ClinicalTrials.gov record
A Study of Vepugratinib (LY3866288) in Participants With Cancer in the Urinary Tract
ClinicalTrials.gov ID: NCT07218380
Public ClinicalTrials.gov record NCT07218380. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 5, 2026, 6:36 AM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
FORAGER-2: A Phase 3, Randomized, Double-blind, Placebo-controlled Study Evaluating the Efficacy and Safety of Vepugratinib Combined With Enfortumab Vedotin and Pembrolizumab in Adults With Untreated Locally Advanced or Metastatic Urothelial Carcinoma With an FGFR3 Genetic Alteration
Study identification
- NCT ID
- NCT07218380
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- Eli Lilly and Company
- Industry
- Enrollment
- 450 participants
Conditions and interventions
Interventions
- EV Drug
- Pembrolizumab Drug
- Placebo Other
- Vepugratinib Drug
Drug · Other
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 11, 2025
- Primary completion
- Sep 30, 2029
- Completion
- Apr 30, 2033
- Last update posted
- Apr 16, 2026
2025 – 2033
United States locations
- U.S. sites
- 56
- U.S. states
- 25
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Clearview Cancer Institute | Huntsville | Alabama | 35805 | Recruiting |
| The University of Arizona Cancer Center - North Campus | Tucson | Arizona | 85719 | Not yet recruiting |
| Chao Family Comprehensive Cancer Center and Ambulatory Care (CIACC) - Irvine | Irvine | California | 92612 | Not yet recruiting |
| TRIO-US (Translational Research in Oncology-US) | Los Angeles | California | 90024 | Not yet recruiting |
| UCLA Hematology/Oncology - Santa Monica | Los Angeles | California | 90404 | Not yet recruiting |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center | Orange | California | 92868 | Not yet recruiting |
| University of California Davis (UC Davis) Comprehensive Cancer Center | Sacramento | California | 95817 | Not yet recruiting |
| UCSF Medical Center at Mission Bay | San Francisco | California | 94158 | Recruiting |
| Hunt Cancer Institute, an Affiliate of Cedars-Sinai Cancer (TMPN) | Torrance | California | 90505 | Recruiting |
| AdventHealth Medical Group - Porter | Denver | Colorado | 80210 | Not yet recruiting |
| Colorado West Healthcare System - Grand Valley Oncology | Grand Junction | Colorado | 81505 | Recruiting |
| AdventHealth Orlando | Orlando | Florida | 32804 | Not yet recruiting |
| St. Luke's Cancer Institute: Boise | Boise | Idaho | 83712 | Not yet recruiting |
| University of Illinois at Chicago | Chicago | Illinois | 60612 | Recruiting |
| University of Chicago Medical Center | Chicago | Illinois | 60637 | Not yet recruiting |
| Parkview Research Center at Parkview Regional Medical Center | Fort Wayne | Indiana | 46845 | Not yet recruiting |
| Indiana University Melvin and Bren Simon Cancer Center | Indianapolis | Indiana | 46202 | Recruiting |
| Franciscan Health | Indianapolis | Indiana | 46237 | Recruiting |
| University of Kentucky Chandler Medical Center | Lexington | Kentucky | 40536 | Suspended |
| Mary Bird Perkins Cancer Center | Baton Rouge | Louisiana | 70809 | Recruiting |
| Ochsner Clinic Foundation | New Orleans | Louisiana | 70121 | Not yet recruiting |
| Johns Hopkins Hospital | Baltimore | Maryland | 21287 | Not yet recruiting |
| Massachusetts General Hospital | Boston | Massachusetts | 02114 | Not yet recruiting |
| Karmanos Cancer Institute | Detroit | Michigan | 48201 | Not yet recruiting |
| Brigitte Harris Cancer Pavilion | Detroit | Michigan | 48202 | Not yet recruiting |
| Oncology Hematology Associates | Springfield | Missouri | 65807 | Not yet recruiting |
| Washington University School of Medicine | St Louis | Missouri | 63108 | Recruiting |
| Comprehensive Cancer Centers of Nevada | Las Vegas | Nevada | 89148 | Recruiting |
| Astera Cancer Care | East Brunswick | New Jersey | 08816 | Not yet recruiting |
| Columbia University Irving Medical Center | New York | New York | 10032 | Not yet recruiting |
| Memorial Sloan Kettering Cancer Center | New York | New York | 10065 | Recruiting |
| Weill Cornell Medical College | New York | New York | 10065 | Not yet recruiting |
| Wilmot Cancer Institute | Rochester | New York | 14642 | Not yet recruiting |
| Levine Cancer Institute | Charlotte | North Carolina | 28204 | Not yet recruiting |
| Oncology Specialists of Charlotte | Charlotte | North Carolina | 28207 | Recruiting |
| University of Cincinnati Medical Center | Cincinnati | Ohio | 45219 | Not yet recruiting |
| The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer -T | Columbus | Ohio | 43210 | Not yet recruiting |
| Providence Portland Medical Center | Portland | Oregon | 97213 | Recruiting |
| Providence St. Vincent Medical Center | Portland | Oregon | 97225 | Recruiting |
| Kaiser Permanente Interstate Medical Office Central | Portland | Oregon | 97227 | Recruiting |
| Oregon Health and Science University | Portland | Oregon | 97239 | Not yet recruiting |
| Lancaster General Hospital - Ann B Barshinger Cancer Institute | Lancaster | Pennsylvania | 17601 | Not yet recruiting |
| AHN Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | Not yet recruiting |
| Avera Cancer Institute- Research | Sioux Falls | South Dakota | 57105 | Recruiting |
| Sarah Cannon Research Institute | Nashville | Tennessee | 37203 | Not yet recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Tennessee Oncology | Nashville | Tennessee | 37203 | Recruiting |
| USO-Texas Oncology-Central/South Texas | Austin | Texas | 78731 | Recruiting |
| World Research Link | Baytown | Texas | 77521 | Recruiting |
| Parkland Health and Hospital System | Dallas | Texas | 75235 | Not yet recruiting |
| UT Southwestern Medical Center | Dallas | Texas | 75390 | Recruiting |
| University of Texas MD Anderson Cancer Center | Houston | Texas | 77030-4009 | Not yet recruiting |
| Nova Oncology | McAllen | Texas | 78504 | Recruiting |
| US Oncology Research Network | The Woodlands | Texas | 77380 | Recruiting |
| USO - Texas Oncology - Northeast Texas | Tyler | Texas | 75702 | Recruiting |
| USO - Virginia Oncology Associates | Norfolk | Virginia | 23502 | Not yet recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 225 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07218380, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 16, 2026 · Synced May 5, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07218380 live on ClinicalTrials.gov.