A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Public ClinicalTrials.gov record NCT07221357. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
ROSETTA CRC-203: A Blinded, Randomized Phase 2/3 Study of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Brief summary
Reproduced verbatim from the official ClinicalTrials.gov record. Not medical advice.
The purpose of this study is to evaluate the safety and efficacy of pumitamig in combination with chemotherapy versus bevacizumab in combination with chemotherapy in participants with previously untreated, unresectable, or metastatic colorectal cancer
Study identification
- NCT ID
- NCT07221357
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Enrollment
- 990 participants
Conditions and interventions
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 30, 2025
- Primary completion
- Feb 1, 2030
- Completion
- Mar 10, 2034
- Last update posted
- Aug 16, 2026
2025 – 2034
United States locations
- U.S. sites
- 46
- U.S. states
- 25
- U.S. cities
- 43
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0428 | Tucson | Arizona | 85724 | Not yet recruiting |
| Highlands Oncology Group | Springdale | Arkansas | 72762 | Recruiting |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | Recruiting |
| Local Institution - 0330 | Los Angeles | California | 90404 | Withdrawn |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center | Orange | California | 92868 | Recruiting |
| Local Institution - 0317 | San Francisco | California | 94115 | Not yet recruiting |
| Florida Cancer Specialists - East | Cape Coral | Florida | 33990 | Recruiting |
| Florida Cancer Specialists - North | St. Petersburg | Florida | 33705 | Recruiting |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Recruiting |
| Local Institution - 0326 | Atlanta | Georgia | 30318 | Not yet recruiting |
| Northside Hospital | Atlanta | Georgia | 30342 | Recruiting |
| Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital | Marietta | Georgia | 30060 | Recruiting |
| Local Institution - 0433 | Chicago | Illinois | 60637 | Not yet recruiting |
| Local Institution - 0638 | Fort Wayne | Indiana | 46805 | Not yet recruiting |
| Local Institution - 0335 | Iowa City | Iowa | 52242 | Not yet recruiting |
| Local Institution - 0262 | Baltimore | Maryland | 21287 | Not yet recruiting |
| Maryland Oncology Hematology - Silver Spring | Silver Spring | Maryland | 20904 | Recruiting |
| Local Institution - 0471 | Boston | Massachusetts | 02114 | Withdrawn |
| Local Institution - 0430 | Ann Arbor | Michigan | 48109 | Not yet recruiting |
| Local Institution - 0254 | Grand Rapids | Michigan | 49546 | Not yet recruiting |
| Minnesota Oncology | Maple Grove | Minnesota | 55369 | Recruiting |
| Local Institution - 0318 | Kansas City | Missouri | 64111 | Not yet recruiting |
| Washington University School OF Medicine-Siteman Cancer Center | St Louis | Missouri | 63110 | Recruiting |
| University Of Nebraska Medical Center | Omaha | Nebraska | 68198 | Recruiting |
| Northwell Health/ RJ Zuckerberg Cancer Center | Lake Success | New York | 11042 | Recruiting |
| Laura and Isaac Perlmutter Cancer Center at NYU Langone | Mineola | New York | 11501 | Recruiting |
| New York Cancer and Blood Specialists | Shirley | New York | 11967 | Recruiting |
| Local Institution - 0290 | Charlotte | North Carolina | 28207 | Not yet recruiting |
| Sanford Fargo Medical Center | Fargo | North Dakota | 58102 | Recruiting |
| The James Cancer Hospital and Solove Research Institute at The Ohio State University Comprehensive Cancer Center | Columbus | Ohio | 43210 | Recruiting |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | Recruiting |
| Local Institution - 0604 | Pittsburgh | Pennsylvania | 15232 | Not yet recruiting |
| Sanford Cancer Center | Sioux Falls | South Dakota | 57104 | Recruiting |
| Local Institution - 0333 | Nashville | Tennessee | 37203 | Not yet recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Texas Oncology Dallas Fort Worth West (DFWW) - Arlington Cancer Center North | Arlington | Texas | 76012 | Recruiting |
| Texas Oncology, PA | Austin | Texas | 78705 | Recruiting |
| Baylor College of Medicine Medical Center | Houston | Texas | 77030 | Recruiting |
| Texas Oncology - San Antonio | San Antonio | Texas | 78240 | Recruiting |
| Local Institution - 0426 | Salt Lake City | Utah | 84102 | Not yet recruiting |
| Local Institution - 0278 | Fairfax | Virginia | 22031 | Not yet recruiting |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | Recruiting |
| Local Institution - 0491 | Edmonds | Washington | 98026-8032 | Not yet recruiting |
| Local Institution - 0253 | Seattle | Washington | 98109 | Not yet recruiting |
| Local Institution - 0629 | Spokane | Washington | 99218 | Not yet recruiting |
| Northwest Cancer Specialists, P.C. | Vancouver | Washington | 98684 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 237 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07221357, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted Aug 16, 2026 · Synced Sep 3, 2026
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Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07221357 live on ClinicalTrials.gov.