A Safety and Efficacy Study of a One-time Intravitreal Injection of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Public ClinicalTrials.gov record NCT07215234. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 1/2, Study to Evaluate the Safety, Tolerability, and Efficacy of One-time Intravitreal Dose of SAR446597 in Participants With Geographic Atrophy Secondary to Age-related Macular Degeneration
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
This is a sequential Phase 1/2, two-part, multicenter study on safety, tolerability, and efficacy of one-time intravitreal SAR446597 for the treatment of participants with Geographic Atrophy (GA) secondary to Age-related Macular Degeneration (AMD). The core phase duration will be approximately 2 years for each participant. An Extended Follow-Up (EFU) phase of 3 years follows the core phase. The treatment is a one-time intravitreal injection of SAR446597 (or sham as applicable in Part II).
Study identification
- NCT ID
- NCT07215234
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 1, Phase 2
- Enrollment
- 104 participants
Conditions and interventions
Conditions
Eligibility (public fields only)
- Age range
- 60 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 9, 2025 (Actual)
- Primary completion
- Oct 13, 2027 (Estimated)
- Completion
- Jul 22, 2032 (Estimated)
- Last update posted
- Oct 20, 2026
2025 – 2032
United States locations
- U.S. sites
- 31
- U.S. states
- 12
- U.S. cities
- 28
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Associated Retina Consultants - Peoria- Site Number : 8400011 | Peoria | Arizona | 85381 | Recruiting |
| Retina Macula Institute of Arizona- Site Number : 8400028 | Scottsdale | Arizona | 85255 | Recruiting |
| Retina-Vitreous Associates Medical Group - Beverly Hills- Site Number : 8400033 | Beverly Hills | California | 90211 | Recruiting |
| The Retina Partners- Site Number : 8400040 | Encino | California | 91436 | Recruiting |
| California Retina Consultants - Oxnard - North Ventura Road- Site Number : 8400014 | Oxnard | California | 93036 | Recruiting |
| Retinal Consultants - Sacramento - Parkcenter Drive- Site Number : 8400054 | Sacramento | California | 95825 | Recruiting |
| Macula Retina Vitreous Center - Torrance- Site Number : 8400053 | Torrance | California | 90503 | Recruiting |
| Bay Area Retina Associates - Walnut Creek - Lennon Lane- Site Number : 8400039 | Walnut Creek | California | 94598 | Recruiting |
| Vitreo Retinal Associates - Gainesville- Site Number : 8400004 | Gainesville | Florida | 32607 | Recruiting |
| Retina Vitreous Associates of Florida - St. Petersburg- Site Number : 8400002 | St. Petersburg | Florida | 33711 | Recruiting |
| East Florida Eye Institute- Site Number : 8400038 | Stuart | Florida | 34994 | Recruiting |
| Southeast Retina Center- Site Number : 8400044 | Augusta | Georgia | 30909 | Recruiting |
| University Retina - Lemont- Site Number : 8400005 | Lemont | Illinois | 60439 | Recruiting |
| The Retina Group of Washington - Chevy Chase- Site Number : 8400009 | Chevy Chase | Maryland | 20815 | Recruiting |
| Cumberland Valley Retina Consultants - Hagerstown- Site Number : 8400003 | Hagerstown | Maryland | 21740 | Recruiting |
| Retina Specialist- Site Number : 8400055 | Towson | Maryland | 21204 | Recruiting |
| Sierra Eye Associates- Site Number : 8400021 | Reno | Nevada | 89502 | Recruiting |
| North Carolina (Nc) Retina Associates - Wake Forest Office- Site Number : 8400059 | Wake Forest | North Carolina | 27587-3803 | Recruiting |
| Oregon Retina- Site Number : 8400017 | Eugene | Oregon | 97401 | Recruiting |
| Mid Atlantic Retina - Bethlehem- Site Number : 8400031 | Bethlehem | Pennsylvania | 18017-9412 | Recruiting |
| Erie Retina Research- Site Number : 8400035 | Erie | Pennsylvania | 16505 | Recruiting |
| Charleston Neuroscience Institute - Ladson- Site Number : 8400016 | Ladson | South Carolina | 29456 | Recruiting |
| Charleston Neuroscience Institute - Ladson- Site Number : 8400046 | Ladson | South Carolina | 29456 | Recruiting |
| Texas Retina Associates - Arlington- Site Number : 8400056 | Arlington | Texas | 76012 | Recruiting |
| Retina Consultants of Austin- Site Number : 8400015 | Austin | Texas | 78705 | Recruiting |
| Austin Clinical Research - Austin - Anderson Mill Road- Site Number : 8400007 | Austin | Texas | 78750 | Recruiting |
| Retina Consultants of Texas - Bellaire- Site Number : 8400019 | Bellaire | Texas | 77401 | Recruiting |
| Retina Foundation of the Southwest- Site Number : 8400001 | Dallas | Texas | 75231 | Recruiting |
| Texas Retina Associates - Dallas- Site Number : 8400006 | Dallas | Texas | 75231 | Recruiting |
| Retinal Consultants of Texas - San Antonio- Site Number : 8400012 | San Antonio | Texas | 78240 | Recruiting |
| Retina Center of Texas (RCT) - Southlake- Site Number : 8400048 | Southlake | Texas | 76092 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 4 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07215234, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Oct 20, 2026 · Synced Oct 22, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete public registry record, listed eligibility criteria, and available contact information for NCT07215234 live on ClinicalTrials.gov.