REGN7508 Versus Acetylsalicylic Acid (ASA) for Venous Thromboprophylaxis After Total Knee Arthroplasty in Adult Participants
Public ClinicalTrials.gov record NCT07213778. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Multicenter, Double-Blinded, Randomized Study to Evaluate REGN7508, a Factor XI Monoclonal Antibody, Versus Acetylsalicylic Acid for Prophylaxis of Symptomatic Venous Thromboembolism After Elective Total Knee Arthroplasty (ROXI-ASPEN)
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This study is researching an experimental drug called REGN7508 (called "study drug") and how it compares against another treatment called Acetylsalicylic Acid (ASA). The study is focused on adults undergoing elective, unilateral (one side) total knee replacement surgery. The aim of the study is to see how effective the study drug is at preventing Venous Thromboembolism (VTE) and other related diseases after total knee replacement surgery compared to acetylsalicylic acid. The study is looking at several other research questions, including: * What side effects may happen from taking the study drug * How much study drug is in the blood at different times * Whether the body makes antibodies against the study drug (which could make the study drug less effective or could lead to side effects)
Study identification
- NCT ID
- NCT07213778
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Enrollment
- 2,000 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Nov 24, 2025 (Actual)
- Primary completion
- May 17, 2027 (Estimated)
- Completion
- Jul 16, 2027 (Estimated)
- Last update posted
- Oct 22, 2026
2025 – 2027
United States locations
- U.S. sites
- 38
- U.S. states
- 17
- U.S. cities
- 33
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Horizon Clinical Research | La Mesa | California | 91942 | Recruiting |
| Eisenhower Medical Center | Rancho Mirage | California | 92270 | Recruiting |
| CARI Clinical Trials | Riverside | California | 92504 | Recruiting |
| HCA HealthONE Centennial | Englewood | Colorado | 80113 | Recruiting |
| HCA HealthONE, HCA HealthONE Sky Ridge | Lone Tree | Colorado | 80124 | Recruiting |
| South Florida Joint Replacement Center | Deerfield Beach | Florida | 33064 | Recruiting |
| Delray Physician Care Center | Delray Beach | Florida | 33445 | Recruiting |
| Medical Research of Westchester - MPLUS Research Network | Miami | Florida | 33165 | Recruiting |
| Larkin Community Hospital South Miami | South Miami | Florida | 33143 | Recruiting |
| Phoenix Clinical Research | Tamarac | Florida | 33321 | Recruiting |
| Endeavor Health | Skokie | Illinois | 60076 | Recruiting |
| The Orthopaedic Research Foundation, Inc. | Indianapolis | Indiana | 46278 | Recruiting |
| NextStage Clinical Research, St. Francis Medical Park | Wichita | Kansas | 67214 | Recruiting |
| Velocity Clinical Research, Annapolis | Annapolis | Maryland | 21401 | Recruiting |
| Sinai Hospital of Baltimore, Inc. | Baltimore | Maryland | 21215 | Recruiting |
| Tufts Medical Center | Boston | Massachusetts | 02111 | Recruiting |
| Boston Medical Center | Boston | Massachusetts | 02118 | Recruiting |
| Holy Name Medical Center | Teaneck | New Jersey | 07666 | Recruiting |
| Northwell Orthopaedic Institute | New York | New York | 10065 | Recruiting |
| University of Rochester Medical Center | Rochester | New York | 14623-5863 | Recruiting |
| UBMD Orthopaedics and Sports Medicine | Williamsville | New York | 14211 | Recruiting |
| Atrium Health Musculoskeletal Institute and Sports Medicine | Charlotte | North Carolina | 28211 | Recruiting |
| Duke University Health System (Duke Health), Duke University Hospital | Durham | North Carolina | 27710 | Recruiting |
| Eximia Equihealth Research-Raleigh. LLC | Raleigh | North Carolina | 27612 | Recruiting |
| The Vein and Vascular Center at Raleigh Radiology | Raleigh | North Carolina | 27612 | Recruiting |
| Coastal Vascular Institute, PA | Wilmington | North Carolina | 28401 | Recruiting |
| University of Cincinnati | Cincinnati | Ohio | 45267 | Recruiting |
| The Ohio State University Wexner Medical Center | Columbus | Ohio | 43210 | Recruiting |
| Ohio Clinical Trials | Columbus | Ohio | 43212 | Recruiting |
| Penn State Health Milton S. Hershey Medical Center | Hershey | Pennsylvania | 17033 | Recruiting |
| University of Pittsburgh | Pittsburgh | Pennsylvania | 15213-3108 | Recruiting |
| HD Research - Memorial Hermann Village | Houston | Texas | 77043 | Completed |
| NextStage Clinical Research, All American Orthopedics and Sports Medicine | Houston | Texas | 77058 | Recruiting |
| Flourish Research - San Antonio (Formerly Clinical Trials of Texas) | San Antonio | Texas | 78229 | Recruiting |
| Endeavor Clinical Trials | San Antonio | Texas | 78240 | Withdrawn |
| DRx Clinical Research, LLC | St. George | Utah | 84770 | Recruiting |
| Carilion Clinic | Roanoke | Virginia | 24015 | Recruiting |
| Spokane Joint Replacement Center | Spokane | Washington | 99218 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 13 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07213778, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 22, 2026 · Synced Oct 23, 2026
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Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07213778 live on ClinicalTrials.gov.