A Study of ZL-1310 Versus Investigator's Choice of Therapy in Participants With Relapsed Small Cell Lung Cancer (DLLEVATE)

ClinicalTrials.gov ID: NCT07218146

Public ClinicalTrials.gov record NCT07218146. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 20, 2026, 11:29 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomized, Open-Label, Phase 3 Study of ZL-1310, a DLL3 Antibody-Drug Conjugate (ADC), Compared to Investigator's Choice Therapy in Participants With Relapsed Small Cell Lung Cancer

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The purpose of this study is to evaluate the efficacy and safety of ZL-1310 compared to Investigator's Choice Therapy in participants with relapsed Small Cell Lung Cancer.

Study identification

NCT ID: NCT07218146
Recruitment status: Recruiting
Study type: Interventional
Phase: Phase 3
Lead sponsor: Zai Lab (Shanghai) Co., Ltd.; Industry
Enrollment: 480 participants

Conditions and interventions

Conditions

Small-cell Lung Cancer

Interventions

ZL-1310 Drug
Investigator's Choice of Therapy Drug

Drug

Eligibility (public fields only)

Age range: 18 Years and older
Sex: All
Healthy volunteers: Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date: Nov 30, 2025 (Actual)
Primary completion: Jun 30, 2028 (Estimated)
Completion: Nov 30, 2028 (Estimated)
Last update posted: Oct 16, 2026

2025 – 2028

United States locations

U.S. sites: 37
U.S. states: 16
U.S. cities: 33

Facility	City	State	ZIP	Site status
University of California San Diego	La Jolla	California	92093	Recruiting
UC Davis Comprehensive Cancer Center	Sacramento	California	95817	Recruiting
University of Colorado	Aurora	Colorado	80045	Recruiting
Yale Cancer Center/Clinical Trials Office	New Haven	Connecticut	06519	Recruiting
Clermont Oncology Center	Clermont	Florida	34711	Recruiting
Mid Florida Hematology and Oncology Center	Orange City	Florida	32763	Recruiting
Cancer Centers of Bevard	Rockledge	Florida	32955	Recruiting
Sarah Cannon Research Institute	Sarasota	Florida	34232	Recruiting
Florida Cancer Specialists - North	St. Petersburg	Florida	33701-4553	Recruiting
Moffitt Cancer Center	Tampa	Florida	33612	Recruiting
Florida Cancer Specialists - East	West Palm Beach	Florida	33401	Recruiting
Illinois Cancer Care	Peoria	Illinois	61615	Recruiting
OSF St. Francis Medical Center	Peoria	Illinois	61637	Recruiting
University of Iowa	Iowa City	Iowa	52242	Recruiting
University of Iowa Mission Health Cancer + Blood	Waukee	Iowa	50263	Recruiting
Norton Cancer Institute	Louisville	Kentucky	40202	Recruiting
American Oncology Partners, PA - The Center for Cancer and Blood Disorders	Bethesda	Maryland	20817	Recruiting
Maryland Oncology Hematology	Silver Spring	Maryland	20904	Recruiting
Henry Ford Health Cancer	Detroit	Michigan	48202	Recruiting
Missouri Cancer Associates	Columbia	Missouri	65201	Recruiting
Mercy South	St Louis	Missouri	63128	Recruiting
Stony Brook Cancer Center	Stony Brook	New York	11794-7007	Recruiting
Montefiore Medical Center	The Bronx	New York	10461	Recruiting
Cleveland Clinic - Akron General Medical Center	Akron	Ohio	44302	Recruiting
University Hospitals Cleveland Medical Center	Cleveland	Ohio	44106	Recruiting
Cleveland Clinic - Fairview Hospital Molly Pavilion	Cleveland	Ohio	44111	Recruiting
Cleveland Clinic	Cleveland	Ohio	44195	Recruiting
Cleveland Clinic - Hillcrest Hospital Cancer Center	Mayfield Heights	Ohio	44124	Recruiting
Consultants in Medical Oncology and Hematology	Broomall	Pennsylvania	19008	Recruiting
Alliance Cancer Specialists	Media	Pennsylvania	19063	Recruiting
Allegheny General Hospital	Pittsburgh	Pennsylvania	15212	Recruiting
University of Pittsburgh (UPMC) Hillman Cancer Center	Pittsburgh	Pennsylvania	15232	Recruiting
SCRI OP (Oncology Partners)	Nashville	Tennessee	37203	Recruiting
Texas Oncology - Central South	Austin	Texas	78745	Recruiting
University of Texas Southwestern Medical Center/Clinical Research Department	Dallas	Texas	75390-9020	Recruiting
Texas Oncology - West Texas	Odessa	Texas	79761	Recruiting
Virginia Cancer Specialists	Fairfax	Virginia	22031	Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 128 non-U.S. sites.

About this trial record page

What this page shows: Public field values for ClinicalTrials.gov record NCT07218146, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do: No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from: Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh: Last update posted Oct 16, 2026 · Synced Oct 20, 2026

Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07218146 live on ClinicalTrials.gov.

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