REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants
Public ClinicalTrials.gov record NCT07213778. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Double-Blinded, Randomized Study to Evaluate REGN7508, a Factor XI Monoclonal Antibody, Versus Acetylsalicylic Acid for Prophylaxis of Symptomatic Venous Thromboembolism After Elective Total Knee Arthroplasty (ROXI-ASPEN)
Study identification
- NCT ID
- NCT07213778
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Regeneron Pharmaceuticals
- Industry
- Enrollment
- 2,000 participants
Conditions and interventions
Conditions
Interventions
- Acetylsalicylic Acid (ASA) Drug
- Placebo Drug
- REGN7508 Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 23, 2025
- Primary completion
- May 16, 2027
- Completion
- Jul 15, 2027
- Last update posted
- May 5, 2026
2025 – 2027
United States locations
- U.S. sites
- 16
- U.S. states
- 12
- U.S. cities
- 15
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Eisenhower Medical Center | Rancho Mirage | California | 92270 | Recruiting |
| Sky Ridge Medical Center | Lone Tree | Colorado | 80124 | Recruiting |
| Medical Research of Westchester - MPLUS Research Network | Miami | Florida | 33165 | Recruiting |
| Phoenix Clinical Research | Tamarac | Florida | 33321 | Recruiting |
| Endeavor Health | Skokie | Illinois | 60076 | Recruiting |
| The Orthopaedic Research Foundation, Inc. | Indianapolis | Indiana | 46278 | Recruiting |
| NextStage Clinical Research, St. Francis Medical Park | Wichita | Kansas | 67214 | Recruiting |
| Sinai Hospital of Baltimore, Inc. | Baltimore | Maryland | 21215 | Recruiting |
| Holy Name Medical Center | Teaneck | New Jersey | 07666 | Recruiting |
| Coastal Vascular Institute, PA | Wilmington | North Carolina | 28401 | Recruiting |
| University of Cincinnati | Cincinnati | Ohio | 45267 | Recruiting |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | Recruiting |
| Ohio Clinical Trials | Columbus | Ohio | 43212 | Recruiting |
| HD Research - Memorial Hermann Village | Houston | Texas | 77043 | Recruiting |
| Endeavor Clinical Trials | San Antonio | Texas | 78240 | Recruiting |
| Spokane Joint Replacement Center | Spokane | Washington | 99218 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07213778, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 5, 2026 · Synced May 20, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07213778 live on ClinicalTrials.gov.