ClinicalTrials.gov record
A Study to Evaluate the Safety and Efficacy of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
ClinicalTrials.gov ID: NCT07221357
Public ClinicalTrials.gov record NCT07221357. Field values are reproduced from the official study page; the official ClinicalTrials.gov record remains the source of truth for eligibility, enrollment, and contact information.
ClinicalTrials.gov public records Last synced May 7, 2026, 12:45 PM EDT
Data is sourced from official ClinicalTrials.gov public API records. Always review the official ClinicalTrials.gov record for the latest information.
Official title
ROSETTA CRC-203: A Blinded, Randomized Phase 2/3 Study of Pumitamig in Combination With Chemotherapy Versus Bevacizumab in Combination With Chemotherapy in Participants With Previously Untreated, Unresectable, or Metastatic Colorectal Cancer
Study identification
- NCT ID
- NCT07221357
- Recruitment status
- Recruiting
- Study type
- Interventional
- Phase
- Phase 2, Phase 3
- Lead sponsor
- Bristol-Myers Squibb
- Industry
- Enrollment
- 990 participants
Conditions and interventions
Interventions
- Bevacizumab Drug
- CAPOX Drug
- FOLFIRI Drug
- FOLFOX Drug
- Pumitamig Drug
Drug
Eligibility (public fields only)
- Age range
- 18 Years and older
- Sex
- All
- Healthy volunteers
- Healthy volunteers not accepted
This page does not interpret eligibility. Detailed inclusion and exclusion criteria are on the official ClinicalTrials.gov record.
Study timeline
- Start date
- Dec 30, 2025
- Primary completion
- Feb 1, 2030
- Completion
- Mar 10, 2034
- Last update posted
- May 5, 2026
2025 – 2034
United States locations
- U.S. sites
- 49
- U.S. states
- 26
- U.S. cities
- 47
| Facility | City | State | ZIP | Site status |
|---|---|---|---|---|
| Local Institution - 0428 | Tucson | Arizona | 85724 | Not yet recruiting |
| Local Institution - 0432 | Springdale | Arkansas | 72762 | Not yet recruiting |
| Local Institution - 0447 | La Jolla | California | 92037 | Not yet recruiting |
| USC/Norris Comprehensive Cancer Center | Los Angeles | California | 90033 | Recruiting |
| University of California, Irvine (UCI) Health - UC Irvine Medical Center | Orange | California | 92868 | Recruiting |
| Local Institution - 0317 | San Francisco | California | 94115 | Not yet recruiting |
| Local Institution - 0330 | Santa Monica | California | 90404 | Not yet recruiting |
| Local Institution - 0293 | Stanford | California | 94305 | Not yet recruiting |
| Florida Cancer Specialists - East | Cape Coral | Florida | 33990 | Recruiting |
| Florida Cancer Specialists - North | St. Petersburg | Florida | 33705 | Recruiting |
| Moffitt Cancer Center | Tampa | Florida | 33612 | Recruiting |
| Local Institution - 0276 | Atlanta | Georgia | 30342 | Not yet recruiting |
| Northwest Georgia Oncology Centers, a Service of Wellstar Cobb Hospital | Marietta | Georgia | 30060 | Recruiting |
| Local Institution - 0030 | Chicago | Illinois | 60611 | Not yet recruiting |
| Local Institution - 0433 | Chicago | Illinois | 60637 | Not yet recruiting |
| Local Institution - 0638 | Fort Wayne | Indiana | 46805 | Not yet recruiting |
| Local Institution - 0335 | Iowa City | Iowa | 52242 | Not yet recruiting |
| Local Institution - 0262 | Baltimore | Maryland | 21287 | Not yet recruiting |
| Maryland Oncology Hematology - Silver Spring | Silver Spring | Maryland | 20904 | Recruiting |
| Local Institution - 0471 | Boston | Massachusetts | 02114 | Withdrawn |
| Local Institution - 0430 | Ann Arbor | Michigan | 48109 | Not yet recruiting |
