REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants

ClinicalTrials.gov ID: NCT07213778

Public ClinicalTrials.gov record NCT07213778. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 5, 2026, 4:24 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Multicenter, Double-Blinded, Randomized Study to Evaluate REGN7508, a Factor XI Monoclonal Antibody, Versus Acetylsalicylic Acid for Prophylaxis of Symptomatic Venous Thromboembolism After Elective Total Knee Arthroplasty (ROXI-ASPEN)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study is researching an experimental drug called REGN7508 (called "study drug") and how it compares against another treatment called Acetylsalicylic Acid (ASA). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing Venous Thromboembolism (VTE) and other related diseases after total knee replacement surgery compared to acetylsalicylic acid. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)

Study identification

NCT ID: NCT07213778
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Regeneron Pharmaceuticals; Industry
Enrollment: 2,000 participants

Conditions and interventions

Conditions

Symptomatic Venous Thromboembolism (VTE)

Interventions

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Nov 23, 2025
Primary completion: May 16, 2027
Completion: Jul 15, 2027
Last update posted: Aug 18, 2026

2025 – 2027

United States locations

U.S. sites: 29
U.S. states: 16
U.S. cities: 24

Facility	City	State	ZIP	Site status
Horizon Clinical Research	La Mesa	California	91942	Recruiting
Eisenhower Medical Center	Rancho Mirage	California	92270	Recruiting
Sky Ridge Medical Center	Lone Tree	Colorado	80124	Recruiting
South Florida Joint Replacement Center	Deerfield Beach	Florida	33064	Recruiting
Medical Research of Westchester - MPLUS Research Network	Miami	Florida	33165	Recruiting
Larkin Community Hospital South Miami	South Miami	Florida	33143	Recruiting
Phoenix Clinical Research	Tamarac	Florida	33321	Recruiting
Endeavor Health	Skokie	Illinois	60076	Recruiting
The Orthopaedic Research Foundation, Inc.	Indianapolis	Indiana	46278	Recruiting
NextStage Clinical Research, St. Francis Medical Park	Wichita	Kansas	67214	Recruiting
Velocity Clinical Research, Annapolis	Annapolis	Maryland	21401	Recruiting
Sinai Hospital of Baltimore, Inc.	Baltimore	Maryland	21215	Recruiting
Tufts Medical Center	Boston	Massachusetts	02111	Recruiting
Boston Medical Center	Boston	Massachusetts	02118	Recruiting
Holy Name Medical Center	Teaneck	New Jersey	07666	Recruiting
University of Rochester Medical Center	Rochester	New York	14623-5863	Recruiting
Eximia Equihealth Research-Raleigh. LLC	Raleigh	North Carolina	27612	Recruiting
The Vein and Vascular Center at Raleigh Radiology	Raleigh	North Carolina	27612	Recruiting
Coastal Vascular Institute, PA	Wilmington	North Carolina	28401	Recruiting
University of Cincinnati	Cincinnati	Ohio	45267	Recruiting
The Ohio State University Wexner Medical Center	Columbus	Ohio	43210	Recruiting
Ohio Clinical Trials	Columbus	Ohio	43212	Recruiting
University of Pittsburgh	Pittsburgh	Pennsylvania	15213-3108	Recruiting
HD Research - Memorial Hermann Village	Houston	Texas	77043	Recruiting
NextStage Clinical Research, All American Orthopedics and Sports Medicine	Houston	Texas	77058	Recruiting
Flourish Research - San Antonio (Formerly Clinical Trials of Texas)	San Antonio	Texas	78229	Recruiting
Endeavor Clinical Trials	San Antonio	Texas	78240	Withdrawn
Carilion Clinic	Roanoke	Virginia	24015	Recruiting
Spokane Joint Replacement Center	Spokane	Washington	99218	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 5 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07213778, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Aug 18, 2026 · Synced Sep 5, 2026

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The complete protocol, eligibility criteria, and contact information for NCT07213778 live on ClinicalTrials.gov.

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