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Recruiting Phase 3 Interventional

AZD5335 vs. Mirvetuximab Soravtansine in FRα-high and AZD5335 vs. Chemotherapy in FRα-low Platinum-resistant Ovarian Cancer

ClinicalTrials.gov ID: NCT07218809

Public ClinicalTrials.gov record NCT07218809. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Sep 8, 2026, 7:50 AM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Randomised, Open-label, Phase III Study of AZD5335 Versus Mirvetuximab Soravtansine in FRα-high and AZD5335 Versus Investigator's Choice Chemotherapy in FRα-low Expressing High-grade Platinum-resistant Epithelial Ovarian Cancer Patients (TREVI-OC-01)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

The intention of the study is to demonstrate superiority of AZD5335 versus standard of care by assessment of progression-free survival (PFS) in women with high-grade, platinum-resistant epithelial ovarian, fallopian tube, or primary peritoneal cancer, expressing high or low FRα levels.

Study identification

NCT ID
NCT07218809
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
AstraZeneca
Industry
Enrollment
1,100 participants

Conditions and interventions

Eligibility (public fields only)

Age range
18 Years and older
Sex
Female
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 28, 2025
Primary completion
Nov 16, 2028
Completion
Dec 26, 2029
Last update posted
Jul 20, 2026

2025 – 2029

United States locations

U.S. sites
40
U.S. states
27
U.S. cities
40
Facility City State ZIP Site status
Research Site Birmingham Alabama 35223 Recruiting
Research Site Little Rock Arkansas 72205 Not yet recruiting
Research Site La Jolla California 92037 Not yet recruiting
Research Site Washington D.C. District of Columbia 20010 Recruiting
Research Site Fort Lauderdale Florida 33316 Not yet recruiting
Research Site Gainesville Florida 32608 Recruiting
Research Site Jupiter Florida 33458 Recruiting
Research Site Miami Florida 33176 Recruiting
Research Site Weston Florida 33331 Not yet recruiting
Research Site Chicago Illinois 60612 Not yet recruiting
Research Site Evanston Illinois 60201 Not yet recruiting
Research Site Peoria Illinois 61637 Recruiting
Research Site Urbana Illinois 61801 Recruiting
Research Site Fort Wayne Indiana 46845 Recruiting
Research Site Indianapolis Indiana 46202 Recruiting
Research Site Louisville Kentucky 40241 Recruiting
Research Site Towson Maryland 21204 Recruiting
Research Site Burlington Massachusetts 01805 Recruiting
Research Site Worcester Massachusetts 01655 Not yet recruiting
Research Site Minneapolis Minnesota 55404 Recruiting
Research Site Springfield Missouri 65807 Recruiting
Research Site Billings Montana 59106 Recruiting
Research Site Omaha Nebraska 68114 Recruiting
Research Site Las Vegas Nevada 89106 Recruiting
Research Site Lebanon New Hampshire 03756 Not yet recruiting
Research Site Camden New Jersey 08103 Not yet recruiting
Research Site The Bronx New York 10461 Not yet recruiting
Research Site Chapel Hill North Carolina 27599 Recruiting
Research Site Blue Ash Ohio 45242 Recruiting
Research Site Dayton Ohio 45459 Recruiting
Research Site Sylvania Ohio 43560 Not yet recruiting
Research Site Portland Oregon 97213 Recruiting
Research Site York Pennsylvania 17403 Not yet recruiting
Research Site Germantown Tennessee 38138 Recruiting
Research Site San Antonio Texas 78229 Recruiting
Research Site Tyler Texas 75702 Recruiting
Research Site Salt Lake City Utah 84106 Withdrawn
Research Site Fairfax Virginia 22031 Recruiting
Research Site Roanoke Virginia 24016 Recruiting
Research Site Seattle Washington 98104 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 259 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07218809, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Jul 20, 2026 · Synced Sep 8, 2026

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Open the official record

The complete protocol, eligibility criteria, and contact information for NCT07218809 live on ClinicalTrials.gov.

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