| Local Institution - 0254 | Grand Rapids | Michigan | 49546 | Not yet recruiting |
| Minnesota Oncology | Maple Grove | Minnesota | 55369 | Recruiting |
| Local Institution - 0318 | Kansas City | Missouri | 64111 | Not yet recruiting |
| Washington University School OF Medicine-Siteman Cancer Center | St Louis | Missouri | 63110 | Recruiting |
| Local Institution - 0334 | Omaha | Nebraska | 68198 | Not yet recruiting |
| Northwell Health/ RJ Zuckerberg Cancer Center | Lake Success | New York | 11042 | Recruiting |
| Local Institution - 0270 | Mineola | New York | 11501 | Not yet recruiting |
| Local Institution - 0273 | New Hyde Park | New York | 11042 | Not yet recruiting |
| Local Institution - 0290 | Charlotte | North Carolina | 28207 | Not yet recruiting |
| Local Institution - 0526 | Fargo | North Dakota | 58102 | Not yet recruiting |
| Local Institution - 0339 | Columbus | Ohio | 43210 | Not yet recruiting |
| Local Institution - 0605 | Oklahoma City | Oklahoma | 73104 | Not yet recruiting |
| Lehigh Valley Health Network | Allentown | Pennsylvania | 18103 | Recruiting |
| Local Institution - 0604 | Pittsburgh | Pennsylvania | 15232 | Not yet recruiting |
| Sanford Cancer Center | Sioux Falls | South Dakota | 57104 | Recruiting |
| Local Institution - 0333 | Nashville | Tennessee | 37203 | Not yet recruiting |
| SCRI Oncology Partners | Nashville | Tennessee | 37203 | Recruiting |
| Texas Oncology Dallas Fort Worth West (DFWW) - Arlington Cancer Center North | Arlington | Texas | 76012 | Recruiting |
| Texas Oncology, PA | Austin | Texas | 78705 | Recruiting |
| Local Institution - 0252 | Houston | Texas | 77030 | Not yet recruiting |
| Texas Oncology - San Antonio | San Antonio | Texas | 78240 | Recruiting |
| Local Institution - 0426 | Salt Lake City | Utah | 84102 | Not yet recruiting |
| Local Institution - 0278 | Fairfax | Virginia | 22031 | Not yet recruiting |
| Virginia Oncology Associates | Norfolk | Virginia | 23502 | Recruiting |
| Local Institution - 0491 | Edmonds | Washington | 98026-8032 | Not yet recruiting |
| Local Institution - 0253 | Seattle | Washington | 98109 | Not yet recruiting |
| Local Institution - 0629 | Spokane | Washington | 99218 | Not yet recruiting |
| Northwest Cancer Specialists, P.C. | Vancouver | Washington | 98684 | Recruiting |
Site contact phone numbers, emails, and investigator names are intentionally not displayed here. Open the official ClinicalTrials.gov record for site contact information.
Non-U.S. locations
This page focuses on the U.S. directory. The official record also lists 230 non-U.S. sites.
About this trial record page
- What this page shows
- Public field values for ClinicalTrials.gov record NCT07221357, including study identification, conditions, interventions, eligibility (age, sex, healthy volunteer), timeline, and U.S. site list.
- What this page does not do
- No medical advice, eligibility judgments, treatment recommendations, study quality scoring, or AI-generated medical summaries. No site contact phone numbers, emails, or investigator names.
- Where the data comes from
- Sourced from the official ClinicalTrials.gov public API. The official record is the source of truth.
- Last refresh
- Last update posted May 5, 2026 · Synced May 7, 2026
Related: full search, browse by condition, browse by drug or therapy, browse by sponsor, browse by U.S. city.
Open the official record
The complete protocol, eligibility criteria, and contact information for NCT07221357 live on ClinicalTrials.gov.