A Pivotal Clinical Study to Investigate Efimosfermin Alfa in Participants With Biopsy-confirmed F2- or F3-stage MASH
Public ClinicalTrials.gov record NCT07221227. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
A Phase 3, Randomized, Double-Blind, Placebo-Controlled, 3-Arm Study to Investigate the Safety and Efficacy of Efimosfermin Alfa in Participants With Biopsy-Confirmed F2- or F3-Stage Metabolic Dysfunction-Associated Steatohepatitis (MASH) (ZENITH-1)
Study identification
- NCT ID
- NCT07221227
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 3
- Lead sponsor
- GlaxoSmithKline
- Industry
- Enrollment
- 1,200 participants
Conditions and interventions
Conditions
Interventions
- Efimosfermin alfa Drug
- Placebo Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years to 75 Years
- Sex
- All
- Healthy volunteers
- Not listed
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Oct 23, 2025
- Primary completion
- Mar 28, 2028
- Completion
- Dec 11, 2031
- Last update posted
- Apr 15, 2026
2025 – 2031
United States locations
- U.S. sites
- 47
- U.S. states
- 12
- U.S. cities
- 40
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| GSK Investigational Site | Arcadia | California | 91006 | Recruiting |
| GSK Investigational Site | Covina | California | 91723 | Recruiting |
| GSK Investigational Site | Los Angeles | California | 90057 | Recruiting |
| GSK Investigational Site | Santa Maria | California | 93458 | Recruiting |
| GSK Investigational Site | Van Nuys | California | 91405 | Recruiting |
| GSK Investigational Site | Boynton Beach | Florida | 33435 | Recruiting |
| GSK Investigational Site | Cape Coral | Florida | 33914 | Recruiting |
| GSK Investigational Site | Hialeah | Florida | 33016 | Recruiting |
| GSK Investigational Site | Inverness | Florida | 34452 | Recruiting |
| GSK Investigational Site | Jacksonville | Florida | 32216 | Recruiting |
| GSK Investigational Site | Kissimmee | Florida | 34744 | Recruiting |
| GSK Investigational Site | Lakeland | Florida | 33803 | Recruiting |
| GSK Investigational Site | Maitland | Florida | 32751 | Recruiting |
| GSK Investigational Site | Miami | Florida | 33135 | Recruiting |
| GSK Investigational Site | Miami | Florida | 33144 | Recruiting |
| GSK Investigational Site | Miami | Florida | 33155 | Recruiting |
| GSK Investigational Site | Miami | Florida | 33156 | Recruiting |
| GSK Investigational Site | Miami | Florida | 33184 | Recruiting |
| GSK Investigational Site | Miami Lakes | Florida | 33014 | Recruiting |
| GSK Investigational Site | Ocala | Florida | 34471 | Recruiting |
| GSK Investigational Site | Palmetto Bay | Florida | 33157 | Recruiting |
| GSK Investigational Site | Topeka | Kansas | 66606 | Recruiting |
| GSK Investigational Site | Springfield | Missouri | 62703 | Recruiting |
| GSK Investigational Site | St Louis | Missouri | 63141 | Recruiting |
| GSK Investigational Site | East Syracuse | New York | 13057 | Recruiting |
| GSK Investigational Site | New York | New York | 10036 | Recruiting |
| GSK Investigational Site | Morehead City | North Carolina | 28557 | Recruiting |
| GSK Investigational Site | Akron | Ohio | 44320 | Recruiting |
| GSK Investigational Site | Springboro | Ohio | 45066 | Recruiting |
| GSK Investigational Site | Chattanooga | Tennessee | 37421 | Recruiting |
| GSK Investigational Site | Austin | Texas | 78704 | Recruiting |
| GSK Investigational Site | Austin | Texas | 78759 | Recruiting |
| GSK Investigational Site | Bellaire | Texas | 77401 | Recruiting |
| GSK Investigational Site | Brownsville | Texas | 78526 | Recruiting |
| GSK Investigational Site | Dallas | Texas | 75243 | Recruiting |
| GSK Investigational Site | DeSoto | Texas | 75115 | Recruiting |
| GSK Investigational Site | Richmond | Texas | 77406 | Recruiting |
| GSK Investigational Site | San Antonio | Texas | 78215 | Recruiting |
| GSK Investigational Site | San Antonio | Texas | 78229 | Recruiting |
| GSK Investigational Site | Seabrook | Texas | 77586 | Recruiting |
| GSK Investigational Site | Sugar Land | Texas | 77479 | Recruiting |
| GSK Investigational Site | Tomball | Texas | 77375 | Recruiting |
| GSK Investigational Site | Waco | Texas | 76710 | Recruiting |
| GSK Investigational Site | Waco | Texas | 76712 | Recruiting |
| GSK Investigational Site | West Jordan | Utah | 84088 | Recruiting |
| GSK Investigational Site | Manassas | Virginia | 20110 | Recruiting |
| GSK Investigational Site | Seattle | Washington | 98105 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07221227, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Apr 15, 2026 · Synced Apr 22, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07221227 live on ClinicalTrials.gov.