A Dose-masked Study of Intravitreal EYE103 in Participants With NVAMD or Macular Edema Following BRVO
Public ClinicalTrials.gov record NCT07205887. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 2 Randomized, Dose-Masked Study of Intravitreal EYE103 in Participants With Neovascular Age-Related Macular Degeneration (NVAMD) or Macular Edema Following Branch Retinal Vein Occlusion (BRVO)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
EYE-RES-104 is a randomized, dose-masked study of intravitreal EYE103 in participants with neovascular age-related macular degeneration (NVAMD) or macular edema following branch retinal vein occlusion (BRVO). The study will consist of 4 patient cohorts, with participants in each cohort randomized (1:1) to either a low dose of EYE103 via IVT or a high dose of EYE103 via IVT. 40 participants will be enrolled in each cohort. Enrollment timing for each cohort will be sequenced into specific arms of the study at the Sponsor's discretion. All participants in the study will receive a total of 3 injections of EYE103 into the study eye, spaced at 4 weeks apart. All participants will return at designated time points following each injection for safety and efficacy assessments. The Week 12 Visit will serve as the end of study visit for all participants.
Study identification
- NCT ID
- NCT07205887
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2
- Enrollment
- 160 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Sep 11, 2025
- Primary completion
- Jun 29, 2028
- Completion
- Jun 29, 2028
- Last update posted
- Sep 3, 2026
2025 – 2028
United States locations
- U.S. sites
- 55
- U.S. states
- 15
- U.S. cities
- 37
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Scottsdale, Arizona | Scottsdale | Arizona | 85255 | Recruiting |
| Scottsdale, AZ | Scottsdale | Arizona | 85255 | Recruiting |
| Glendale, California | Glendale | California | 91204 | Recruiting |
| Glendale, CA | Glendale | California | 91204 | Recruiting |
| Modesto, California | Modesto | California | 95356 | Recruiting |
| Mountain View, California | Mountain View | California | 94040 | Recruiting |
| Sacramento, CA | Sacramento | California | 95825 | Recruiting |
| Sactamento, California | Sacramento | California | 95825 | Recruiting |
| Sacramento, California | Sacramento | California | 95841 | Recruiting |
| Santa Ana, California | Santa Ana | California | 92705 | Recruiting |
| RSC Research LLC | Denver | Colorado | 80222 | Recruiting |
| Fort Lauderdale, Florida | Fort Lauderdale | Florida | 33308 | Recruiting |
| Fort Lauderdale, FL | Fort Lauderdale | Florida | 33308 | Recruiting |
| Florida Retina Institute | Jacksonville | Florida | 32216 | Recruiting |
| Florida Retina Institute | Orlando | Florida | 32806 | Recruiting |
| Lemont, Illinois | Lemont | Illinois | 60439 | Recruiting |
| Lemont, IL | Lemont | Illinois | 60439 | Recruiting |
| Hagerstown, Maryland | Hagerstown | Maryland | 21740 | Recruiting |
| Hagerstown, MD | Hagerstown | Maryland | 21740 | Recruiting |
| Madison, Mississippi | Madison | Mississippi | 39110 | Recruiting |
| Madison, MS | Madison | Mississippi | 39110 | Recruiting |
| Bloomfield, New Jersey | Bloomfield | New Jersey | 07003 | Recruiting |
| Bloomfield, NJ | Bloomfield | New Jersey | 07003 | Recruiting |
| Long Island Vitreoretinal Consultants of NY | Great Neck | New York | 11021 | Recruiting |
| Asheville, North Carolina | Asheville | North Carolina | 28803 | Recruiting |
| Cary, North Carolina | Cary | North Carolina | 27511 | Recruiting |
| North Carolina Retina Associates | Greenville | North Carolina | 27834 | Recruiting |
| Wake Forest, NC | Wake Forest | North Carolina | 27587 | Recruiting |
| Wake Forest, North Carolina | Wake Forest | North Carolina | 27587 | Recruiting |
| West Columbia, SC | West Columbia | South Carolina | 29169 | Recruiting |
| West Columbia, South Carolina | West Columbia | South Carolina | 29169 | Recruiting |
| Germantown, Tennessee | Germantown | Tennessee | 38138 | Recruiting |
| Knoxville, Tennessee | Knoxville | Tennessee | 37922 | Recruiting |
| Nashville, Tennessee | Nashville | Tennessee | 37203 | Recruiting |
| Nashville, TN | Nashville | Tennessee | 37203 | Recruiting |
| Abilene, Texas | Abilene | Texas | 79606 | Recruiting |
| Amarillo, Texas | Amarillo | Texas | 79106 | Recruiting |
| Austin, Texas | Austin | Texas | 78705 | Recruiting |
| Austin, TX | Austin | Texas | 78705 | Recruiting |
| Bellaire, Texas | Bellaire | Texas | 77401 | Recruiting |
| Bellaire, TX | Bellaire | Texas | 77401 | Recruiting |
| Burleson, Texas | Burleson | Texas | 76028 | Recruiting |
| Dallas, Texas | Dallas | Texas | 75231 | Recruiting |
| Dallas, TX | Dallas | Texas | 75231 | Recruiting |
| Plano, Texas | Plano | Texas | 75075 | Recruiting |
| Round Rock, TX | Round Rock | Texas | 78681 | Recruiting |
| Round Rock, Texas | Round Rock | Texas | 78781 | Recruiting |
| San Antonio, Texas | San Antonio | Texas | 78240 | Recruiting |
| San Antonio, TX | San Antonio | Texas | 78240 | Recruiting |
| San Marcos, Texas | San Marcos | Texas | 78666 | Recruiting |
| The Woodlands, Texas | The Woodlands | Texas | 77384 | Recruiting |
| The Woodlands, TX | The Woodlands | Texas | 77384 | Recruiting |
| Willow Park, Texas | Willow Park | Texas | 76087 | Recruiting |
| West Jordan, Utah | West Jordan | Utah | 84088 | Recruiting |
| Retina Consultants, PLLC | Charleston | West Virginia | 25301 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07205887, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Sep 3, 2026 · Synced Sep 16, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07205887 live on ClinicalTrials.gov.