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Recruiting Phase 3 Interventional

A Clinical Study to Investigate the Safety and Tolerability of Efimosfermin Alfa Injection in Participants With Known or Suspected F2- or F3-stage MASH

ClinicalTrials.gov ID: NCT07221188

Public ClinicalTrials.gov record NCT07221188. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.

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ClinicalTrials.gov public records Last synced Oct 16, 2026, 9:35 PM EDT

Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.

Official title

A Phase 3, Randomized, Double-Blind, Placebo-Controlled, 3-Arm Study to Investigate the Safety and Tolerability of Efimosfermin Alfa in Participants With Known or Suspected F2- or F3-Stage Metabolic Dysfunction-Associated Steatohepatitis (MASH) (ZENITH-2)

Brief summary

Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.

This study will evaluate the safety and tolerability of Efimosfermin Alfa for participants with known or suspected MASH with fibrosis consistent with stage F2 or F3.

Study identification

NCT ID
NCT07221188
Recruitment status
Recruiting
Study type
Interventional
Phase
Phase 3
Lead sponsor
GlaxoSmithKline
Industry
Enrollment
1,250 participants

Conditions and interventions

Interventions

Drug

Eligibility (public fields only)

Age range
18 Years to 75 Years
Sex
All
Healthy volunteers
Healthy volunteers not accepted

This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.

Study timeline

Start date
Dec 12, 2025 (Actual)
Primary completion
Mar 24, 2028 (Estimated)
Completion
Mar 24, 2028 (Estimated)
Last update posted
Sep 17, 2026

2025 – 2028

United States locations

U.S. sites
57
U.S. states
14
U.S. cities
47
Facility City State ZIP Site status
GSK Investigational Site Arcadia California 91006 Recruiting
GSK Investigational Site Covina California 91723 Recruiting
GSK Investigational Site Los Angeles California 90057 Recruiting
GSK Investigational Site San Diego California 92120 Recruiting
GSK Investigational Site Santa Maria California 93458 Recruiting
GSK Investigational Site Van Nuys California 91405 Recruiting
GSK Investigational Site Boynton Beach Florida 33435-5610 Recruiting
GSK Investigational Site Cape Coral Florida 33914 Recruiting
GSK Investigational Site Clermont Florida 34711 Recruiting
GSK Investigational Site Doral Florida 33016 Recruiting
GSK Investigational Site Fort Myers Florida 33912 Recruiting
GSK Investigational Site Hialeah Florida 33016 Recruiting
GSK Investigational Site Homestead Florida 33033 Recruiting
GSK Investigational Site Inverness Florida 34452 Recruiting
GSK Investigational Site Jacksonville Florida 32216 Recruiting
GSK Investigational Site Kissimmee Florida 34744 Recruiting
GSK Investigational Site Lakeland Florida 33803 Recruiting
GSK Investigational Site Maitland Florida 32751 Recruiting
GSK Investigational Site Miami Florida 33135-4661 Recruiting
GSK Investigational Site Miami Florida 33144 Recruiting
GSK Investigational Site Miami Florida 33155 Recruiting
GSK Investigational Site Miami Florida 33156-7397 Recruiting
GSK Investigational Site Miami Florida 33173-3484 Recruiting
GSK Investigational Site Miami Florida 33184 Recruiting
GSK Investigational Site Miami Lakes Florida 33014 Recruiting
GSK Investigational Site Ocala Florida 34471 Recruiting
GSK Investigational Site Palmetto Bay Florida 33157 Recruiting
GSK Investigational Site Sarasota Florida 34201 Recruiting
GSK Investigational Site Topeka Kansas 66606 Recruiting
GSK Investigational Site Marrero Louisiana 70072 Recruiting
GSK Investigational Site Springfield Missouri 62703 Recruiting
GSK Investigational Site St Louis Missouri 63123 Recruiting
GSK Investigational Site St Louis Missouri 63141 Recruiting
GSK Investigational Site Jersey City New Jersey 07059 Recruiting
GSK Investigational Site East Syracuse New York 13057 Recruiting
GSK Investigational Site New York New York 10036-4103 Recruiting
GSK Investigational Site Morehead City North Carolina 28557 Recruiting
GSK Investigational Site Akron Ohio 44320 Recruiting
GSK Investigational Site Springboro Ohio 45066 Recruiting
GSK Investigational Site Chattanooga Tennessee 37421 Recruiting
GSK Investigational Site Austin Texas 78745-5675 Recruiting
GSK Investigational Site Austin Texas 78759 Recruiting
GSK Investigational Site Brownsville Texas 78526 Recruiting
GSK Investigational Site Dallas Texas 75243 Recruiting
GSK Investigational Site DeSoto Texas 75115 Recruiting
GSK Investigational Site Richmond Texas 77406 Recruiting
GSK Investigational Site San Antonio Texas 78209 Recruiting
GSK Investigational Site San Antonio Texas 78215 Recruiting
GSK Investigational Site San Antonio Texas 78229 Recruiting
GSK Investigational Site Seabrook Texas 77586 Recruiting
GSK Investigational Site Sugar Land Texas 77479 Recruiting
GSK Investigational Site Tomball Texas 77375 Recruiting
GSK Investigational Site Waco Texas 76710 Recruiting
GSK Investigational Site Waco Texas 76712 Recruiting
GSK Investigational Site West Jordan Utah 84088 Recruiting
GSK Investigational Site Manassas Virginia 20110 Recruiting
GSK Investigational Site Seattle Washington 98105 Recruiting

Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.

Non-U.S. locations

This page focuses on the U.S. directory. The official record also lists 8 non-U.S. sites.

About this trial record page

What this page shows
Public field values for ClinicalTrials.gov record NCT07221188, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
What this page does not do
No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
Where the data comes from
Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
Last refresh
Last update posted Sep 17, 2026 · Synced Oct 16, 2026

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Open the official record

The complete public registry record, listed eligibility criteria, and available contact information for NCT07221188 live on ClinicalTrials.gov.

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