, resistant populations, followed by a prolonged period of maintenance chemotherapy to eliminate any remnant cells, using agents generally regarded to be active against newly diagnosed ES.
Study identification
- NCT ID
- NCT07194044
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1
- Enrollment
- 15 participants
Conditions and interventions
Conditions
Interventions
- Vincristine Drug
- Doxorubicin Drug
- Cyclophosphamide Drug
- Ifosfamide Drug
- Actinomycin Drug
- Irinotecan Drug
- Cabozantinib Drug
- Topotecan Drug
- Temozolomide Drug
- Etoposide Drug
- Liposomal doxorubicin Drug
Drug
Eligibility (public fields only)
- Age range
- 1 Year and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Feb 4, 2026
- Primary completion
- Sep 30, 2030
- Completion
- Sep 30, 2030
- Last update posted
- Aug 27, 2026
2026 – 2030
United States locations
- U.S. sites
- 20
- U.S. states
- 11
- U.S. cities
- 19
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| University of Alabama at Birmingham (Children's of Alabama) | Birmingham | Alabama | 35233 | Recruiting |
| Phoenix Children's Hospital | Phoenix | Arizona | 85016 | Recruiting |
| Connecticut Children's Medical Center | Hartford | Connecticut | 06106 | Not yet recruiting |
| University of Florida | Gainesville | Florida | 32610 | Recruiting |
| Nemours Jacksonville | Jacksonville | Florida | 32207 | Not yet recruiting |
| University of Miami | Miami | Florida | 33136 | Recruiting |
| Johns Hopkins All Children's Hospital | St. Petersburg | Florida | 33701 | Recruiting |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Recruiting |
| University of Kentucky | Lexington | Kentucky | 40536 | Not yet recruiting |
| Helen DeVos Children's Hospital | Grand Rapids | Michigan | 49503 | Not yet recruiting |
| Roswell Park Comprehensive Cancer Center | Buffalo | New York | 14263 | Not yet recruiting |
| Montefiore Medical Center | The Bronx | New York | 10467 | Recruiting |
| University of North Carolina | Chapel Hill | North Carolina | 27599 | Not yet recruiting |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | Not yet recruiting |
| Duke University Medical Center- Children's Health Center | Durham | North Carolina | 27710 | Recruiting |
| Cleveland Clinic Children's | Cleveland | Ohio | 44195 | Not yet recruiting |
| Nationwide Children's Hospital | Columbus | Ohio | 43205 | Recruiting |
| Monroe Carell Jr. Children's Hospital at Vanderbilt | Nashville | Tennessee | 37232 | Recruiting |
| Vanderbilt University Medical Center | Nashville | Tennessee | 37232 | Recruiting |
| Primary Children's Hospital | Salt Lake City | Utah | 84113 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07194044, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 27, 2026 · Synced Sep 15, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07194044 live on ClinicalTrials.gov.